The Journal of Heart and Lung Transplantation
Volume 29, Issue 9 , Pages 966-972 , September 2010

Balancing rejection and infection with respect to age, race, and gender: Clues acquired from 17 years of cardiac transplantation data

  • James F. George, PhD

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    • Corresponding Author InformationReprint requests: James F. George, PhD, Division of Cardiothoracic Surgery, Department of Surgery, Room 790 LHRB, 1530 Third Avenue South, University of Alabama at Birmingham, Birmingham, AL 35294-0007. Telephone: 205-934-4261. Fax: 205-975-0085
    • ,
  • Salpy V. Pamboukian, MD, MSPH

      Affiliations

    • Division of Cardiovascular Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • José A. Tallaj, MD

      Affiliations

    • Division of Cardiovascular Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • David C. Naftel, PhD

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • Susan L. Myers, BBA, QMIS

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • Margaret T. Foushee, MPH

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • Robert N. Brown, BS

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • Octavio E. Pajaro, MD, PhD

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • David C. McGiffin, MD

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • James K. Kirklin, MD

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama

References 

  1. Costanzo MR, Naftel DC, Pritzker MR, et al. Heart transplant coronary artery disease detected by coronary angiography: a multiinstitutional study of preoperative donor and recipient risk factors. J Heart Lung Transplant. 1998;17:744–753
  2. Morrow WR, Naftel D, Chinnock R, et al. Outcome of listing for heart transplantation in infants younger than six months: predictors of death and interval to transplantation. J Heart Lung Transplant. 1997;16:1255–1266
  3. Schowengerdt KO, Naftel DC, Seib PM, et al. Infection after pediatric heart transplantation: results of a multiinstitutional study. J Heart Lung Transplant. 1997;16:1207–1216
  4. Mills RM, Naftel DC, Kirklin JK, et al. Heart transplant rejection with hemodynamic compromise: a multiinstitutional study of the role of endomyocardial cellular infiltrate. J Heart Lung Transplant. 1997;16:813–821
  5. Smart FW, Naftel DC, Costanzo MR, et al. Risk factors for early, cumulative, and fatal infections after heart transplantation: a multiinstitutional study. J Heart Lung Transplant. 1996;15:329–341
  6. De Maria R, Minoli L, Parolini M, et al. Prognostic determinants of six-month morbidity and mortality in heart transplant recipients. J Heart Lung Transplant. 1996;15:124–135
  7. Kubo SH, Naftel DC, Mills RM, et al. Risk factors for late recurrent rejection after heart transplantation: a multiinstitutional, multivariable analysis. J Heart Lung Transplant. 1995;14:409–418
  8. Jarcho J, Naftel DC, Shroyer TW, et al. Influence of HLA mismatch on rejection after heart transplantation: a multiinstitutional study. J Heart Lung Transplant. 1994;13:583–595
  9. Kirklin JK, Naftel DC, Levine TB, et al. Cytomegalovirus after heart transplantation (Risk factors for infection and death: a multiinstitutional study). J Heart Lung Transplant. 1994;13:394–404
  10. Miller LW, Naftel DC, Bourge RC, et al. Infection after heart transplantation: a multiinstitutional study. J Heart Lung Transplant. 1994;13:381–392
  11. Bourge RC, Naftel DC, Costanzo-Nordin MR, et al. Pretransplantation risk factors for death after heart transplantation: a multiinstitutional study. J Heart Lung Transplant. 1993;12:549–562
  12. Kobashigawa JA, Kirklin JK, Naftel DC, et al. Pretransplantation risk factors for acute rejection after heart transplantation: a multiinstitutional study. J Heart Lung Transplant. 1993;12:355–366
  13. Ibrahim JE, Sweet SC, Flippin M, et al. Rejection is reduced in thoracic organ recipients when transplanted in the first year of life. J Heart Lung Transplant. 2002;21:311–318
  14. Webber SA, Naftel DC, Parker J, et al. Late rejection episodes more than 1 year after pediatric heart transplantation: risk factors and outcomes. J Heart Lung Transplant. 2003;22:869–875
  15. Demers P, Moffatt S, Oyer PE, et al. Long-term results of heart transplantation in patients older than 60 years. J Thorac Cardiovasc Surg. 2003;126:224–231
  16. Kulikowska A, Boslaugh SE, Huddleston CB, et al. Infectious, malignant, and autoimmune complications in pediatric heart transplant recipients. J Pediatr. 2008;152:671–677
  17. Marelli D, Laks H, Kobashigawa JA, et al. Seventeen-year experience with 1,083 heart transplants at a single institution. Ann Thorac Surg. 2002;74:1558–1566
  18. Blackstone EH, Naftel DC, Turner ME. The decomposition of time-varying hazard into phases, each incorporating a separate stream of concomitant information. J Am Stat Assoc. 1986;81:615–624
  19. Scalera NM, Mossad SB. The first pandemic of the 21st century: a review of the 2009 pandemic variant influenza A (H1N1) virus. Postgrad Med. 2009;121:43–47
  20. Luk J, Gross P, Thompson WW. Observations on mortality during the 1918 influenza pandemic. Clin Infect Dis. 2001;33:1375–1378
  21. Blanche C, Blanche DA, Kearney B, et al. Heart transplantation in patients seventy years of age and older: a comparative analysis of outcome. J Thorac Cardiovasc Surg. 2001;121:532–541
  22. Borkon AM, Muehlebach GF, Jones PG, et al. An analysis of the effect of age on survival after heart transplant. J Heart Lung Transplant. 1999;18:668–674
  23. Marelli D, Kobashigawa J, Hamilton MA, et al. Long-term outcomes of heart transplantation in older recipients. J Heart Lung Transplant. 2008;27:830–834
  24. Tjang YS, Blanz U, Hornik L, et al. Heart transplantation in children: clinical outcomes in a single center. Ann Thorac Surg. 2007;84:1640–1644
  25. Tjang YS, van der Heijden GJ, Tenderich G, et al. Impact of recipient's age on heart transplantation outcome. Ann Thorac Surg. 2008;85:2051–2055
  26. Weiss ES, Nwakanma LU, Patel ND, et al. Outcomes in patients older than 60 years of age undergoing orthotopic heart transplantation: an analysis of the UNOS database. J Heart Lung Transplant. 2008;27:184–191

PII: S1053-2498(10)00284-6

doi: 10.1016/j.healun.2010.05.003

The Journal of Heart and Lung Transplantation
Volume 29, Issue 9 , Pages 966-972 , September 2010

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