Background
Pandemic 2009 H1N1 influenza virus (H1N1) infection is considered harmful to lung
transplant recipients (LTRs). Vaccination against this virus is recommended for LTRs,
but little is known about associated benefits and risks. Our aim in this study is
to document the safety and clinical effectiveness of the H1N1 vaccine in LTRs.
Methods
All LTRs received an informational letter on the H1N1 pandemic that included hygiene
and vaccination recommendations. After completing a questionnaire, volunteering LTRs
received Pandemrix (H1N1 2009 Monovalent AS03-Adjuvanted Vaccine; GSK). Adverse events
(AEs) were documented at short-term follow-up visits and by telephone. Any flu-like
symptoms were reported and a low threshold for performing nasal/pharyngeal swabs for
virus detection was maintained.
Results
Of 168 eligible LTRs (107 already vaccinated for 2009 seasonal influenza), 148 (88%)
received at least one vaccination with the H1N1 vaccine and 115 received a second
dose. After the first vaccination, 44% had no AEs. Six self-limiting, severe AEs occurred,
and the remainder were minor to moderate, predominantly injection-site reactions.
After the second vaccination, AEs were clearly less frequent. All AEs resolved completely.
Documented H1N1 infection occurred in 2 of 148 vaccinated LTRs, in contrast to 5 infections
in 20 non-vaccinated LTRs.
Conclusions
H1N1 vaccination is generally well tolerated with mild to moderate, predominantly
local AEs in most LTRs and few self-limiting severe events. Clinical effectiveness
is good.
Keywords
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Article info
Publication history
Published online: March 28, 2011
Identification
Copyright
© 2011 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.
