Abstract
Equipoise remains about how best to measure cardiac output (CO) in patients with left
ventricular assist devices (LVAD). In this study, direct Fick CO was compared with
thermodilution (TD) and indirect Fick (iFick) CO in 61 LVAD patients. TD and LaFarge
iFick showed moderate correlation with direct Fick (R2=0.49 and R2=0.38, p<0.001 for both), while Dehmer and Bergstra iFick showed poor correlation
with direct Fick (R2=0.29 and R2=0.31, p<0.001 for both). Absolute bias between all CO estimation techniques and direct
Fick CO was lowest for TD compared to iFick methods but significant for all methods.
All methods tended to overestimate CO compared to direct Fick, with greatest overestimation
present in those with the lowest measured direct Fick CO. Bias and frequency of significant
discrepancy were least using TD and Lafarge iFick CO estimation methods in this study,
with TD CO demonstrating modestly better correlation and less heteroscedasticity compared
to Lafarge.
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References
- Impact of Hemodynamic Ramp Test-Guided HVAD Speed and Medication Adjustments on Clinical Outcomes.Circ Heart Fail. 2019 Apr; 12e006067
- The development of aortic insufficiency in left ventricular assist device-supported patients.Circ Heart Fail. 2010; 3: 668
- Left ventricular assist devices: a rapidly evolving alternative to transplant.J Am Coll Cardiol. 2015; 65: 2542-2555
- Prevalence of de novo aortic insufficiency during long-term support with left ventricular assist devices.J Heart Lung Transplant. 2010; 29: 1172
- Left Ventricular Decompression During Speed Optimization Ramps in Patients Supported by Continuous-Flow Left Ventricular Assist Devices: Device-Specific Performance Characteristics and Impact on Diagnostic Algorithms.J Card Fail. 2015 Oct; 21: 785-791
- Thermodilution vs Estimated Fick Cardiac Output Measurement in Clinical Practice: An Analysis of Mortality From the Veterans Affairs Clinical Assessment, Reporting, and Tracking (VA CART) Program and Vanderbilt University.JAMA Cardiol. 2017; 2: 1090-1099https://doi.org/10.1001/jamacardio.2017.2945
- Comparison of Accuracy of Estimation of Cardiac Output by Thermodilution Versus the Fick Method Using Measured Oxygen Uptake.Am J Cardiol. 2022 Aug 1; 176 (Epub 2022 May 22. PMID: 35613956): 58-65https://doi.org/10.1016/j.amjcard.2022.04.026
- Optimal haemodynamics during left ventricular assist device support are associated with reduced haemocompatibility-related adverse events.Eur J Heart Fail. 2019 May; 21: 655-662
- Comparison of Estimations Versus Measured Oxygen Consumption at Rest in Patients With Heart Failure and Reduced Ejection Fraction Who Underwent Right-Sided Heart Catheterization.The American Journal of Cardiology. 2015; 116: 1724-1730
- A formula to estimate the approximate surface area if height and weight be known.Arch Intern Med. 1916; 17: 863-871
- Comprehensive Diagnostic Evaluation of Cardiovascular Physiology in Patients With Pulmonary Vascular Disease: Insights From the PVDOMICS Program.Circ Heart Fail. 2020 Mar; 13e006363
- Understanding Bland Altman analysis.Biochemia medica. 2015; 25: 141-151
- Resting Oxygen Consumption and Heart Failure: Importance of Measurement for Determination of Cardiac Output With the Use of the Fick Principle.J Card Fail. 2020 Aug; 26 (Epub 2019 Feb 10): 664-672https://doi.org/10.1016/j.cardfail.2019.02.004
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© Published by Elsevier Inc. on behalf of International Society for Heart and Lung Transplantation.
