The Journal of Heart and Lung Transplantation
Volume 31, Issue 1 , Pages 1-8 , January 2012

Pre-operative and post-operative risk factors associated with neurologic complications in patients with advanced heart failure supported by a left ventricular assist device

  • Tomoko S. Kato, MD, PhD

      Affiliations

    • Division of Cardiology, Department of Medicine, Department of Surgery, Columbia University Medical Center, New York, New York
    • Department of Cardiovascular Medicine and Organ Transplantation, National Cerebral and Cardiovascular Center, Osaka, Japan
    • Corresponding Author InformationReprint requests: Tomoko S. Kato, MD, PhD, Columbia University Medical Center, NY Presbyterian Hospital, Department of Medicine, Division of Cardiology, Center for Advanced Cardiac Care, 622 W 168th St, PH-1265, New York, NY 10032. Telephone: 212-342-3503. Fax: 212-305-8304
    • ,
  • P. Christian Schulze, MD, PhD

      Affiliations

    • Division of Cardiology, Department of Medicine, Department of Surgery, Columbia University Medical Center, New York, New York
    • ,
  • Jonathan Yang, MD

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York
    • ,
  • Ernest Chan, BS

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York
    • ,
  • Khurram Shahzad, MD

      Affiliations

    • Division of Cardiology, Department of Medicine, Department of Surgery, Columbia University Medical Center, New York, New York
    • ,
  • Hiroo Takayama, MD, PhD

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York
    • ,
  • Nir Uriel, MD

      Affiliations

    • Division of Cardiology, Department of Medicine, Department of Surgery, Columbia University Medical Center, New York, New York
    • ,
  • Ulrich Jorde, MD

      Affiliations

    • Division of Cardiology, Department of Medicine, Department of Surgery, Columbia University Medical Center, New York, New York
    • ,
  • Maryjane Farr, MD

      Affiliations

    • Division of Cardiology, Department of Medicine, Department of Surgery, Columbia University Medical Center, New York, New York
    • ,
  • Yoshifumi Naka, MD, PhD

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York
    • ,
  • Donna Mancini, MD

      Affiliations

    • Division of Cardiology, Department of Medicine, Department of Surgery, Columbia University Medical Center, New York, New York

References 

  1. Stehlik J , Edwards LB , Kucheryavaya AY , et al.  The Registry of the International Society for Heart and Lung Transplantation: twenty-seventh official adult heart transplant report—2010 . J Heart Lung Transplant . 2010;29:1089–1103
  2. Jaski BE , Kim JC , Naftel DC , et al. Cardiac Transplant Research Database Research Group   Cardiac transplant outcome of patients supported on left ventricular assist device vs intravenous inotropic therapy . J Heart and Lung Transplant . 2001;20:449–456
  3. Goldstein DJ , Oz MC , Rose EA . Implantable left ventricular assist devices . N Engl J Med . 1998;339:1522–1533
  4. Rose EA , Gelijns AC , Moskowitz AJ , et al. Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) Study Group   Long-term use of a left ventricular assist device for end-stage heart failure . N Engl J Med . 2001;345:1435–1443
  5. Slaughter MS , Rogers JG , Milano CA , et al. HeartMate II Investigators   Advanced heart failure treated with continuous-flow left ventricular assist device . N Engl J Med . 2009;361:2241–2251
  6. Birks EJ , Yacoub MH , Banner NR , Khaghani A . The role of bridge to transplantation: should LVAD patients be transplanted? . Curr Opin Cardiol . 2004;19:148–153
  7. Birks EJ , Tansley PD , Hardy J , et al.  Left ventricular assist device and drug therapy for the reversal of heart failure . N Engl J Med . 2006;355:1873–1884
  8. Holman WL , Kormos RL , Naftel DC , et al.  Predictors of death and transplant in patients with a mechanical circulatory support device: a multi-institutional study . J Heart Lung Transplant . 2009;28:44–50
  9. Nakajima I , Kato TS , Komamura K , et al.  Pre- and post-operative risk factors associated with cerebrovascular accidents in patients supported by left ventricular assist device . Circ J . 2011;25:1138–1146
  10. John R , Kamdar F , Liao K , Colvin-Adams M , Boyle A , Joyce L . Improved survival and decreasing incidence of adverse events with the HeartMate II left ventricular assist device as bridge-to-transplant therapy . Ann Thorac Surg . 2008;86:1227–1234
  11. Tsukui H , Abla A , Teuteberg JJ , et al.  Cerebrovascular accidents in patients with a ventricular assist device . J Thorac Cardiovasc Surg . 2007;134:114–123
  12. Kirklin JK , Naftel DC , Stevenson LW , et al.  INTERMACS database for durable devices for circulatory support: first annual report . J Heart Lung Transplant . 2008;27:1065–1072
  13. Kirklin JK , Naftel DC , Kormos RL , et al.  Second INTERMACS annual report: more than 1,000 primary left ventricular assist device implants . J Heart Lung Transplant . 2010;29:1–10
  14. Mehta JL , Saldeen TG , Rand K . Interactive role of infection, inflammation and traditional risk factors in atherosclerosis and coronary artery disease . J Am Coll Cardiol . 1998;31:1217–1225
  15. Frishman WH , Ismail AA . Role of infection in atherosclerosis and coronary artery disease: a new therapeutic target? . Cardiol Rev . 2002;10:199–210
  16. Syrjänen J . Infection as a risk factor for cerebral infarction . Eur Heart J . 1993;14(Suppl K):17–19
  17. Kannoth S , Iyer R , Thomas SV , et al.  Intracranial infectious aneurysm: presentation, management and outcome . J Neurol Sci . 2007;256:3–9
  18. Uthamalingam S , Kandala J , Daley M , et al.  Serum albumin and mortality in acutely decompensated heart failure . Am Heart J . 2010;160:1149–1155
  19. Horwich TB , Kalantar-Zadeh K , MacLellan RW , Fonarow GC . Albumin levels predict survival in patients with systolic heart failure . Am Heart J . 2008;155:883–889
  20. Blair JE , Zannad F , Konstam MA , et al. EVEREST Investigators   Continental differences in clinical characteristics, management, and outcomes in patients hospitalized with worsening heart failure results from the EVEREST (Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study with Tolvaptan) program . J Am Coll Cardiol . 2008;52:1640–1648
  21. Gheorghiade M , Abraham WT , Albert NM , et al. OPTIMIZE-HF Investigators and Coordinators   Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure: an analysis from the OPTIMIZE-HF registry . Eur Heart J . 2007;28:980–988
  22. Vrtovec B , Radovancevic R , Delgado RM , et al.  Significance of anaemia in patients with advanced heart failure receiving long-term mechanical circulatory support . Eur J Heart Fail . 2009;11:1000–1004
  23. Alba AC , Rao V , Ivanov J , Ross HJ , Delgado DH . Usefulness of the INTERMACS scale to predict outcomes after mechanical assist device implantation . J Heart Lung Transplant . 2009;28:827–833
  24. Boyle AJ , Ascheim DD , Russo MJ , et al.  Clinical outcomes for continuous-flow left ventricular assist device patients stratified by pre-operative INTERMACS classification . J Heart Lung Transplant . 2011;30:402–407

PII: S1053-2498(11)01116-8

doi: 10.1016/j.healun.2011.08.014

The Journal of Heart and Lung Transplantation
Volume 31, Issue 1 , Pages 1-8 , January 2012

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