The Journal of Heart and Lung Transplantation
International Society for Heart and Lung Transplantation.

Changes in Metabolic Substrate Utilization and Pyruvate Mitochondrial Oxidation Mismatch during Mechanical Unloading of the Failing Human Heart: Implications for Cardiac Reloading and Conditioning

      Mechanical unloading induced by left ventricular assist devices (LVAD) reverses several but not all aspects of myocardial remodeling and usually leads to incomplete cardiac recovery in a subset of advanced heart failure (HF) patients. We sought to investigate the effects of mechanical unloading on myocardial energetics and the metabolic perturbation of HF in an effort to identify new therapeutic targets that could enhance the unloading- induced cardiac recovery.
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