Advertisement
The Journal of Heart and Lung Transplantation
International Society for Heart and Lung Transplantation.

Initial bridge to transplant experience with a bioprosthetic autoregulated artificial heart

      The Carmat total artificial heart (C-TAH) is an electro-hydraulically‒actuated heart replacement device with biocompatible blood-contacting materials and sensor-based autoregulation. It intends to replace the native heart in patients suffering from end-stage biventricular heart failure. The device provides fully pulsatile blood flow, adapted to the patient's activities by autoregulation.
      • Bizouarn P
      • Roussel JC
      • Trochu JN
      • Perlès JC
      • Latrémouille C
      Effects of pre-load variations on hemodynamic parameters with a pulsatile autoregulated artificial heart during the early post-operative period.
      This report summarizes the initial experience with clinical heart transplants from C-TAH implantation within an ongoing European Multicenter Pivotal Study with the primary end-point of 180-day post-implant survival or survival to cardiac transplantation (ClinicalTrials.gov Identifier: NCT02962973). The study was approved by relevant Ethics Committees and Regulatory Authorities. All patients signed informed consent to participate in the trial.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to The Journal of Heart and Lung Transplantation
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Bizouarn P
        • Roussel JC
        • Trochu JN
        • Perlès JC
        • Latrémouille C
        Effects of pre-load variations on hemodynamic parameters with a pulsatile autoregulated artificial heart during the early post-operative period.
        J Heart Lung Transplant. 2018; 37: 161-163
        • Carpentier A
        • Latrémouille C
        • Cholley B
        • et al.
        First clinical use of a bioprosthetic total artificial heart: report of two cases.
        Lancet. 2015; 386: 1556-1563
        • Kang G
        • Ha R
        • Banerjee D
        Pulmonary artery pulsatility index predicts right ventricular failure after left ventricular assist device implantation [published correction appears in J Heart Lung Transplant 2017;36:1272].
        J Heart Lung Transplant. 2016; 35: 67-73
        • Lavee J
        • Mulzer J
        • Krabatsch T
        • et al.
        An international multicenter experience of biventricular support with HeartMate 3 ventricular assist systems.
        J Heart Lung Transplant. 2018; 37: 1399-1402
        • Shah P
        • Ha R
        • Singh R
        • et al.
        Multicenter experience with durable biventricular assist devices.
        J Heart Lung Transplant. 2018; 37: 1093-1101