The Journal of Heart and Lung Transplantation
Volume 29, Issue 11 , Pages 1231-1239 , November 2010

Construct validity of the definition of primary graft dysfunction after lung transplantation

  • Jason D. Christie, MD, MS

      Affiliations

    • Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • Corresponding Author InformationReprint requests: Jason D. Christie, MD, MS, Associate Professor of Medicine and Epidemiology, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, 423 Guardian Dr, 719 Blockley Hall, Philadelphia, PA 19104. Telephone: 215 573-3209. Fax: 215 573-0198
    • ,
  • Scarlett Bellamy, PhD

      Affiliations

    • Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • Lorraine B. Ware, MD

      Affiliations

    • Division of Pulmonary, Allergy, and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee
    • ,
  • David Lederer, MD

      Affiliations

    • Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, New York
    • ,
  • Denis Hadjiliadis, MD, MHS

      Affiliations

    • Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • James Lee, MD

      Affiliations

    • Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • Nancy Robinson, PhD

      Affiliations

    • Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • A. Russell Localio, PhD

      Affiliations

    • Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • Keith Wille, MD

      Affiliations

    • Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • Vibha Lama, MD

      Affiliations

    • Division of Pulmonary, Allergy, and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan
    • ,
  • Scott Palmer, MD

      Affiliations

    • Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University, Durham, North Carolina
    • ,
  • Jonathan Orens, MD

      Affiliations

    • Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Johns Hopkins University Hospital, Baltimore, Maryland
    • ,
  • Ann Weinacker, MD

      Affiliations

    • Division of Pulmonary and Critical Care Medicine, Stanford University, Palo Alto, California
    • ,
  • Maria Crespo, MD

      Affiliations

    • Division of Pulmonary and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
    • ,
  • Ejigaehu Demissie, MSN

      Affiliations

    • Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • Stephen E. Kimmel, MD, MS

      Affiliations

    • Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • Steven M. Kawut, MD, MS

      Affiliations

    • Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

  • Image Result

    Biomarkers of acute lung injury by different primary graft dysfunction (PGD) grades at 72 hours (T72): (A) protein C, (B) plasminogen activator inhibitor type 1 (PAI-1), (C) intercellular adhesion mol

    Biomarkers of acute lung injury by different primary graft dysfunction (PGD) grades at 72 hours (T72): (A) protein C, (B) plasminogen activator inhibitor type 1 (PAI-1), (C) intercellular adhesion molecule 1 (ICAM-1). The different grades appear as numbers in the lines at the different time points. Solid lines indicate Grade 0; dotted lines indicate Grade 1; dashed lines indicate Grade 2; and dash-dot lines indicate Grade 3 PGD. *p < 0.05; **p < 0.01 for Grade 3 vs the rest.

  • Image Result
    Impact of primary graft dysfunction grades at different time points on 30-day mortality rates.

    Impact of primary graft dysfunction grades at different time points on 30-day mortality rates.

  • Image Result
    Kaplan-Meier survival curves of PGD grades at different time points: (A) 24 hours (T24), (B) 48 hours (T48), and (C) 72 hours (T72).

    Kaplan-Meier survival curves of PGD grades at different time points: (A) 24 hours (T24), (B) 48 hours (T48), and (C) 72 hours (T72).

PII: S1053-2498(10)00294-9

doi: 10.1016/j.healun.2010.05.013

The Journal of Heart and Lung Transplantation
Volume 29, Issue 11 , Pages 1231-1239 , November 2010

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