The Journal of Heart and Lung Transplantation
Volume 29, Issue 12 , Pages 1321-1329 , December 2010

Aortic valve pathophysiology during left ventricular assist device support

  • Ranjit John, MD

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota, Minneapolis, Minnesota
    • Corresponding Author InformationReprint requests: Ranjit John, MD, Division of Cardiothoracic Surgery, University of Minnesota Minneapolis, MN 55455. Telephone: 612-626-3664. Fax: 612-625-1683
    • ,
  • Katie Mantz, BS

      Affiliations

    • Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota
    • ,
  • Peter Eckman, MD

      Affiliations

    • Department of Medicine, University of Minnesota, Minneapolis, Minnesota
    • ,
  • Alan Rose, MD

      Affiliations

    • Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota
    • ,
  • Karen May-Newman, PhD

      Affiliations

    • Bioengineering Program, Department of Mechanical Engineering, San Diego State University, San Diego

  • Image Result

    Transvalvular pressure for three different blood flow paths through the heart: normal (no LVAD), series, and parallel. The time series were obtained by subtracting the left ventricular pressure from t

    Transvalvular pressure for three different blood flow paths through the heart: normal (no LVAD), series, and parallel. The time series were obtained by subtracting the left ventricular pressure from the aortic pressure for several cardiac cycles.

  • Image Result
    (A) When the aortic valve does not open, the left ventricle (LV) functions in series with the LV assist device (LVAD). (B) If the heart pumps strongly enough to open the valve, the ventricle is operat

    (A) When the aortic valve does not open, the left ventricle (LV) functions in series with the LV assist device (LVAD). (B) If the heart pumps strongly enough to open the valve, the ventricle is operating in parallel with the LVAD. LA, left atrium; RA, right atrium; RV, right ventricle.

  • Image Result
    Effect of type of normal, parallel, and series blood flow condition on area and timing of aortic valve opening.

    Effect of type of normal, parallel, and series blood flow condition on area and timing of aortic valve opening.

  • Image Result
    Acquired commissural fusion in a native aortic valve (arrow) in a patient receiving left ventricular assist device support.

    Acquired commissural fusion in a native aortic valve (arrow) in a patient receiving left ventricular assist device support.

  • Image Result
    A histologic section of the fused cusps shows light-staining collagen uniting the 2 cusps centrally (elastic stain, original magnification ×400).

    A histologic section of the fused cusps shows light-staining collagen uniting the 2 cusps centrally (elastic stain, original magnification ×400).

  • Image Result
    Our recommendations to optimally manage both native and bioprosthetic aortic valves in patients with left ventricular assist devices (LVAD).

    Our recommendations to optimally manage both native and bioprosthetic aortic valves in patients with left ventricular assist devices (LVAD).

PII: S1053-2498(10)00367-0

doi: 10.1016/j.healun.2010.06.006

The Journal of Heart and Lung Transplantation
Volume 29, Issue 12 , Pages 1321-1329 , December 2010

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