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The Journal of Heart and Lung Transplantation
International Society for Heart and Lung Transplantation.

Natural killer cells, CMV infection, and antibody-mediated rejection

Published:December 26, 2022DOI:https://doi.org/10.1016/j.healun.2022.12.017
      Antibody-mediated rejection (ABMR) results from a pro-inflammatory cascade that occurs following the binding of circulating anti-HLA antibodies to HLA on donor endothelial cells. As such, pathogenic pathways of humoral immunity are considered key targets for diagnostic and therapeutic focus. As one example, antibody-dependent cell-mediated cytotoxicity (ADCC) is an important mechanism of ABMR, in which graft-bound anti-HLA antibodies activate innate leukocytes such as natural killer (NK) cells and monocytes via surface Fc gamma receptors for IgG
      • Akiyoshi T
      • Hirohashi T
      • Alessandrini A
      • et al.
      Role of complement and NK cells in antibody mediated rejection.
      .
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      References

        • Akiyoshi T
        • Hirohashi T
        • Alessandrini A
        • et al.
        Role of complement and NK cells in antibody mediated rejection.
        Human Immunology. 2012; 73: 1226-1232
        • Calabrese DR
        • Lanier LL
        • Greenland JR.
        Natural killer cells in lung transplantation.
        Thorax. 2019; 74: 397-404
        • Kiessling R
        • Klein E
        • Pross H
        • Wigzell H.
        Natural" killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer cell.
        Eur J Immunol. 1975; 5: 117-121
        • Renard V
        • Cambiaggi A
        • Vély F
        • et al.
        Transduction of cytotoxic signals in natural killer cells: a general model of fine tuning between activatory and inhibitory pathways in lymphocytes.
        Immunol Rev. 1997; 155: 205-221
        • Maroof A
        • Beattie L
        • Zubairi S
        • Svensson M
        • Stager S
        • Kaye PM.
        Posttranscriptional regulation of II10 gene expression allows natural killer cells to express immunoregulatory function.
        Immunity. 2008; 29: 295-305
        • Greenland JR
        • Sun H
        • Calabrese D
        • et al.
        HLA Mismatching Favoring Host-Versus-Graft NK Cell Activity Via KIR3DL1 Is Associated With Improved Outcomes Following Lung Transplantation.
        Am J Transplant. 2017; 17: 2192-2199
        • Benichou G
        • Yamada Y
        • Aoyama A
        • Madsen JC.
        Natural killer cells in rejection and tolerance of solid organ allografts.
        Curr Opin Organ Transplant. 2011; 16: 47-53
        • Barnes S
        • Schilizzi O
        • Audsley KM
        • Newnes HV
        • Foley B.
        Deciphering the Immunological Phenomenon of Adaptive Natural Killer (NK) Cells and Cytomegalovirus (CMV).
        International Journal of Molecular Sciences. 2020; 21: 8864
      1. Vietzen H, Jaksch P, Puchhammer-Stöckl E. The Human Cytomegalovirus-Specific and UL40-Mediated Imprint in the Natural Killer Cell Repertoire is Associated with Antibody-Mediated Rejection in Lung Transplant Recipients. The Journal of Heart and Lung Transplantation.

        • Bayard C
        • Lepetitcorps H
        • Roux A
        • et al.
        Coordinated expansion of both memory T cells and NK cells in response to CMV infection in humans.
        Eur J Immunol. 2016; 46: 1168-1179
        • Yazdani S
        • Callemeyn J
        • Gazut S
        • et al.
        Natural killer cell infiltration is discriminative for antibody-mediated rejection and predicts outcome after kidney transplantation.
        Kidney Int. 2019; 95: 188-198
        • Lin CM
        • Gill RG
        • Mehrad B.
        The natural killer cell activating receptor, NKG2D, is critical to antibody-dependent chronic rejection in heart transplantation.
        Am J Transplant. 2021; 21: 3550-3560
        • Levine DJ
        • Glanville AR
        • Aboyoun C
        • et al.
        Antibody-mediated rejection of the lung: A consensus report of the International Society for Heart and Lung Transplantation.
        J Heart Lung Transplant. 2016; 35: 397-406
        • Wallace WD
        • Li N
        • Andersen CB
        • et al.
        Banff study of pathologic changes in lung allograft biopsy specimens with donor-specific antibodies.
        J Heart Lung Transplant. 2016; 35: 40-48
        • Roden AC
        • Maleszewski JJ
        • Yi ES
        • et al.
        Reproducibility of Complement 4d deposition by immunofluorescence and immunohistochemistry in lung allograft biopsies.
        J Heart Lung Transplant. 2014; 33: 1223-1232
        • Sis B
        • Halloran PF.
        Endothelial transcripts uncover a previously unknown phenotype: C4d-negative antibody-mediated rejection.
        Curr Opin Organ Transplant. 2010; 15: 42-48
        • Halloran KM
        • Parkes MD
        • Chang J
        • et al.
        Molecular assessment of rejection and injury in lung transplant biopsies.
        J Heart Lung Transplant. 2019; 38: 504-513