The Journal of Heart and Lung Transplantation
Volume 29, Issue 8 , Pages 912-913 , August 2010

Rat Model in the Study of the Role of α-Gal in Heart Valve Bioprostheses Calcification

  • Nermine Lila, DVM, PhD

      Affiliations

    • The University Paris Descartes, Laboratory of Biosurgical Researches, Georges Pompidou Hospital, Paris, France
    • ,
  • Christopher G.A. McGregor, MD, PhD

      Affiliations

    • William J. von Liebig Transplant Center, Mayo Clinic, Rochester, Minnesota
    • ,
  • Guerard W. Byrne, PhD

      Affiliations

    • William J. von Liebig Transplant Center, Mayo Clinic, Rochester, Minnesota
    • ,
  • Alain Carpentier, MD, PhD

      Affiliations

    • The University Paris Descartes, Laboratory of Biosurgical Researches, Assistance Publique Hôpitaux de Paris, Department of Cardiovascular Surgery and Organ Transplantation, Georges Pompidou Hospital, Paris, France

References 

  1. Konakci KZ, Bohle B, Blumer R, et al. Alpha-gal on bioprostheses: xenograft immune response in cardiac surgery. Eur J Clin Invest. 2005;35:17–23
  2. Sharma A, Naziruddin B, Cui C, et al. Pig cells that lack the gene for alpha1-3 galactosyltransferase express low levels of the gal antigen. Transplantation. 2003;75:430–436
  3. Human P, Zilla P. Characterization of the immune response to valve bioprostheses and its role in primary tissue failure. Ann Thorac Surg. 2001;71:S385–S388
  4. Carpentier A, Nashef A, Carpentier S, Ahmed A, Goussef N. Techniques for prevention of calcification of valvular bioprostheses. Circulation. 1984;70:I165–I168
  5. Carpentier SM, Carpentier A, Chen L, Shen M, Quintero LJ, Witzel TH. Calcium mitigation in bioprosthetic tissues by iron pretreatment: the challenge of iron leaching. Ann Thorac Surg. 1995;60(2 suppl):S332–S338

PII: S1053-2498(10)00277-9

doi: 10.1016/j.healun.2010.04.020

The Journal of Heart and Lung Transplantation
Volume 29, Issue 8 , Pages 912-913 , August 2010

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