The Journal of Heart and Lung Transplantation
Volume 29, Issue 12 , Pages 1415-1426 , December 2010

Dose-dependent systolic contribution of differentiated stem cells in post-infarct ventricular function

  • Winston S.N. Shim, PhD

      Affiliations

    • Research and Development Unit, National Heart Center, Singapore
    • Corresponding Author InformationReprint requests: Winston S. N. Shim, PhD, National Heart Centre, 9 Hospital Dr, Block C, Level 3, Suite 02, Singapore 169612. Telephone: 65-6435-0752, Fax: 65-6226-3972
    • ,
  • Genevieve Tan, BSc

      Affiliations

    • Research and Development Unit, National Heart Center, Singapore
    • Department of Surgery, National University of Singapore, Singapore
    • ,
  • Yacui Gu, MD

      Affiliations

    • Research and Development Unit, National Heart Center, Singapore
    • ,
  • Ling Qian, BSc

      Affiliations

    • Research and Development Unit, National Heart Center, Singapore
    • ,
  • Shiqi Li, MD

      Affiliations

    • Research and Development Unit, National Heart Center, Singapore
    • ,
  • Ying Ying Chung, BSc

      Affiliations

    • Research and Development Unit, National Heart Center, Singapore
    • ,
  • Sze Yun Lim, BSc

      Affiliations

    • Research and Development Unit, National Heart Center, Singapore
    • ,
  • Eugene Sim, MBBS

      Affiliations

    • Department of Surgery, National University of Singapore, Singapore
    • ,
  • Seng Chye Chuah, MBBS

      Affiliations

    • Department of Cardiology, National Heart Center, Singapore
    • ,
  • Philip Wong, MBBS

