| Special Features |
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The dawn of the ISHLT Mechanical Assisted Circulatory Support (IMACS) Registry: Fulfilling our mission
ISHLT Mission Statement: The International Society of Heart and Lung Transplantation is a multidisciplinary, professional organization dedicated to improving the care of patients with advanced heart o...
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James K. Kirklin,
Mandeep R. Mehra
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115-116
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The Fourth INTERMACS Annual Report: 4,000 implants and counting
The Fourth Annual Report of the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) summarizes and analyzes the first 5 years of patient and data collection. With more than ...
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James K. Kirklin,
David C. Naftel,
Robert L. Kormos,
Lynne W. Stevenson,
Francis D. Pagani,
Marissa A. Miller,
J. Timothy Baldwin,
James B. Young
et al.
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117-126
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| Original Clinical Science |
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Use of sublingual tacrolimus in lung transplant recipients
19 December 2011
Background: In lung transplant recipients (LTRs), tacrolimus is often utilized as a core component of immunosuppressive regimens. Although tacrolimus can be delivered orally or intravenously, oral tac...
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Katherine D. Watkins,
Rebecca F. Boettger,
Katherine M. Hanger,
Lorriana E. Leard,
Jeffrey A. Golden,
Charles W. Hoopes,
Jonathan P. Singer
et al.
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127-132
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Comparison of risk factors and outcomes for pediatric patients listed for heart transplantation after bidirectional Glenn and after Fontan: An analysis from the Pediatric Heart Transplant Study
15 December 2011
Background: Patients listed for transplant after the bidirectional Glenn (BDG) may have better outcomes than patients listed after Fontan. This study examined and compared outcomes after listing for B...
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Joshua R. Kovach,
David C. Naftel,
F. Bennett Pearce,
Margaret A. Tresler,
R. Erik Edens,
Jeffrey H. Shuhaiber,
Elizabeth D. Blume,
Francis Fynn-Thompson,
James K. Kirklin,
Steven D. Zangwill
et al.
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133-139
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Decision tree for adjuvant right ventricular support in patients receiving a left ventricular assist device
15 December 2011
Background: Right ventricular (RV) failure is a significant complication after implantation of a left ventricular assist device (LVAD). It is therefore important to identify patients at risk a priori....
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Yajuan Wang,
Marc A. Simon,
Pramod Bonde,
Bronwyn U. Harris,
Jeffrey J. Teuteberg,
Robert L. Kormos,
James F. Antaki
et al.
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140-149
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Usefulness of first-line combination therapy with epoprostenol and bosentan in pulmonary arterial hypertension: An observational study
05 December 2011
Background: Recent guidelines have proposed first-line combination therapy as a potential strategy for the treatment of functional class IV pulmonary arterial hypertension (PAH). Methods: We analyzed ...
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Kristina Kemp,
Laurent Savale,
Dermot S. O'Callaghan,
Xavier Jaïs,
David Montani,
Marc Humbert,
Gérald Simonneau,
Olivier Sitbon
et al.
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150-158
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Evaluation of valganciclovir pharmacokinetics in lung transplant recipients
Background: Valganciclovir is commonly used for cytomegalovirus prevention after lung transplantation. The pharmacokinetic profile of valganciclovir in lung transplant patients has not been well descr...
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Tyree H. Kiser,
Douglas N. Fish,
Martin R. Zamora
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159-166
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Extremes of body mass index do not impact mid-term survival after continuous-flow left ventricular assist device implantation
Background: Extremes of body mass index (BMI) are often considered contraindications to use of a left ventricular assist device (LVAD), but data regarding outcomes across the spectrum of BMI are limit...
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Robert J. Brewer,
David E. Lanfear,
Chittoor B. Sai-Sudhakar,
Kartik S. Sundareswaran,
Yazhini Ravi,
David J. Farrar,
Mark S. Slaughter
et al.
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167-172
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ABO-incompatible heart transplantation: Analysis of the Pediatric Heart Transplant Study (PHTS) database
Background: ABO incompatible (ABOi) heart transplantation is an accepted approach to increasing organ availability for young patients. Previous studies have suggested that early survival for ABOi tran...
