By unloading the failing heart, left ventricular (LV) assist devices (LVADs) provide a favorable environment for reversing adverse structural and functional cardiac changes. Prior reports have suggested that an improved native LV function might contribute to the development of LVAD thrombosis. We used the Interagency Registry for Mechanically Assisted Circulatory Support and found that LV functional improvement is associated with a lower risk for device thrombosis. The risk for cerebrovascular accident and transient ischemic attack was comparable across post-LVAD LV function subgroups, while the risk of hemolysis was lower in subgroups of patients with better LV function on LVAD support.
Abbreviations:CVA (Cerebrovascular accident), HF (Heart failure), HR (Hazard ratio), Intermacs (Interagency Registry for Mechanically Assisted Circulatory Support), LV (Left ventricle/left ventricular), LVAD (Left ventricular assist device), LVEF (Left ventricular ejection fraction), TIA (Transient ischemic attack)
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