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The Journal of Heart and Lung Transplantation
International Society for Heart and Lung Transplantation.

Scientific Registry of the International Society for Heart and Lung Transplantation: Introduction to the 2005 Annual Reports

      We are pleased to present the 2005 annual reports of the Scientific Registry of the International Society for Heart and Lung Transplantation (the Registry). The Registry remains the world’s most comprehensive record of heart and lung transplant activity, practices and outcomes. At present, the Registry contains data on 70,201 heart transplants, 3,154 heart-lung transplants and 19,296 lung transplants. During the past year, more than 4,500 transplants reported from over 200 centers were added to the Registry. The Mechanical Circulatory Support Device (MCSD) database now includes data on 831 implantations reported from 60 centers worldwide. We extend our continued gratitude to the many cardiothoracic surgeons, physicians, data coordinators and organ-exchange organizations throughout the world, whose timely and accurate submission of data has made these analyses possible.

      New data analysis types

      In addition to our usual analyses, there are several new features in this year’s Registry reports. First, we have expanded the analyses of the use of newer immunosuppressive drugs and drug combinations. In addition, we have included analyses of the influence of induction and maintenance immunosuppressive drugs and combinations on the incidence of acute rejection and survival after transplantation. Finally, we have constructed hypothetical clinical scenarios that graphically illustrate the influence of various clinical parameters on heart and lung transplant outcomes.

      Simplified reporting of “Tier 1” data

      As promised in the Introduction to last year’s Registry reports, we have now implemented a simplified, online “Tier 1” data entry process, which requires only 14 data elements to register a patient, and only 3 data elements to complete the annual update for a patient. A new transplant case can be registered in as little as 2 minutes! By providing this less labor-intensive pathway for data reporting, we hope to improve the Registry’s ability to reflect the total number of transplants performed worldwide. Of course, all transplant centers wishing to submit all of the data currently collected by the Registry (now referred to as “Tier 2” data) will continue to be able to do so. Tier II data expand the patient profile to include pre-transplant, transplant and discharge information on the recipient as well as data on the organ donor.

      Access to Registry data

      There are many ways to access the Registry data (Table 1). As in past years, all data figures and tables included in the Registry reports are also available for viewing and downloading on the ISHLT website (www.ishlt.org/registries) in Microsoft PowerPoint format. The website also contains many additional data slides that are not included in the published reports. In addition, those wishing to view the published Heart, Lung and Heart-Lung, Pediatric and MCSD reports online may do so by contacting www.jhltonline.org.
      Table 1Methods for On-line Access of ISHLT Registry Data
      1. Registry slide set
       • Available to all in Microsoft PowerPoint format (www.ishlt.org/registries)
      2. Registry manucripts
       • Available at www.jhltonline.org
      3. Online continent-specific reports
       • Available to all at ISHLT website (www.ishlt.org)
      4. Online center-specific reports
       • Available at secure section of ISHLT website (www.ishlt.org)
       • Available to all actively participating centers
       • Requires user name and password: contact Kathryn Philibin ( [email protected] ) for information
      In addition to the information available in the published Registry reports and slide sets, continent- and center-specific data reports can be obtained from the secure section of the ISHLT website (www.ishlt.org). These include: transplant counts; tabulations of recipient, transplant and donor demographics; and survival rates stratified by demographic parameters. Continent-specific reports are available to everyone and allow comparison of continent-specific transplant and outcome data with those of all transplants submitted to the Registry. Center-specific reports allow comparison of one’s own individual center with that of all transplants submitted to the Registry. These reports are available to all actively participating centers, including those submitting data via organ-exchange organizations. Because we only want staff members affiliated with each center to access center-specific reports from their own center, center-specific reports require a user name and password, which can be obtained from Kathryn Philibin ( [email protected] ).

