The Journal of Heart and Lung Transplantation
Volume 29, Issue 9 , Pages 966-972 , September 2010

Balancing rejection and infection with respect to age, race, and gender: Clues acquired from 17 years of cardiac transplantation data

  • James F. George, PhD

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    • Corresponding Author InformationReprint requests: James F. George, PhD, Division of Cardiothoracic Surgery, Department of Surgery, Room 790 LHRB, 1530 Third Avenue South, University of Alabama at Birmingham, Birmingham, AL 35294-0007. Telephone: 205-934-4261. Fax: 205-975-0085
    • ,
  • Salpy V. Pamboukian, MD, MSPH

      Affiliations

    • Division of Cardiovascular Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • José A. Tallaj, MD

      Affiliations

    • Division of Cardiovascular Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • David C. Naftel, PhD

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • Susan L. Myers, BBA, QMIS

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • Margaret T. Foushee, MPH

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • Robert N. Brown, BS

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • Octavio E. Pajaro, MD, PhD

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • David C. McGiffin, MD

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    • ,
  • James K. Kirklin, MD

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama

  • Image Result

    Cumulative incidence of rejection in recipients stratified by immunosuppression era. The circles represent non-parametric estimates of cumulative rejection episodes. Vertical bars represent the 70% co

    Cumulative incidence of rejection in recipients stratified by immunosuppression era. The circles represent non-parametric estimates of cumulative rejection episodes. Vertical bars represent the 70% confidence limits of the non-parametric estimate. The solid line is a parametric estimate resulting from the statistical model of cumulative rejection episodes. The dotted lines represent the 70% confidence limits of the parametric estimate.

  • Image Result
    Cumulative incidence of infection in recipients stratified by immunosuppression era. The circles represent non-parametric estimates of cumulative rejection episodes. Vertical bars represent the 70% co

    Cumulative incidence of infection in recipients stratified by immunosuppression era. The circles represent non-parametric estimates of cumulative rejection episodes. Vertical bars represent the 70% confidence limits of the non-parametric estimate.

  • Image Result
    Cumulative incidence of rejection in recipients stratified by race and gender. The circles represent nonparametric estimates of cumulative rejection episodes. Vertical bars represent the 70% confidenc

    Cumulative incidence of rejection in recipients stratified by race and gender. The circles represent nonparametric estimates of cumulative rejection episodes. Vertical bars represent the 70% confidence limits of the non-parametric estimate.

  • Image Result
    Cumulative incidence of infection in recipients stratified by race and gender. The circles represent non-parametric estimates of cumulative rejection episodes. Vertical bars represent the 70% confiden

    Cumulative incidence of infection in recipients stratified by race and gender. The circles represent non-parametric estimates of cumulative rejection episodes. Vertical bars represent the 70% confidence limits of the non-parametric estimate.

  • Image Result
    Cumulative incidence of rejection in recipients stratified by age at the time of transplantation. The circles represent non-parametric estimates of cumulative rejection episodes. Vertical bars represe

    Cumulative incidence of rejection in recipients stratified by age at the time of transplantation. The circles represent non-parametric estimates of cumulative rejection episodes. Vertical bars represent the 70% confidence limits of the non-parametric estimate.

  • Image Result
    Cumulative incidence of infection in recipients stratified by age at the time of transplantation. The circles represent non-parametric estimates of cumulative rejection episodes. Vertical bars represe

    Cumulative incidence of infection in recipients stratified by age at the time of transplantation. The circles represent non-parametric estimates of cumulative rejection episodes. Vertical bars represent the 70% confidence limits of the non-parametric estimate.

  • Image Result
    The solution of multivariate equations depicting cumulative episodes of rejection or infection with respect to age at the time of transplantation in: (a) white recipients at 1 year post-transplantatio

    The solution of multivariate equations depicting cumulative episodes of rejection or infection with respect to age at the time of transplantation in: (a) white recipients at 1 year post-transplantation, transplanted in 1994; (b) white recipients at 1 year post-transplantation, transplanted in 2004; and (c) white recipients at 5 years post-transplantation, transplanted in 2004. The dashed lines represent the 70% confidence intervals.

  • Image Result
    Depictions of the proportion of patients dying from rejection or infection with respect to age at the time of transplantation at (a) 1 year or (b) 5 years post-transplantation.

    Depictions of the proportion of patients dying from rejection or infection with respect to age at the time of transplantation at (a) 1 year or (b) 5 years post-transplantation.

PII: S1053-2498(10)00284-6

doi: 10.1016/j.healun.2010.05.003

The Journal of Heart and Lung Transplantation
Volume 29, Issue 9 , Pages 966-972 , September 2010

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