The Journal of Heart and Lung Transplantation
Volume 29, Issue 9 , Pages 1009-1013 , September 2010

Supratherapeutic anticoagulation from low-molecular-weight heparin in lung transplant recipients

  • Jonathan P. Singer, MD, MS

      Affiliations

    • Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California
    • Corresponding Author InformationReprint requests: Jonathan P. Singer, MD, MS, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, Box 0111, M1097, 505 Parnassus Avenue, San Francisco, CA 94143. Telephone: 415-476-6030. Fax: 415-476-5712
    • ,
  • Meng-Yu Huang, PharmD

      Affiliations

    • Department of Clinical Pharmacy, University of California, San Francisco, San Francisco, California
    • ,
  • Christine Hui, PharmD

      Affiliations

    • Department of Clinical Pharmacy, University of California, San Francisco, San Francisco, California
    • ,
  • Paul D. Blanc, MD, MPH

      Affiliations

    • Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California
    • ,
  • Rebecca F. Boettger, PharmD

      Affiliations

    • Department of Clinical Pharmacy, University of California, San Francisco, San Francisco, California
    • ,
  • Jeffery Golden, MD

      Affiliations

    • Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California
    • ,
  • Katherine Watkins, PharmD

      Affiliations

    • Department of Clinical Pharmacy, University of California, San Francisco, San Francisco, California
    • ,
  • Charles Hoopes, MD

      Affiliations

    • Division of Cardiothoracic Surgery, Department of Surgery, University of California, San Francisco, San Francisco, California
    • ,
  • Lorriana E. Leard, MD

      Affiliations

    • Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California

References 

  1. Burns KE, Iacono AT. Pulmonary embolism on postmortem examination: an under-recognized complication in lung-transplant recipients?. Transplantation. 2004;77:692–698
  2. Izbicki G, Bairey O, Shitrit D, et al. Increased thromboembolic events after lung transplantation. Chest. 2006;129:412–416
  3. Kahan ES, Petersen G, Gaughan JP, et al. High incidence of venous thromboembolic events in lung transplant recipients. J Heart Lung Transplant. 2007;26:339–344
  4. Kroshus TJ, Kshettry VR, Hertz MI, et al. Deep venous thrombosis and pulmonary embolism after lung transplantation. J Thorac Cardiovasc Surg. 1995;110:540–544
  5. Nathan SD, Barnett SD, Urban BA, et al. Pulmonary embolism in idiopathic pulmonary fibrosis transplant recipients. Chest. 2003;123:1758–1763
  6. Kearon C, Kahn SR, Agnelli G, et al. Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest. 2008;133(suppl):454S–545S
  7. Bazinet A, Almanric K, Brunet C, et al. Dosage of enoxaparin among obese and renal impairment patients. Thromb Res. 2005;116:41–50
  8. Friedrich E, Hameed AB. Fluctuations in anti-factor Xa levels with therapeutic enoxaparin anticoagulation in pregnancy. J Perinatol. 2010;30:253–257
  9. Levine MN, Planes A, Hirsh J, et al. The relationship between anti-factor Xa level and clinical outcome in patients receiving enoxaparine low molecular weight heparin to prevent deep vein thrombosis after hip replacement. Thromb Haemost. 1989;62:940–944
  10. Bara L, Leizorovicz A, Picolet H, et al. Correlation between anti-Xa and occurrence of thrombosis and haemorrhage in post-surgical patients treated with either logiparin (LMWH) or unfractionated heparin. Thromb Res. 1992;65:641–650
  11. Samama MM, Poller L. Contemporary laboratory monitoring of low molecular weight heparins. Clin Lab Med. 1995;15:119–123
  12. Baran DA, Galin ID, Gass AL. Calcineurin inhibitor-associated early renal insufficiency in cardiac transplant recipients: risk factors and strategies for prevention and treatment. Am J Cardiovasc Drugs. 2004;4:21–29
  13. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16:31–41
  14. Hirsh J, Levine MN. Low molecular weight heparin. Blood. 1992;79:1–17
  15. Hirsh J, Bauer KA, Donati MB, et al. Parenteral anticoagulants: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest. 2008;133(suppl):141S–159S
  16. Yegen HA, Lederer DJ, Barr RG, et al. Risk factors for venous thromboembolism after lung transplantation. Chest. 2007;132:547–553

PII: S1053-2498(10)00275-5

doi: 10.1016/j.healun.2010.04.018

The Journal of Heart and Lung Transplantation
Volume 29, Issue 9 , Pages 1009-1013 , September 2010

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