      Requests for additional data and data analyses

      ISHLT members and non-members frequently request Registry data that are not readily available in the slide set or in the continent- or center-specific reports. To facilitate and expedite these data queries, we have developed a uniform process by which they are handled. All requests are first submitted to the ISHLT headquarters office, accompanied by a data request form (available at www.ishlt.org). ISHLT staff will determine the number of hours each request will require, allowing each request to be assigned to a specific level (Table 2). For approved data requests, ISHLT members may be granted a specific number of hours of data analysis and biostatistical support for publication of new information regarding heart and lung transplantation.
      Table 2Summary of the 3 levels of Registry Data Request
      Analysis time requiredUsual turnaround timeRequirements
      Level 1: Simple inquiries/clarification<1 hour<14 daysAvailable to all
      Level 2: New analyses of existing data<5 hours4 to 6 weeksISHLT members only
      Level 3: Complex analyses of existing data/new data collection>5 hoursVariableISHLT members only; reviewed by Executive Committee (Feb., June, Oct.)

      APPENDIX.

      Tabled 1
      CountryCenterTransplants performed in 2002 and reported to ISHLTTransplants performed 1/2003 to 6/2004 and reported to ISHLT
      ArgentinaFundacion Favaloroxx
      Australia
      Data provided via Australia and New Zealand Cardiothoracic Transplant Registry (ANZCTR).
      St Vincentxx
      Prince Charles Hospitalxx
      Royal Children’s Hospitalxx
      Alfred Hospitalxx
      Royal Perth Hospitalxx
      Austria
      Data provided via Eurotransplant.
      Universitätsklinik für Chirurgie, Wienxx
      Universitätsklinik für Chirurgie, Innsbruckxx
      Universitätsklinik für Chirurgie, Grazxx
      Belgium
      Data provided via Eurotransplant.
      Hôpital Erasme, Bruxellesxx
      Universitair Ziekenhuis Gasthuisberg, Leuvenxx
      Universitair Ziekenhuis Antwerpen, Edegemxx
      Onze Lieve Vrouw Ziekenhuis, Aalstxx
      Universitair Ziekenhuis, Gentxx
      Université Catholique de Louvain, Cliniques Universitaires St Luc, Bruxellesxx
      Centre Hospitalier Universitaire, Liègexx
      CanadaRoyal Victoria Hospitalxx
      Montreal Heart Institutexx
      Toronto General Hospitalxx
      Hospital Notre-Damexx
      Quebec Heart Institute-Laval Hospitalxx
      Ottawa Heart Institutex
      University of Alberta Hospitals/Walter C. Mackenzie Health Sciencesxx
      St Paul’s Hospitalxx
      Vancouver General Hospitalxx
      Hospital for Sick Childrenxx
      ChileHospital DIPRECAx
      Clinica Las Condesxx
      Denmark
      Data provided via Scandiatransplant.
      Skejby University Hospitalxx
      Rigshospitalet, National University Hospitalxx
      Finland
      Data provided via Scandiatransplant.
      Helsinki University Central Hospitalxx
      Children’s Hospital, University of Helsinkixx
      FranceHopital Cardiolgique (Lille)x
      Hopices Civils Hopital Universitaires de Strasbourgx
      Germany
      Data provided via Eurotransplant.
      Universitätsklinikum des Saarlandes, Homburg-Saarx
      Herzzentrum Dresden gmbh, Universitätsklinikumxx
      Deutsches Herzzentrum Berlinxx
      Universitäts-Krankenhaus Eppendorf, Klinik für Herz-und Gefässchirurgie, Hamburgxx
      Universitätsklinikum Kölnxx
      Universitätsklinikum Leipzig, Klinik für Abdominal-, Transplantations-und Gefässchirurgie, Leipzigxx
      Klinikum der Universität, Regensburgxx
      Herz- & Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausenxx
      Universitätsklinikum Freiburgxx
      Universitätsklinikum Essen, Klinik für Thorax- und Kardiovaskuläre Chirurgiexx
      Klinikum der Johannes-Gutenberg-Universität, Mainzxx
      Heinrich-Heine Universität Düsseldorfx
      Westfälischen Wilhelms-Universität, Münsterxx
      Klinikum Grosshadern der Ludwig-Maximilians Universität, Münchenxx
