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The Journal of Heart and Lung Transplantation
International Society for Heart and Lung Transplantation.

First-in-man use of the MVAD axial-flow pump: Long-term outcome

      The use of durable continuous-flow mechanical assist devices provides selected heart failure patients with both symptomatic and functional benefits; however, they are not without potential complications. Infection, thrombosis, stroke, and gastrointesinal bleeding are among the most commonly reported problems of left ventricular assist device (LVAD) therapy.
      • Kirklin J.K.
      • Naftel D.C.
      • Pagani F.D.
      • et al.
      Seventh INTERMACS annual report: 15,000 patients and counting.
      • Stulak J.M.
      • Davis M.E.
      • Haglund N.
      • et al.
      Adverse events in contemporary continuous-flow left ventricular assist devices: a multi-institutional comparison shows significant differences.
      • Estep J.D.
      • Starling R.C.
      • Horstmanshof D.A.
      • et al.
      Risk assessment and comparative effectiveness of left ventricular assist device and medical management in ambulatory heart failure patients: results from the ROADMAP study.
      In addition, LVAD peripherals can be bulky and heavy for the patient to carry, causing joint stress, discomfort, and reduced quality of life. Device miniaturization is one design trend that has enabled device implantation in patients with a broader range of body sizes, and, when used with minimally invasive approaches, has reduced surgical trauma and complications such as bleeding and infection.
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      References

        • Kirklin J.K.
        • Naftel D.C.
        • Pagani F.D.
        • et al.
        Seventh INTERMACS annual report: 15,000 patients and counting.
        J Heart Lung Transplant. 2015; 34: 1495-1504
        • Stulak J.M.
        • Davis M.E.
        • Haglund N.
        • et al.
        Adverse events in contemporary continuous-flow left ventricular assist devices: a multi-institutional comparison shows significant differences.
        J Thorac Cardiovasc Surg. 2016; 151: 177-189
        • Estep J.D.
        • Starling R.C.
        • Horstmanshof D.A.
        • et al.
        Risk assessment and comparative effectiveness of left ventricular assist device and medical management in ambulatory heart failure patients: results from the ROADMAP study.
        J Am Coll Cardiol. 2015; 66: 1747-1761
        • McGee Jr, E.
        • Chorpenning K.
        • Brown M.C.
        • et al.
        In vivo evaluation of the HeartWare MVAD pump.
        J Heart Lung Transplant. 2014; 33: 366-371
        • Cheung A.
        • Chorpenning K.
        • Tamez D.
        • et al.
        Design concepts and preclinical results of a miniaturized HeartWare platform: the MVAD system.
        Innovations. 2015; 11: 151-156