The Journal of Heart and Lung Transplantation
International Society for Heart and Lung Transplantation.
Original Clinical Science BAS|Articles in Press

Controlled Donation after Circulatory Death Lung Transplantation: Results of the French Protocol Including In Situ Abdominal Normothermic Regional Perfusion and Ex Vivo Lung Perfusion.



      The French national protocol for controlled donation after circulatory determination of death (cDCD) includes normothermic regional perfusion (NRP) in case of abdominal organ procurement and additional ex-vivo lung perfusion (EVLP) before considering lung transplantation (LT).


      We made a retrospective study of a prospective registry that included all donors considered for cDCD LT from the beginning of the program in May 2016 to November 2021.


      One hundred grafts from 14 donor hospitals were accepted by 6 LT centers. The median duration of the agonal phase was 20 min [2-166]. The median duration from circulatory arrest to pulmonary flush was 62 min [20-90]. Ten lung grafts were not retrieved due to prolonged agonal phases (n=3), failure of NRP insertion (n=5), or poor in situ evaluation (n=2). The remaining 90 lung grafts were all evaluated on EVLP, with a conversion rate of 84% and a cDCD transplantation rate of 76%. The median total preservation time was 707 min [543-1038]. Seventy-one bilateral LTs and 5 single LTs were performed for chronic obstructive pulmonary disease (n= 29), pulmonary fibrosis (n=21), cystic fibrosis (n=15), pulmonary hypertension (n=8), graft-versus-host disease (n=2), and adenosquamous carcinoma (n=1). The rate of PGD3 was 9% [n=5]. The 1-year survival rate was 93.4%.


      After initial acceptance, cDCD lung grafts led to LT in 76% of cases, with outcomes similar to those already reported in the literature. The relative impacts of NRP and EVLP on the outcome following cDCD LT should be assessed prospectively in the context of comparative studies.



      controlled donation after circulatory determination of death (cDCD), normothermic regional perfusion (NRP), ex-vivo lung perfusion (EVLP), lung transplantation (LT), primary graft dysfunction (PGD), chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), cystic fibrosis (CF), pulmonary hypertension (PH), deceased brain deaths (DBDs), the International Society of Heart and Lung Transplantation (ISHLT), société Française de Chirurgie Thoracique et Cardio Vasculaire (SFCTCV), organ procurement organization (OPO), agence de la biomédecine (ABM), withdrawal of life-sustaining therapies (WLST), warm ischemic time (WIT), the inferior vena cava (IVC), the superior vena cava (SVC), extra corporeal membrane oxygenation (ECMO), cardio pulmonary bypass (CPB)
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