      Klinikum der Ruprecht-Karls-Universität, Chirurgischen Universitätsklinik, Abteilung für Herzchirurgie, Heidelbergxx
      Medizinischen Hochschule, Hannoverxx
      Klinikum der Georg-August-Universität, Göttingenxx
      Universitätsklinikum der Rheinisch-xx
      Westfälischen TH, Aachen
      Klinikum Fulda, Thorax-, Herz- und Gefässchirurgiexx
      Universitätsklinikum der Johann Wolfgang Goethe-Universität, Thorax- Herz- und Thorakale Gefässchirurgie, Frankfurt am Mainxx
      Klinikum der Justus-Liebig Universität, Gieβenxx
      Universitätsklinikum Kiel, Klinik für Herz- und Gefässchirurgiexx
      Klinikum der Friedrich-Schiller-Universität, Jenaxx
      Universitätsklinikum Erlangenxx
      Deutsches Herzzentrum Münchenxx
      GreeceOnassis Cardiac Surgery Centerxx
      Ireland
      Data provided via UK Transplant.
      Mater Hospitalxx
      IsraelSheba Medical Centerxx
      ItalyPoliclinico S. Orsola-Universita degli Studixx
      Ospedali Riunitix
      Universita Paviaxx
      Niguarda CA Granda Hospital
      JapanTohoku University, IDAC Hospitalx
      Osaka University Hospitalx
      National Cardiovascular Centerxx
      The Netherlands
      Data provided via Eurotransplant.
      Universitair Medisch Centrum Utrechtxx
      Erasmus MC, Universitair Medisch Centrum, Rotterdamxx
      Groningen Universitair Medisch Centrumxx
      New Zealand
      Data provided via Australia and New Zealand Cardiothoracic Transplant Registry (ANZCTR).
      Green Lane Hospitalxx
      Norway
      Data provided via Scandiatransplant.
      Rikshospitalet-National Hospital of Norwayxx
      Slovenia
      Data provided via Eurotransplant.
      University Medical Center, Ljubljanaxx
      SpainHospital Clinic-Barcelonaxx
      Hospital Central DE Asturias, Oviedoxx
      Sweden
      Data provided via Scandiatransplant.
      University Hospital of Lundxx
      Sahlgrenska University Hospitalxx
      University Hospital Zurichx
      University Clinic for Cardio Thoracic Surgery, Baselx
      TaiwanChina Medical College Hospitalx
      United Kingdom
      Data provided via UK Transplant.
      Great Ormand Street Hospital for Childrenxx
      University of Glasgow/Glasgow Royal InfirmaryxX
      Northern General Hospitalx
      Freeman Hospitalxx
      Harefield Hospitalxx
      Wythenshawe Hospitalxx
      Queen Elizabeth Hospitalxx
      Papworth Hospitalxx
      United States
      Data provided via United Network for Organ Sharing (UNOS).
      University of Alabama Hospitalxx
      Baptist Medical Center, Little Rockxx
      Arkansas Children’s Hospitalxx
      University Hospital of Arkansasxx
      University Medical Center, University of Arizonaxx
      Children’s Hospital Los Angelesxx
      Cedars Sinai Medical Centerxx
      Loma Linda University Medical Centerxx
      California Pacific Medical Centerxx
      UCSD Medical Centerxx
      University of California San Francisco Medical Centerxx
      Sutter Memorial Hospitalxx
      Sharp Memorial Hospitalxx
      Stanford University Medical Centerxx
      St Vincent Medical Centerxx
      UCLA Medical Centerxx
      USC University Hospitalxx
      Children’s Hospital, Denverxx
      University Hospital, Denverxx
      Hartford Hospitalxx
      Yale New Haven Hospitalxx
      Children’s National Medical Centerx
      Washington Hospital Centerxx
      All Children’s Hospitalxx
      Jackson Memorial Hospitalxx
      St Luke’s Hospital, Jacksonvillex
      Tampa General Hospitalxx
      Tallahassee Memorial Hospitalxx
      Shands Hospital at University of Floridaxx
      Children’s Healthcare of Atlantaxx
      Emory University Hospitalxx
      St Joseph Hospital of Atlantaxx
      St Francis Medical Center, Honoluluxx
      University of lowa Hospital and Clinicsxx
      Children’s Memorial Hospitalxx
      Loyola University Medical Centerxx
      OSF St Francis Medical Centerxx
      St. John’s Hospitalx
      University of Chicago Medical Centerxx
      University of Illinois Hospitalxx
      Clarian Health-Methodist/IU/Rileyxx
      Lutheran Hospital of Ft Waynexx
      St Vincent Hospital and Health Care Centerxx
