The Journal of Heart and Lung Transplantation
Volume 29, Issue 9 , Pages 973-980 , September 2010

Anti-human leukocyte antigen antibodies and preemptive antibody-directed therapy after lung transplantation

  • Ramsey R. Hachem, MD

      Affiliations

    • Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, Missouri
    • Corresponding Author InformationReprint requests: Ramsey R. Hachem, MD, Washington University School of Medicine, Division of Pulmonary & Critical Care Medicine, 660 S Euclid Ave, Campus Box 8052, St. Louis, MO 63110. Telephone: 314-454-8766. Fax: 314-454-7956
    • ,
  • Roger D. Yusen, MD

      Affiliations

    • Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, Missouri
    • ,
  • Bryan F. Meyers, MD

      Affiliations

    • Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, Missouri
    • ,
  • Aviva A. Aloush, RN

      Affiliations

    • Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, Missouri
    • ,
  • Thalachallour Mohanakumar, PhD

      Affiliations

    • Department of Surgery, Washington University School of Medicine, St. Louis, Missouri
    • ,
  • G. Alexander Patterson, MD

      Affiliations

    • Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, Missouri
    • ,
  • Elbert P. Trulock, MD

      Affiliations

    • Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, Missouri

References 

  1. Christie JD, Edwards LB, Aurora P, et al. Registry of the International Society for Heart and Lung Transplantation: Twenty-fifth official adult lung and heart/lung transplantation report–2008. J Heart Lung Transplant. 2008;27:957–969
  2. Burton CM, Carlsen J, Mortensen J, Andersen CB, Milman N, Iversen M. Long-term survival after lung transplantation depends on development and severity of bronchiolitis obliterans syndrome. J Heart Lung Transplant. 2007;26:681–686
  3. Lingaraju R, Pochettino A, Blumenthal NP, et al. Lung transplant outcomes in white and African American recipients: special focus on acute and chronic rejection. J Heart Lung Transplant. 2009;28:8–13
  4. Valentine VG, Robbins RC, Berry GJ, et al. Actuarial survival of heart-lung and bilateral sequential lung transplant recipients with obliterative bronchiolitis. J Heart Lung Transplant. 1996;15:371–383
  5. Sundaresan S, Mohanakumar T, Smith MA, et al. HLA-A locus mismatches and development of antibodies to HLA after lung transplantation correlate with the development of bronchiolitis obliterans syndrome. Transplantation. 1998;65:648–653
  6. Smith MA, Sundaresan S, Mohanakumar T, et al. Effect of development of antibodies to HLA and cytomegalovirus mismatch on lung transplantation survival and development of bronchiolitis obliterans syndrome. J Thorac Cardiovac Surg. 1998;116:812–820
  7. Palmer SM, Davis RD, Hadjiliadis D, et al. Development of an antibody specific to major histocompatibility antigens detectable by flow cytometry after lung transplant is associated with bronchiolitis obliterans syndrome. Transplantation. 2002;74:799–804
  8. Girnita AL, McCurry KR, Iacono AT, et al. HLA-specific antibodies are associated with high-grade and persistent-recurrent lung allograft acute rejection. J Heart Lung Transplant. 2004;23:1135–1141
  9. Girnita AL, Duquesnoy R, Yousem SA, et al. HLA-specific antibodies are risk factors for lymphocytic bronchiolitis and chronic lung allograft dysfunction. Am J Transplant. 2005;5:131–138
  10. Jaramillo A, Smith CR, Maruyama T, Zhang L, Patterson GA, Mohanakumar T. Anti-HLA class I antibody binding to airway epithelial cells induces production of fibrogenic growth factors and apoptotic cell death: a possible mechanism for bronchiolitis obliterans syndrome. Hum Immunol. 2003;64:521–529
  11. Maruyama T, Jaramillo A, Narayanan K, Higuchi T, Mohanakumar T. Induction of obliterative airway disease by anti-HLA class I antibodies. Am J Transplant. 2005;5:2126–2134
  12. Fukami N, Ramachandran S, Saini D, et al. Antibodies to MHC class I induce autoimmunity: role in the pathogenesis of chronic rejection. J Immunol. 2009;182:309–318
  13. Morris GP, Phelan DL, Jendrisak MD, Mohanakumar T. Virtual crossmatch by identification of donor-specific anti-human leukocyte antigen antibodies by solid-phase immunoassay: a 30-month analysis in living donor kidney transplantation. Hum Immunol. 2010;71:268–273
  14. Yousem SA, Berry GJ, Cagle PT, et al. Revision of the 1990 working formulation for the classification of pulmonary allograft rejection: Lung Rejection Study Group. J Heart Lung Transplant. 1996;15:1–15
  15. Estenne M, Maurer JR, Boehler A, et al. Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria. J Heart Lung Transplant. 2002;21:297–310
  16. Tait BD, Hudson F, Cantwell L, et al. Review article: luminex technology for HLA antibody detection in organ transplantation. Nephrology. 2009;14:247–254

PII: S1053-2498(10)00287-1

doi: 10.1016/j.healun.2010.05.006

The Journal of Heart and Lung Transplantation
Volume 29, Issue 9 , Pages 973-980 , September 2010

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