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The Journal of Heart and Lung Transplantation
International Society for Heart and Lung Transplantation.

Lung transplantation following donation after thoraco-abdominal normothermic regional perfusion (TA-NRP): A feasibility case study

  • Author Footnotes
    † These first authors contributed equally to this work.
    Caroline Boelhouwer
    Footnotes
    † These first authors contributed equally to this work.
    Affiliations
    Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium
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  • Author Footnotes
    † These first authors contributed equally to this work.
    Katrien Vandendriessche
    Footnotes
    † These first authors contributed equally to this work.
    Affiliations
    Department of Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium

    Department of Cardiovascular Sciences, division of Cardiac Surgery, KU Leuven, Leuven, Belgium
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  • Dirk Van Raemdonck
    Affiliations
    Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium

    Department of Chronic Diseases and Metabolism, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium
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  • Ina Jochmans
    Affiliations
    Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium

    Department of Abdominal Transplant Surgery and Coordination, University Hospitals Leuven, Leuven, Belgium
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  • Diethard Monbaliu
    Affiliations
    Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium

    Department of Abdominal Transplant Surgery and Coordination, University Hospitals Leuven, Leuven, Belgium
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  • Karlien Degezelle
    Affiliations
    Department of Intensive Care Medicine, University Hospitals Leuven, Leuven, Belgium
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  • Jan Gunst
    Affiliations
    Department of Cardiac Surgery, division perfusion, University Hospitals Leuven, Leuven, Belgium

    Department of Cellular and Molecular Medicine, Laboratory of Intensive Care Medicine, KU Leuven, Leuven, Belgium
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  • Christophe Vandenbriele
    Affiliations
    Department of Cardiovascular Sciences, University Hospitals Leuven, Leuven, Belgium

    Department of Cardiovascular Sciences, division of Cardiology, KU Leuven, Leuven, Belgium
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  • Dieter Van Beersel
    Affiliations
    Department of Anesthesiology, University Hospitals Leuven, Leuven, Belgium

    Department of Cardiovascular Sciences, division of Anesthesiology and Algology, KU Leuven, Leuven, Belgium
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  • Robin Vos
    Affiliations
    Department of Chronic Diseases and Metabolism, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium

    Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium
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  • Geert M. Verleden
    Affiliations
    Department of Chronic Diseases and Metabolism, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium

    Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium
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  • Filip Rega
    Affiliations
    Department of Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium

    Department of Cardiovascular Sciences, division of Cardiac Surgery, KU Leuven, Leuven, Belgium
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  • Author Footnotes
    ‡ These senior authors contributed equally to this work.
    Arne P. Neyrinck
    Footnotes
    ‡ These senior authors contributed equally to this work.
    Affiliations
    Department of Anesthesiology, University Hospitals Leuven, Leuven, Belgium

    Department of Cardiovascular Sciences, division of Anesthesiology and Algology, KU Leuven, Leuven, Belgium
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  • Author Footnotes
    ‡ These senior authors contributed equally to this work.
    ,
    Author Footnotes
    1 LinkedIn: www.linkedin.com/in/laurens-ceulemans-1190a7a1.
    Laurens J. Ceulemans
    Correspondence
    Reprint requests: Laurens J. Ceulemans, MD, PhD, Department of Thoracic Surgery and Lung Transplantation, University Hospitals Leuven/KU Leuven, Herestraat 49, 3000 Leuven, Belgium. Telephone: 0032 16 34 68 20. Fax: 0032 16 34 68 21.
    Footnotes
    ‡ These senior authors contributed equally to this work.
    1 LinkedIn: www.linkedin.com/in/laurens-ceulemans-1190a7a1.
    Affiliations
    Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium

    Department of Chronic Diseases and Metabolism, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium
    Search for articles by this author
  • with support of the Leuven Donor Working Group
  • Author Footnotes
    † These first authors contributed equally to this work.
    ‡ These senior authors contributed equally to this work.
    1 LinkedIn: www.linkedin.com/in/laurens-ceulemans-1190a7a1.
Published:September 20, 2022DOI:https://doi.org/10.1016/j.healun.2022.09.011
      Donation after circulatory death (DCD) has expanded the donor pool for lung transplantation (LTx).
      • Ceulemans LJ
      • Inci I
      • Van Raemdonck D
      Lung donation after circulatory death.
      With the successful emergence of thoraco-abdominal normothermic regional perfusion (TA-NRP) to increase cardiac DCD, the effect on LTx remains unknown.
      • Messer S
      • Cernic S
      • Page A
      • et al.
      A 5-year single-center early experience of heart transplantation from donation after circulatory-determined death donors.
      ,
      • Jochmans I
      • Hessheimer AJ
      • Neyrinck AP
      • et al.
      Consensus statement on normothermic regional perfusion in donation after circulatory death: report from the European Society for Organ Transplantation's Transplant Learning Journey.
      We report the technique and short-term outcome of two LTx following TA-NRP and cold storage. Reporting was granted by the Institutional Ethics Board (MP016722/S51577).

      Keywords

      Abbreviations:

      A-NRP (abdominal normothermic regional perfusion), CMV (cytomegalovirus), DBD (donation after brain death), DCD (donation after circulatory death), ECLS (extra-corporeal life support), FiO2 (Fraction of inspired oxygen), ICU (intensive care unit), LTx (lung transplantation), NRP (normothermic regional perfusion), PEEP (positive end-expiratory pressure), PGD (primary graft dysfunction), RR (rapid recovery), SBP (systolic blood pressure), TA-NRP (thoraco-abdominal normothermic regional perfusion), TEE (transesophageal echocardiography), TWIT (total warm ischemia time), WLST (withdrawal from life-sustaining therapy)
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