The Journal of Heart and Lung Transplantation
Volume 29, Issue 6 , Pages 599-602 , June 2010

Gene expression profiling and cardiac allograft rejection monitoring: Is IMAGE just a mirage?

  • Mandeep R. Mehra, MD

      Affiliations

    • University of Maryland School of Medicine, Baltimore, Maryland
    • Corresponding Author InformationReprint requests: Mandeep R. Mehra, MD, University of Maryland Medical Center, 22 S Greene St, Rm S3B06, Baltimore, MD 21201. Telephone: 410-328-2056. Fax: 410-328-4382
    • ,
  • Jayan Parameshwar, MD

      Affiliations

    • Papworth Hospital, Papworth Everard, Cambridge, United Kingdom

References 

  1. Starling RC, Pham M, Valantine H, Miller L, et al. Working Group on Molecular Testing in Cardiac Transplantation Molecular testing in the management of cardiac transplant recipients: initial clinical experience. J Heart Lung Transplant. 2006;25:1389–1395
  2. Mehra MR, Kobashigawa JA, Deng MC, et al. CARGO Investigators Transcriptional signals of T-cell and corticosteroid-sensitive genes are associated with future acute cellular rejection in cardiac allografts. J Heart Lung Transplant. 2007;26:1255–1263
  3. Mehra MR, Kobashigawa JA, Deng MC, et al. CARGO Investigators Clinical implications and longitudinal alteration of peripheral blood transcriptional signals indicative of future cardiac allograft rejection. J Heart Lung Transplant. 2008;27:297–301
  4. Pham MX, Teuteberg JJ, Kfoury AG, et al. Gene-expression profiling for rejection surveillance after cardiac transplantation. N Engl J Med. 2010;[online: doi: 10.1056/NEJMoa0912965]
  5. Hamour IM, Burke MM, Bell AD, Panicker MG, Banerjee R, Banner NR. Limited utility of endomyocardial biopsy in the first year after heart transplantation. Transplantation. 2008;85:969–974
  6. Klingenberg R, Koch A, Schnabel PA, et al. Allograft rejection of ISHLT grade ≥3A occurring late after heart transplantation—a distinct entity?. J Heart Lung Transplant. 2003;22:1005–1013
  7. Pham MX, Deng MC, Kfoury AG, Teuteberg JJ, Starling RC, Valantine H. Molecular testing for long-term rejection surveillance in heart transplant recipients: design of the Invasive Monitoring Attenuation Through Gene Expression (IMAGE) trial. J Heart Lung Transplant. 2007;26:808–814
  8. Kfoury AG, Hammond ME. Controversies in defining cardiac antibody-mediated rejection: need for updated criteria. J Heart Lung Transplant. 2010;29:389–394
  9. Gupta S, Mitchell JD, Lavingia B, et al. Utility of routine immunofluorescence staining for C4d in cardiac transplant recipients. J Heart Lung Transplant. 2009;28:776–780
  10. Fedson SE, Daniel SS, Husain AN. Immunohistochemistry staining of C4d to diagnose antibody-mediated rejection in cardiac transplantation. J Heart Lung Transplant. 2008;27:372–379
  11. Kaul S, Diamond GA. Good enough: a primer on the analysis and interpretation of noninferiority trials. Ann Intern Med. 2006;145:62–69
  12. Estep JD, Shah DJ, Nagueh SF, Mahmarian JJ, Torre-Amione G, Zoghbi WA. The role of multimodality cardiac imaging in the transplanted heart. JACC Cardiovasc Imaging. 2009;2:1126–1140

PII: S1053-2498(10)00266-4

doi: 10.1016/j.healun.2010.04.010

The Journal of Heart and Lung Transplantation
Volume 29, Issue 6 , Pages 599-602 , June 2010

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