The Journal of Heart and Lung Transplantation
Volume 29, Issue 8 , Pages 838-840 , August 2010

Pig heart xenotransplantation as a bridge to allotransplantation

  • David K.C. Cooper, MD, PhD, FRCS

      Affiliations

    • Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
    • Corresponding Author InformationReprint requests: David K. C. Cooper, MD, PhD, FRCS, University of Pittsburgh Medical Center, Massachusetts General Hospital, Starzl Biomedical Sciences Tower, 200 Lothrop St, Rm W1543, Pittsburgh, PA 15261. Telephone: 412-383-6961. Fax: 412-624-1172
    • ,
  • Jeffrey J. Teuteberg, MD

      Affiliations

    • Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

References 

  1. Cooper DKC, Keogh A, Brink J, et al. Report of the Xenotransplantation Advisory Committee of the International Society for Heart and Lung Transplantation: the present status of xenotransplantation and its potential role in the treatment of end-stage cardiac and pulmonary diseases. J Heart Lung Transplant. 2000;19:1125–1165
  2. Kirklin JK, Naftel DC, Kormos RL, et al. Second INTERMACS annual report: More than 1,000 primary left ventricular assist device implants. J Heart Lung Transplant. 2010;29:1–10
  3. Pagani FD, Miller LW, Russell SD, et al. Extended mechanical circulatory support with a continuous-flow rotary left ventricular assist device. J Am Coll Cardiol. 2009;54:312–321
  4. Buhler L, Basker M, Alwayn IPJ, et al. Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates. Transplantation. 2000;70:1323–1331
  5. Lin CC, Cooper DKC, Dorling A. Coagulation dysregulation as a barrier to xenotransplantation in the primate. Transpl Immunol. 2009;21:75–80
  6. Teotia SS, Walker RC, Schirmer JM, et al. Prevention, detection, and management of early bacterial and fungal infections in a preclinical cardiac xenotransplantation model that achieves prolonged survival. Xenotransplantation. 2005;12:127–133
  7. Rose EA, Gelijns AC, Moskowitz AJ, et al. Long-term mechanical left ventricular assistance for end-stage heart failure. N Engl J Med. 2001;345:1435–1443
  8. Gronda E, Bourge RC, Costanzo MR, et al. Heart rhythm considerations in heart transplant candidates and considerations for ventricular assist devices: International Society for Heart and Lung Transplantation guidelines for the care of cardiac transplant candidates—2006. J Heart Lung Transplant. 2006;25:1043–1056
  9. Centers for Medicaid & Medicare Services. Medicare national coverage determination manual: chapter 1, part 1 (sections 10-80.12): coverage determination. Baltimore, MD: Centers for Medicaid & Medicare Services; 2008;
  10. Wilson SR, Mudge GH, Stewart GC, Givertz MM. Evaluation for a ventricular assist device selecting the appropriate candidate. Ciorculation. 2009;119:2225–2232
  11. Cooper DKC, Tseng Y-L, Saidman SL. Allo- and xeno-antibody cross-reactivity in transplantation. Transplantation. 2004;77:1–5
  12. Ekser B, Gridelli B, Tector AJ, Cooper DKC. Pig liver xenotransplantation as a bridge to allotransplantation in acute liver failure: which patients might benefit?. Transplantation. 2009;88:1041–1049
  13. West LJ, Pollock-Barziv SM, Dipchand AI, et al. ABO-incompatible heart transplantation in infants. N Engl J Med. 2001;344:793–800
  14. Fan X, Ang A, Pollock-Barziv SM, et al. Donor-specific B-cell tolerance after ABO-incompatible infant heart transplantation. Nat Med. 2004;10:1227–1233
  15. Rood PPM, Tai H-C, Hara H, et al. Late onset of development of natural anti-nonGal antibodies in infant humans and baboons: implications for xenotransplantation in infants. Transplant Int. 2007;20:1050–1058
  16. Kuwaki K, Tseng Y-L, Dor FJMF, et al. Heart transplantation in baboons using α1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med. 2005;11:29–31
  17. Tseng Y-L, Kuwaki K, Dor FJMF, et al. α 1,3-galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching six months. Transplantation. 2005;80:1493–1500
  18. Mohiuddin MM, Singh AK, Corcoran PC, et al. B cell depletion of anti-CD20 prolongs GalKO.hCD46 pig heterotopic cardiac xenograft survival in baboons. (Abstract IXA-O-2.5) Xenotransplantation. 2009;16:357
  19. Vial CM, Ostlie DJ, Bhatti FN, et al. Life supporting function for over one month of a transgenic porcine heart in a baboon. J Heart Lung Transplant. 2000;19:224–229
  20. McGregor CGA, Byrne GW, Vlasin M, et al. Early cardiac function and gene expression after orthotopic cardiac xenotransplantation. (Abstract IXA-O-2.4) Xenotransplantation. 2009;16:356

PII: S1053-2498(10)00233-0

doi: 10.1016/j.healun.2010.03.017

The Journal of Heart and Lung Transplantation
Volume 29, Issue 8 , Pages 838-840 , August 2010

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