      Affiliations

    • Department of Cardiology, National Heart Center, Singapore

References 

  1. Diederichsen AC, Moller JE, Thayssen P, et al. Effect of repeated intracoronary injection of bone marrow cells in patients with ischaemic heart failure The Danish Stem Cell study-Congestive Heart Failure trial (DanCell-CHF). Eur J Heart Fail. 2008;10:661–667
  2. Wollert KC, Meyer GP, Lotz J, et al. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet. 2004;364:141–148
  3. Janssens S, Dubois C, Bogaert J, et al. Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial. Lancet. 2006;367:113–121
  4. Stamm C, Westphal B, Kleine HD, et al. Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet. 2003;361:45–46
  5. Perin EC, Silva GV. Autologous cell-based therapy for ischemic heart disease: Clinical evidence, proposed mechanisms of action, and current limitations. Catheter Cardiovasc Interv. 2008;73:281–288
  6. Jackson KA, Majka SM, Wang H, et al. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest. 2001;107:1395–1402
  7. Orlic D, Kajstura J, Chimenti S, et al. Bone marrow cells regenerate infarcted myocardium. Nature. 2001;410:701–705
  8. Toma C, Pittenger MF, Cahill KS, et al. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation. 2002;105:93–98
  9. Nishida M, Li TS, Hirata K, et al. Improvement of cardiac function by bone marrow cell implantation in a rat hypoperfusion heart model. Ann Thorac Surg. 2003;75:768–773discussion 773-4
  10. Tse HF, Kwong YL, Chan JK, et al. Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation. Lancet. 2003;361:47–49
  11. Gojo S, Gojo N, Takeda Y, et al. In vivo cardiovasculogenesis by direct injection of isolated adult mesenchymal stem cells. Exp Cell Res. 2003;288:51–59
  12. Tomita S, Mickle DA, Weisel RD, et al. Improved heart function with myogenesis and angiogenesis after autologous porcine bone marrow stromal cell transplantation. J Thorac Cardiovasc Surg. 2002;123:1132–1140
  13. Shim WS, Jiang S, Wong P, et al. Ex vivo differentiation of human adult bone marrow stem cells into cardiomyocyte-like cells. Biochem Biophys Res Commun. 2004;324:481–488
  14. Wang T, Xu Z, Jiang W, et al. Cell-to-cell contact induces mesenchymal stem cell to differentiate into cardiomyocyte and smooth muscle cell. Int J Cardiol. 2006;109:74–81
  15. Forte G M, Minieri M, Cossa P, et al. Hepatocyte growth factor effects on mesenchymal stem cells: proliferation, migration, and differentiation. Stem Cells. 2006;24:23–33
  16. Li X, Yu X, Lin Q, et al. Bone marrow mesenchymal stem cells differentiate into functional cardiac phenotypes by cardiac microenvironment. J Mol Cell Cardiol. 2007;42:295–303
  17. Pacher P, Mabley HG, Liaudet L, et al. Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failure. Am J Physiol Heart Circ Physiol. 2004;287:H2132–H2137
  18. Shim WS, Li W, Zhang L, et al. Angiopoietin-1 promotes functional neovascularization that relieves ischemia by improving regional reperfusion in a swine chronic myocardial ischemia model. J Biomed Sci. 2006;13:579–591
  19. Peirce SM, Price RJ, Skalak TC. Spatial and temporal control of angiogenesis and arterialization using focal applications of VEGF164 and Ang-1. Am J Physiol Heart Circ Physiol. 2004;286:H918–H925
  20. Shim WS, Lim SY, Li SQ, et al. Structural stability of neoangiogenic intramyocardial microvessels supports functional recovery in chronic ischemic myocardium. J Mol Cell Cardiol. 2008;45:70–80
  21. Hirata Y, Sata M, Motomura N, et al. Human umbilical cord blood cells improve cardiac function after myocardial infarction. Biochem Biophys Res Commun. 2005;327:609–614
  22. Lunde K, Solheim S, Forfang K, et al. Anterior myocardial infarction with acute percutaneous coronary intervention and intracoronary injection of autologous mononuclear bone marrow cells: safety, clinical outcome, and serial changes in left ventricular function during 12-months' follow-up. J Am Coll Cardiol. 2008;51:674–676
  23. Penicka M, Horak J, Kobylka P, et al. Intracoronary injection of autologous bone marrow-derived mononuclear cells in patients with large anterior acute myocardial infarction: a prematurely terminated randomized study. J Am Coll Cardiol. 2007;49:2373–2374
  24. Panovsky R, Meluzin J, Janousek S, et al. Cell therapy in patients with left ventricular dysfunction due to myocardial infarction. Echocardiography. 2008;25:888–897
  25. Meluzin J, Janousek S, Mayer J, et al. Three-, 6-, and 12-month results of autologous transplantation of mononuclear bone marrow cells in patients with acute myocardial infarction. Int J Cardiol. 2008;128:185–192
  26. Mollmann H, Nef HM, Kostin S, et al. Bone marrow-derived cells contribute to infarct remodelling. Cardiovasc Res. 2006;71:661–671
  27. Tan G, Shim W, Gu Y. Differential effect of myocardial matrix and integrins on cardiac differentiation of human mesenchymal stem cells. Differentiation. 2010;79:260–271
  28. Andrade J, Lam JT, Zamora M, et al. Predominant fusion of bone marrow-derived cardiomyocytes. Cardiovasc Res. 2005;68:387–393
  29. Nygren JM, Jovinge S, Breitbach M, et al. Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat Med. 2004;10:494–501
  30. Mills WR, Mal N, Kiedrowski MJ, et al. Stem cell therapy enhances electrical viability in myocardial infarction. J Mol Cell Cardiol. 2007;42:304–314
  31. Shyu KG, Wang BW, Hung HF, et al. Mesenchymal stem cells are superior to angiogenic growth factor genes for improving myocardial performance in the mouse model of acute myocardial infarction. J Biomed Sci. 2006;13:47–58
  32. Connelly KA, Prior DL, Kelly DJ, et al. Load-sensitive measures may overestimate global systolic function in the presence of left ventricular hypertrophy: a comparison with load-insensitive measures. Am J Physiol Heart Circ Physiol. 2006;290:H1699–H1705

PII: S1053-2498(10)00397-9

doi: 10.1016/j.healun.2010.06.009

The Journal of Heart and Lung Transplantation
Volume 29, Issue 12 , Pages 1415-1426 , December 2010

Article Tools

* Image Usage & Resolution