      Via Christi Regional Medical Centerxx
      Jewish Hospitalxx
      Kosair Children’s Hospitalx
      University of Kentucky Medical Centerxx
      Ochsner Foundation Hospitalxx
      Tulane University Medical Centerxx
      Willis Knighton Medical Centerxx
      Children’s Hospital, Bostonxx
      Massachusetts General Hospitalxx
      New England Medical Centerxx
      Brigham and Women’s Hospitalxx
      UMass Memorial Medical Centerx
      Johns Hopkins Hospitalxx
      University of Maryland Medical Systemxx
      Children’s Hospital of Michiganxx
      Henry Ford Hospitalxx
      University of Michigan Medical Centerxx
      Abbott Northwestern Hospitalxx
      St Mary’s Hospital (Mayo Clinic)xx
      Fairview University Medical Centerxx
      Barnes-Jewish Hospitalxx
      Cardinal Glennon Children’s Hospitalxx
      St Louis Children’s Hospitalxx
      St Luke’s Hospital of Kansas Cityxx
      St Louis University Hospitalxx
      University of Missouri Hospital and Clinicxx
      University of Mississippi Medical Centerxx
      North Carolina Baptist Hospitalxx
      Carolinas Medical Centerxx
      Duke University Medical Centerxx
      University of North Carolina Hospitalsxx
      Bryan LGH Medical Center Eastxx
      Newark Beth Israel Medical Centerxx
      Robert Wood Johnson Univ. Hospxx
      Presbyterian Hospital, Albuquerquexx
      Albany Medical Center Hospitalxx
      Presbyterian Hospital, New York Cityxx
      Strong Memorial Hospitalxx
      Montefiore Medical Centerxx
      Mt Sinai Medical Centerxx
      New York University Medical Centerx
      Westchester County Medical Centerxx
      Cleveland Clinic Foundationxx
      Children’s Hospital Daytonx
      Children’s Hospital Medical Center, Cincinnatixx
      Medical College Hospital, Toledoxx
      Ohio State University Hospitalxx
      University of Cincinnati Medical Centerxx
      University Hospital of Clevelandxx
      Integris Baptist Medical Centerxx
      St Francis Hospital, Tulsaxx
      Providence Portland Medical Centerxx
      Oregon Health Sciences University Hospitalxx
      Allegheny General Hospitalxx
      Children’s Hospital of Pittsburghxx
      Children’s Hospital of Philadelphiaxx
      Penn State Milton S. Hershey Medical Centerxx
      Hahnemann University Hospital Tenetxx
      University of Pittsburgh Medical Centerxx
      Temple University Hospitalxx
      Hospital of the University of Pennsylvaniaxx
      Cardiovascular Center of PRxx
      Medical University of South Carolinaxx
      Baptist Memorial Hosp, Memphisxx
      St Thomas Hospitalxx
      Vanderbilt University Medical Centerxx
      Brooke Army Medical Centerx
      University Hospital, San Antonioxx
      Children’s Medical Center of Dallasxx
      Seton Medical Centerxx
      Columbia Hospital at Medical City Dallasxx
      St Luke’s Episcopal Hospitalxx
      Methodist Specialty & Transplant Hospitalxx
      University of Texas Medical Branchxx
      Methodist Hospital, Houstonxx
      Christus Santa Rosa Medical Centerxx
      St Paul University Hospitalxx
      Texas Children’s Hospital Dallasx
      Baylor University Medical Centerxx
      LDS Hospitalxx
      University of Utah Medical Centerxx
      Primary Children’s Medical Centerxx
      Inova Fairfax Hospitalxx
      Henrico Doctors Hospitalxx
      MCV Hospitalsxx
      McGuire VA Medical Centerxx
      Sentara Norfolk General Hospitalxx
      University of Virginia HSCxx
      Children’s Hospital Medical Center, Seattlexx
      Sacred Heart Medical Centerxx
      University of Washington Medical Centerxx
      Children’s Hospital of Wisconsinxx
      Froedtert Memorial Lutheran Hospitalxx
      St Luke’s Medical Centerxx
      University of Wisconsin Hospital and Clinicsxx
      a Data provided via Australia and New Zealand Cardiothoracic Transplant Registry (ANZCTR).
      b Data provided via Eurotransplant.
      c Data provided via Scandiatransplant.
      d Data provided via UK Transplant.
      e Data provided via United Network for Organ Sharing (UNOS).