ABSTRACT
Thoracoabdominal normothermic regional perfusion (TA-NRP) has recently begun being
utilized in the United States for recovery of cardiothoracic allografts from some
donors after circulatory death (DCD), but data on lungs recovered in this method is
limited to case reports. We conducted a national retrospective review of lung transplants
from DCD donors recovered using TA-NRP. Of the 434 total DCD lung transplants performed
between January 2020 and March 2022, 17 were recovered using TA-NRP. Compared to direct
recovery DCD transplants, recipients of TA-NRP DCD transplants had lower likelihood
of ventilation >48 hours (23.5% vs. 51.3%, p=0.027) and similar likelihood of pre-discharge
acute rejection, requirement for extracorporeal membrane oxygenation at 72 hours,
hospital lengths of stay, and survival at 30, 60, and 90 days post-transplant. These
early data suggest that DCD lung recovery using TA-NRP might be a safe way to further
expand the donor pool and warrant further study.
Keywords
Abbreviations:
DCD (donation after circulatory death), ECMO (extracorporeal membrane oxygenation), EVLP (ex vivo lung perfusion), NRP (normothermic regional perfusion), TA-NRP (thoracoabdominal normothermic regional perfusion), UNOS (United Network for Organ Sharing)To read this article in full you will need to make a payment
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