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The Journal of Heart and Lung Transplantation
International Society for Heart and Lung Transplantation.
Clinical dilemmas and innovation| Volume 28, ISSUE 9, P971-976, September 2009

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Clinical Experience Using the Levitronix CentriMag System for Temporary Right Ventricular Mechanical Circulatory Support

      Background

      Short-term mechanical circulatory support may be lifesaving in patients with right ventricular (RV) failure related to post-cardiotomy cardiogenic shock (PCCS), cardiac transplantation (CTx), and long-term therapy with a left ventricular assist device (LVAD). This study evaluates our clinical experience using the CentriMag (Levitronix LLC, Waltham, Mass) system for temporary mechanical RV support.

      Methods

      A retrospective review was performed of 29 patients (mean age, 57 ± 14 years) in whom the CentriMag system was used for RV support from September 2005 to March 2008.

      Results

      The indication for RV support was PCCS in 7 (24%), CTx in 10 (35%), and LVAD placement in 12 (41%). The mean support time was 8 ± 8 days. The device was successfully weaned in 3 PCCS patients (43%), 7 CTx patients (70%), and 7 LVAD patients (58%). Complications included major infection (pneumonia, sepsis, or LVAD pocket infection) in 13 (45%), arrhythmia in 13 (45%), reoperation for bleeding in 10 (35%), stroke/encephalopathy in 3 (10%), and air embolism in 1 (3%). Early mortality (< 30 days or before discharge) occurred in 14 patients (48%) of which 9 (31%) died with the device in place. Late death occurred in 2 of 15 patients (13%) who survived to discharge. There were no device failures.

      Conclusions

      The CentriMag system provides effective temporary mechanical circulatory support for RV failure. Ease of implantation and a high rate of successful device weaning justify the use of the CentriMag system for temporary RV support.
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      References

        • Moazami N.
        • Pasque M.K.
        • Moon M.R.
        • et al.
        Mechanical support for isolated right ventricular failure in patients after cardiotomy.
        J Heart Lung Transplant. 2004; 23: 1371-1375
        • Chen J.M.
        • Levin H.R.
        • Rose E.A.
        • et al.
        Experience with right ventricular assist devices for perioperative right-sided circulatory failure.
        Ann Thorac Surg. 1996; 61: 305-310
        • Dang N.C.
        • Topkara V.K.
        • Mercando M.
        • et al.
        Right heart failure after left ventricular assist device implantation in patients with chronic congestive heart failure.
        J Heart Lung Transplant. 2006; 25: 1-6
        • Kirklin J.K.
        • Naftel D.C.
        • Stevenson L.W.
        • et al.
        INTERMACS database for durable devices for circulatory support: first annual report.
        J Heart Lung Transplant. 2008; 27: 1065-1072
        • De Robertis F.
        • Birks E.J.
        • Rogers P.
        • Dreyfus G.
        • Pepper J.R.
        • Khaghani A.
        Clinical performance with the Levitronix CentriMag short-term ventricular assist device.
        J Heart Lung Transplant. 2006; 25: 181-186
        • Santise G.
        • Petrou M.
        • Pepper J.R.
        • Dreyfus G.
        • Khaghani A.
        • Birks E.J.
        Levitronix as a short-term salvage treatment for primary graft failure after heart transplantation.
        J Heart Lung Transplant. 2006; 25: 495-498
        • Whitson B.A.
        • D'Cunha J.
        • Knutsen A.C.
        • Boyle A.J.
        • Liao K.K.
        Levitronix ventricular assist device as a bridge to recovery after profound biventricular heart failure associated with pulmonary aspergillosis.
        J Heart Lung Transplant. 2007; 26: 345-349
        • John R.
        • Liao K.
        • Lietz K.
        • et al.
        Experience with the Levitronix CentriMag circulatory support system as a bridge to decision in patients with refractory acute cardiogenic shock and multisystem organ failure.
        J Thorac Cardiovasc Surg. 2007; 134: 351-358
        • Maat A.P.
        • van Thiel R.J.
        • Dalinghaus M.
        • Bogers A.J.
        Connecting the Centrimag Levitronix pump to berlin heart excor cannulae; a new approach to bridge to bridge.
        J Heart Lung Transplant. 2008; 27: 112-115
        • Shuhaiber J.H.
        • Jenkins D.
        • Berman M.
        • et al.
        The Papworth experience with the Levitronix CentriMag ventricular assist device.
        J Heart Lung Transplant. 2008; 27: 158-164
        • DeRobertis F.
        • Rogers P.
        • Amrani M.
        • et al.
        Bridge to decision using the Levitronix CentriMag short-term ventricular assist device.
        J Heart Lung Transplant. 2008; 27: 474-478
        • Clough R.E.
        • Vallely M.P.
        • Henein M.Y.
        • Pepper J.R.
        Levitronix ventricular assist device as a bridge-to-recovery for post-cardiotomy cardiogenic shock.
        Int J Cardiol. 2008; (doi:10.1016/j.ijcard.2008.02.002)
        • Gregoric I.D.
        • Cohn W.E.
        • Akay M.H.
        • LaFrancesca S.
        • Myers T.
        • Frazier O.H.
        CentriMag left ventricular assist system.
        Tex Heart Inst J. 2008; 35: 184-185
        • Farrar D.J.
        • Hill J.D.
        • Pennington D.G.
        • et al.
        Preoperative and postoperative comparison of patients with univentricular and biventricular support with the Thoratec ventricular assist device as a bridge to cardiac transplantation.
        J Thorac Cardiovasc Surg. 1997; 113: 202-209
        • Kormos R.L.
        • Gasior T.A.
        • Kawai A.
        • et al.
        Transplant candidate's clinical status rather than right ventricular function defines need for univentricular versus biventricular support.
        J Thorac Cardiovasc Surg. 1996; 111: 773-783
        • Noon G.P.
        • Lafuente J.A.
        • Irwin S.
        Acute and temporary ventricular support with BioMedicus centrifugal pump.
        Ann Thorac Surg. 1999; 68: 650-654
        • Jeevanandam V.
        • Furukawa S.
        • Prendergast T.W.
        • Todd B.A.
        • Eisen H.J.
        • McClurken J.B.
        Standard criteria for an acceptable donor heart are restricting heart transplantation.
        Ann Thorac Surg. 1996; 62: 1268-1275
        • Morgan J.A.
        • John R.
        • Lee B.J.
        • Oz M.C.
        • Naka Y.
        Is severe right ventricular failure in left ventricular assist device recipients a risk factor for unsuccessful bridging to transplant and post-transplant mortality.
        Ann Thorac Surg. 2004; 77: 859-863