The Journal of Heart and Lung Transplantation
Volume 29, Issue 12 , Pages 1380-1387 , December 2010

Low potassium dextran is superior to University of Wisconsin solution in high-risk lung transplant recipients

  • George J. Arnaoutakis, MD

      Affiliations

    • Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland
    • ,
  • Jeremiah G. Allen, MD

      Affiliations

    • Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland
    • ,
  • Christian A. Merlo, MD MPH

      Affiliations

    • Division of Pulmonology, The Johns Hopkins Medical Institutions, Baltimore, Maryland
    • ,
  • William A. Baumgartner, MD

      Affiliations

    • Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland
    • ,
  • John V. Conte, MD

      Affiliations

    • Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland
    • ,
  • Ashish S. Shah, MD

      Affiliations

    • Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland
    • Corresponding Author InformationReprint requests: Ashish S. Shah, MD, Assistant Professor of Surgery, Division of Cardiac Surgery, The Johns Hopkins Hospital, Blalock 618, 600 N Wolfe St, Baltimore, MD 21287. Telephone: 410-502-3900. Fax: 410-955-3809

References 

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  2. TenVergert EM, Essink-Bot ML, Geertsma A, van Enckevort PJ, de Boer WJ, van der Bij W. The effect of lung transplantation on health-related quality of life: a longitudinal study. Chest. 1998;113:358–364
  3. Arcasoy SM, Kotloff RM. Lung transplantation. N Engl J Med. 1999;340:1081–1091
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  6. Christie JD, Kotloff RM, Pochettino A, et al. Clinical risk factors for primary graft failure following lung transplantation. Chest. 2003;124:1232–1241
  7. Chien S, Zhang F, Niu W, Tseng MT, Gray L. Comparison of university of wisconsin, euro-collins, low-potassium dextran, and Krebs-Henseleit solutions for hypothermic lung preservation. The Journal of thoracic and cardiovascular surgery. 2000;119:921–930
  8. Hausen B, Beuke M, Schroeder F, et al. In vivo measurement of lung preservation solution efficacy: comparison of LPD, UW, EC and low K+-EC following short and extended ischemia. Eur J Cardiothorac Surg. 1997;12:771–779discussion 779–80
  9. Kelly RF, Murar J, Hong Z, et al. Low potassium dextran lung preservation solution reduces reactive oxygen species production. Ann Thorac Surg. 2003;75:1705–1710
  10. Ganesh JS, Rogers CA, Banner NR, Bonser RS. Does the method of lung preservation influence outcome after transplantation? (An analysis of 681 consecutive procedures). J Thorac Cardiovasc Surg. 2007;134:1313–1321
  11. Oto T, Griffiths AP, Rosenfeldt F, Levvey BJ, Williams TJ, Snell GI. Early outcomes comparing Perfadex, Euro-Collins, and Papworth solutions in lung transplantation. Ann Thorac Surg. 2006;82:1842–1848
  12. Van Raemdonck D. Thoracic organs: current preservation technology and future prospects; part 1: lung. Curr Opin Organ Transplant. 2010;15:150–155
  13. Fischer S, Matte-Martyn A, De Perrot M, et al. Low-potassium dextran preservation solution improves lung function after human lung transplantation. J Thorac Cardiovasc Surg. 2001;121:594–596
  14. Weiss ES, Allen JG, Merlo CA, Conte JV, Shah AS. Lung allocation score predicts survival in lung transplantation patients with pulmonary fibrosis. Ann Thorac Surg. 2009;88:1757–1764
  15. Egan TM, Kotloff RM. Pro/Con debate: lung allocation should be based on medical urgency and transplant survival and not on waiting time. Chest. 2005;128:407–415
  16. Merlo CA, Weiss ES, Orens JB, et al. Impact of U.S. Lung Allocation Score on survival after lung transplantation. J Heart Lung Transplant. 2009;28:769–775
  17. Schulman LL, Weinberg AD, McGregor C, Galantowicz ME, Suciu-Foca NM, Itescu S. Mismatches at the HLA-DR and HLA-B loci are risk factors for acute rejection after lung transplantation. Am J Respir Crit Care Med. 1998;157:1833–1837
  18. Kreider M, Kotloff RM. Selection of candidates for lung transplantation. Proc Am Thorac Soc. 2009;6:20–27
  19. Oka T, Puskas JD, Mayer E, et al. Low-potassium UW solution for lung preservation (Comparison with regular UW, LPD, and Euro-Collins solutions). Transplantation. 1991;52:984–988
  20. Chan BB, Kron IL, Flanagan TL, Kern JA, Hobson CE, Tribble CG. Impairment of vascular endothelial function by high-potassium storage solutions. Ann Thorac Surg. 1993;55:940–945
  21. Muller C, Furst H, Reichenspurner H, Briegel J, Groh J, Reichart B. Lung procurement by low-potassium dextran and the effect on preservation injury (Munich Lung Transplant Group). Transplantation. 1999;68:1139–1143
  22. Rabanal JM, Ibanez AM, Mons R, et al. Influence of preservation solution on early lung function (Euro-Collins vs Perfadex). Transplant Proc. 2003;35:1938–1939
  23. Struber M, Wilhelmi M, Harringer W, et al. Flush perfusion with low potassium dextran solution improves early graft function in clinical lung transplantation. Eur J Cardiothorac Surg. 2001;19:190–194
  24. Nath DS, Walter AR, Johnson AC, et al. Does Perfadex affect outcomes in clinical lung transplantation?. J Heart Lung Transplant. 2005;24:2243–2248
  25. Aziz TM, Pillay TM, Corris PA, et al. Perfadex for clinical lung procurement: is it an advance?. Ann Thorac Surg. 2003;75:990–995

PII: S1053-2498(10)00355-4

doi: 10.1016/j.healun.2010.05.031

The Journal of Heart and Lung Transplantation
Volume 29, Issue 12 , Pages 1380-1387 , December 2010

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