The Journal of Heart and Lung Transplantation
International Society for Heart and Lung Transplantation.

Natural killer cells, CMV infection, and antibody-mediated rejection

Published:December 26, 2022DOI:
      Antibody-mediated rejection (ABMR) results from a pro-inflammatory cascade that occurs following the binding of circulating anti-HLA antibodies to HLA on donor endothelial cells. As such, pathogenic pathways of humoral immunity are considered key targets for diagnostic and therapeutic focus. As one example, antibody-dependent cell-mediated cytotoxicity (ADCC) is an important mechanism of ABMR, in which graft-bound anti-HLA antibodies activate innate leukocytes such as natural killer (NK) cells and monocytes via surface Fc gamma receptors for IgG
      • Akiyoshi T
      • Hirohashi T
      • Alessandrini A
      • et al.
      Role of complement and NK cells in antibody mediated rejection.
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