Thoracoabdominal normothermic regional perfusion (TA-NRP) has recently begun being
utilized in the United States for recovery of cardiothoracic allografts from some
donors after circulatory death (DCD), but data on lungs recovered in this method is
limited to case reports. We conducted a national retrospective review of lung transplants
from DCD donors recovered using TA-NRP. Of the 434 total DCD lung transplants performed
between January 2020 and March 2022, 17 were recovered using TA-NRP. Compared to direct
recovery DCD transplants, recipients of TA-NRP DCD transplants had lower likelihood
of ventilation >48 hours (23.5% vs 51.3%, p = 0.027) and similar likelihood of predischarge acute rejection, requirement for
extracorporeal membrane oxygenation at 72 hours, hospital lengths of stay, and survival
at 30, 60, and 90 days post-transplant. These early data suggest that DCD lung recovery
using TA-NRP might be a safe way to further expand the donor pool and warrant further
study.
KEYWORDS
Abbreviations:
DCD (donation after circulatory death), ECMO (extracorporeal membrane oxygenation), EVLP (ex vivo lung perfusion), NRP (normothermic regional perfusion), TA-NRP (thoracoabdominal normothermic regional perfusion), UNOS (United Network for Organ Sharing)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: March 07, 2023
Publication stage
In Press Journal Pre-ProofIdentification
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© 2023 International Society for Heart and Lung Transplantation. All rights reserved.