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Heather T. Henderson,
Charles E. Canter,
William T. Mahle,
Anne I. Dipchand,
Kelci LaPorte,
Kenneth B. Schechtman,
Jie Zheng,
Alfred Asante-Korang,
Rakesh K. Singh,
Kirk R. Kanter
et al.
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173-179
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Peripartum cardiomyopathy: Post-transplant outcomes from the united network for organ sharing database
Background: Nearly 25% of patients with peripartum cardiomyopathy (PPCM) will require cardiac transplantation. Whether post-transplant outcomes differ among patients with PPCM compared with other reci...
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Kismet Rasmusson,
Kim Brunisholz,
Deborah Budge,
Benjamin D. Horne,
Rami Alharethi,
Jan Folsom,
Jenny J. Connolly,
Josef Stehlik,
Abdallah Kfoury
et al.
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180-186
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| Original Pre-Clinical Science |
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Reconditioning of lungs donated after circulatory death with normothermic ex vivo lung perfusion
Background: The use of donation-after-circulatory-death (DCD) donors for lung transplantation has come into practice. In this study we investigated whether DCD lungs can be resuscitated after warm isc...
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Daisuke Nakajima,
Fengshi Chen,
Tetsu Yamada,
Jin Sakamoto,
Akihiro Ohsumi,
Toru Bando,
Hiroshi Date
et al.
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187-193
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Effect of simvastatin on development of obliterative airway disease: An experimental study
Background: Obliterative bronchiolitis after lung transplantation is characterized by airway inflammation leading to obliteration of small airways. Statins are known to have lipid-independent immunomo...
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Jussi O. Ropponen,
Simo O. Syrjälä,
Maria Hollmén,
Raimo Tuuminen,
Rainer Krebs,
Mikko A. Keränen,
Kirsi Vaali,
Antti I. Nykänen,
Karl B. Lemström,
Jussi M. Tikkanen
et al.
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194-203
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Construction of vascularized cardiac tissue from genetically modified mouse embryonic stem cells
Background: The aim of myocardial tissue engineering is to repair or regenerate damaged myocardium with engineered cardiac tissue constructed by a combination of cells and scaffolds in vitro. However,...
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Wenjun He,
Lingling Ye,
Shichong Li,
Hong Liu,
Benchuan Wu,
Qiwei Wang,
Xiaobing Fu,
Weidong Han,
Zhaolie Chen
et al.
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204-212
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Searching for novel molecular targets of chronic rejection in an orthotopic experimental lung transplantation model
Background: Chronic rejection (CR) is the main reason for the limited survival rates among lung transplant (LT) recipients. There remains no effective treatment for CR. The aim of this study was to id...
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Norberto Santana-Rodríguez,
Ricardo García-Herrera,
Bernardino Clavo,
Pedro Llontop,
Miguel A. Ponce-González,
Jesús Villar,
Ana López-García,
María D. Fiuza,
Juan C. Rodríguez-Bermejo,
José M. García-Castellano,
Rubén P. Machín,
José A. Ruíz-Caballero,
Yanira Brito,
Leandro Fernández-Pérez
et al.
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213-221
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Altered progenitor cell and cytokine profiles in bronchiolitis obliterans syndrome
Background: Bone marrow–derived progenitor cells may play a key role in both lung repair and in fibrogenesis. The contribution of CD45+collagen-1+ fibrocytes to fibrosis has been documented elsewhere ...
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Sarah E. Gilpin,
Kalvin C. Lung,
Masaaki Sato,
Lianne G. Singer,
Shaf Keshavjee,
Thomas K. Waddell
et al.
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222-228
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| Comment and Opinion |
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Combined heart and liver transplantation in an adult with familial heterozygous hypercholesterolemia and severe ischemic cardiomyopathy
Familial hypercholesterolemia (FH) is an autosomal-dominant disorder caused by mutations in the low-density lipoprotein (LDL) receptor. The clinical manifestations of FH include severe atherosclerosis...
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Snehal R. Patel,
David D'alessandro,
Jooyoung J. Shin
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229
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| Frontmatter |
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Editorial Board
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A1
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Contents
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A4
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