Advertisement
The Journal of Heart and Lung Transplantation
International Society for Heart and Lung Transplantation.
Advanced searchSave search
Letter to the Editor| Volume 25, ISSUE 2, P257-258, February 2006

Radiation therapy–related cardiovascular disease

DOI:https://doi.org/10.1016/j.healun.2005.04.010
Radiation therapy–related cardiovascular disease
Previous ArticlePressure–volume analysis during axial flow ventricular assist device support
Next ArticleConcomitant post-transplantation lymphoproliferative disease and therapy-related myelodysplastic syndrome after lung transplantation
      We recently encountered a middle-aged male patient who developed severe proximal coronary artery disease, moderate aortic stenosis and constrictive pericarditis 28 years after receiving radiation therapy for non-Hodgkin’s lymphoma. Cardiovascular disease related to chest radiation is being recognized as a relatively common manifestation where the absolute risk increases in proportion to the length of time from exposure.
      • Applefeld M.M.
      • Wiernik P.H.
      Cardiac disease after radiation therapy for Hodgkin’s disease analysis of 48 patients.
      Am J Cardiol. 1983; 51: 1679-1681
      , 
      • Piovaccari G.
      • Ferretti R.M.
      • Prati F.
      • et al.
      Cardiac disease after chest irradiation for Hodgkin’s disease incidence in 108 patients with long follow-up.
      Int J Cardiol. 1995; 49: 39-43
      , 
      • Carlson R.G.
      • Mayfield W.R.
      • Normann S.
      • Alexander J.A.
      Radiation-associated valvular disease.
      Chest. 1991; 99: 538-545
      , 
      • Adams M.J.
      • Hardenbergh P.H.
      • Constine L.S.
      • Lipshultz S.E.
      Radiation-associated cardiovascular disease.
      Crit Rev Oncol Hematol. 2003; 45: 55-75
      Pericardial disease is the most frequently described cardiac lesion, occurring in 50% of patients.
      • Applefeld M.M.
      • Wiernik P.H.
      Cardiac disease after radiation therapy for Hodgkin’s disease analysis of 48 patients.
      Am J Cardiol. 1983; 51: 1679-1681
      Other lesions include valvular disease, myocardial fibrosis, conduction system disease, ventricular dysfunction, accelerated or premature coronary artery disease (CAD) and carotid or subclavian artery disease.
      • Piovaccari G.
      • Ferretti R.M.
      • Prati F.
      • et al.
      Cardiac disease after chest irradiation for Hodgkin’s disease incidence in 108 patients with long follow-up.
      Int J Cardiol. 1995; 49: 39-43
      , 
      • Handa N.
      • McGregor C.G.
      • Danielson G.K.
      • et al.
      Valvular heart operation in patients with previous mediastinal radiation therapy.
      Ann Thorac Surg. 2001; 71: 1880-1884
      , 
      • McEniery P.T.
      • Dorosti K.
      • Schiavone W.A.
      • Pedrick T.J.
      • Sheldon W.C.
      Clinical and angiographic features of coronary artery disease after chest irradiation.
      Am J Cardiol. 1987; 60: 1020-1024
      , 
      • Stewart J.R.
      • Fajardo L.F.
      Radiation-induced heart disease an update.
      Progr Cardiovasc Dis. 1984; 27: 173-194
      , 
      • Hull M.C.
      • Morris C.G.
      • Pepine C.J.
      • Mendenhall N.P.
      Valvular dysfunction and carotid, subclavian, and coronary artery disease in survivors of Hodgkin lymphoma treated with radiation therapy.
      JAMA. 2003; 290: 2831-2837
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to The Journal of Heart and Lung Transplantation
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Applefeld M.M.
        • Wiernik P.H.
        Cardiac disease after radiation therapy for Hodgkin’s disease.
        Am J Cardiol. 1983; 51: 1679-1681
        View in Article
        • Piovaccari G.
        • Ferretti R.M.
        • Prati F.
        • et al.
        Cardiac disease after chest irradiation for Hodgkin’s disease.
        Int J Cardiol. 1995; 49: 39-43
        View in Article
        • Carlson R.G.
        • Mayfield W.R.
        • Normann S.
        • Alexander J.A.
        Radiation-associated valvular disease.
        Chest. 1991; 99: 538-545
        View in Article
        • Adams M.J.
        • Hardenbergh P.H.
        • Constine L.S.
        • Lipshultz S.E.
        Radiation-associated cardiovascular disease.
        Crit Rev Oncol Hematol. 2003; 45: 55-75
        View in Article
        • Handa N.
        • McGregor C.G.
        • Danielson G.K.
        • et al.
        Valvular heart operation in patients with previous mediastinal radiation therapy.
        Ann Thorac Surg. 2001; 71: 1880-1884
        View in Article
        • McEniery P.T.
        • Dorosti K.
        • Schiavone W.A.
        • Pedrick T.J.
        • Sheldon W.C.
        Clinical and angiographic features of coronary artery disease after chest irradiation.
        Am J Cardiol. 1987; 60: 1020-1024
        View in Article
        • Stewart J.R.
        • Fajardo L.F.
        Radiation-induced heart disease.
        Progr Cardiovasc Dis. 1984; 27: 173-194
        View in Article
        • Hull M.C.
        • Morris C.G.
        • Pepine C.J.
        • Mendenhall N.P.
        Valvular dysfunction and carotid, subclavian, and coronary artery disease in survivors of Hodgkin lymphoma treated with radiation therapy.
        JAMA. 2003; 290: 2831-2837
        View in Article
        • Annest L.S.
        • Anderson R.P.
        • Li W.
        • Hafermann M.D.
        Coronary artery disease following mediastinal radiation therapy.
        J Thorac Cardiovasc Surg. 1983; 85: 257-263
        View in Article
        • Heidenreich P.A.
        • Hancock S.L.
        • Lee B.K.
        • Mariscal C.S.
        • Schnittger I.
        Asymptomatic cardiac disease following mediastinal irradiation.
        JAMA. 2003; 42: 743-749
        View in Article
        • Ling L.H.
        • Oh J.K.
        • Schaff H.V.
        • et al.
        Constrictive pericarditis in the modern era.
        Circulation. 1999; 100: 1380-1386
        View in Article
        • Reinders J.G.
        • Heijmen B.J.
        • Olofsen-van Acht M.J.
        • van Putten W.L.
        • Levendag P.C.
        Ischemic heart disease after mantlefield irradiation for Hodgkin’s disease in long-term follow-up.
        Radiother Oncol. 1999; 51: 35-42
        View in Article

      Article info

      Identification

      DOI: https://doi.org/10.1016/j.healun.2005.04.010

      Copyright

      © 2006 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.

      ScienceDirect

      Access this article on ScienceDirect

      The content on this site is intended for healthcare professionals.


      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the Cookie Preference Center for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties.


      RELX