Equipoise remains about how best to measure cardiac output (CO) in patients with left
ventricular assist devices (LVAD). In this study, direct Fick CO was compared with
thermodilution (TD) and indirect Fick (iFick) CO in 61 LVAD patients. TD and LaFarge
iFick showed moderate correlation with direct Fick (R2 = 0.49 and R2 = 0.38, p < 0.001 for both), while Dehmer and Bergstra iFick showed poor correlation with direct
Fick (R2 = 0.29 and R2 = 0.31, p < 0.001 for both). Absolute bias between all CO estimation techniques and direct
Fick CO was lowest for TD compared to iFick methods but significant for all methods.
All methods tended to overestimate CO compared to direct Fick, with greatest overestimation
present in those with the lowest measured direct Fick CO. Bias and frequency of significant
discrepancy were least using TD and Lafarge iFick CO estimation methods in this study,
with TD CO demonstrating modestly better correlation and less heteroscedasticity compared
to Lafarge.
KEYWORDS
Abbreviations:
BSA (Body surface area), CO (Cardiac outputi), Fick (Indirect Fick), LVAD (Left ventricular assist device), RHC (Right heart catheterization), TD (Thermodilution), VO2 (Oxygen consumption)To read this article in full you will need to make a payment
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Publication history
Published online: November 17, 2022
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