The Journal of Heart and Lung Transplantation
Volume 29, Issue 6 , Pages 616-624 , June 2010

Post-operative heparin may not be required for transitioning patients with a HeartMate II left ventricular assist system to long-term warfarin therapy

  • Mark S. Slaughter, MD

      Affiliations

    • Division of Thoracic and Cardiovascular Surgery, University of Louisville, Louisville, Kentucky
    • Corresponding Author InformationReprint requests: Mark S. Slaughter, MD, University of Louisville, 201 Abraham Flexner Way, Suite 1200, Louisville, KY 40202. Telephone: 502-561-2180. Fax: 502-561-2190
    • ,
  • Yoshifumi Naka, MD

      Affiliations

    • Department of Surgery and the Cardiac Transplantation and Mechanical Circulatory Support Programs, Columbia University, New York, New York
    • ,
  • Ranjit John, MD

      Affiliations

    • Division of Cardiothoracic Surgery, University of Minnesota, Minneapolis, Minnesota
    • ,
  • Andrew Boyle, MD

      Affiliations

    • Division of Cardiology, University of Minnesota, Minneapolis, Minnesota
    • ,
  • John V. Conte, MD

      Affiliations

    • Division of Surgery, Johns Hopkins University, Baltimore, Maryland
    • ,
  • Stuart D. Russell, MD

      Affiliations

    • Division of Cardiology and the Heart Failure and Transplantation Program, Johns Hopkins University, Baltimore, Maryland
    • ,
  • Keith D. Aaronson, MD

      Affiliations

    • Department of Internal Medicine and the Heart Failure Program, University of Michigan, Ann Arbor, Michigan
    • ,
  • Kartik S. Sundareswaran, PhD

      Affiliations

    • Thoratec Corporation, Pleasanton, California
    • ,
  • David J. Farrar, PhD

      Affiliations

    • Thoratec Corporation, Pleasanton, California
    • ,
  • Francis D. Pagani, MD, PhD

      Affiliations

    • Section of Cardiac Surgery, University of Michigan, Ann Arbor, Michigan

References 

  1. Rose EA, Gelijns AC, Moskowitz AJ, et al. Long-term mechanical left ventricular assistance for end-stage heart failure. N Engl J Med. 2001;345:1435–1443
  2. Frazier OH, Rose EA, Oz MC, et al. Multicenter clinical evaluation of the HeartMate vented electric left ventricular assist system in patients awaiting heart transplantation. J Thorac Cardiovasc Surg. 2001;122:1186–1195
  3. Miller LW, Pagani FD, Russell SD, et al. Use of a continuous-flow device in patients awaiting heart transplantation. N Engl J Med. 2007;357:885–896
  4. Pagani FD, Miller LW, Russell SD, et al. Extended mechanical circulatory support with a continuous-flow rotary left ventricular assist device. J Am Coll Cardiol. 2009;54:312–321
  5. Slaughter MS, Rogers JG, Milano CA, et al. Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med. 2009;361:2241–2251
  6. John R, Kamdar F, Liao K, et al. Low thromboembolic risk for patients with the HeartMate II left ventricular assist device. J Thorac Cardiovasc Surg. 2008;136:1318–1323
  7. Boyle AJ, Russell SD, Teuteberg JJ, et al. Low thromboembolism and pump thrombosis with the HeartMate II left ventricular assist device: analysis of outpatient anti-coagulation. J Heart Lung Transplant. 2009;28:881–887
  8. Lahpor J, Khaghani A, Hetzer R, et al. European results with a continuous-flow ventricular assist device for advanced heart-failure patients. Eur J Cardiothorac Surg (in press).
  9. Struber M, Sander K, Lahpor J, et al. HeartMate II left ventricular assist device; early European experience. Eur J Cardiothorac Surg. 2008;34:289–294
  10. Griffith BP, Kormos RL, Borovetz HS, et al. HeartMate II left ventricular assist system: from concept to first clinical use. Ann Thorac Surg. 2001;71(suppl):S116–S120
  11. Maher TR, Butler KC, Poirier VL, et al. HeartMate left ventricular assist devices: a multigeneration of implanted blood pumps. Artif Organs. 2001;25:422–426
  12. Kirklin JK, Naftel DC, Stevenson LW, et al. INTERMACS database for durable devices for circulatory support: first annual report. J Heart Lung Transplant. 2008;27:1065–1072
  13. Kaplon RJ, Gillinov AM, Smedira NG, et al. Vitamin K reduces bleeding in left ventricular assist device recipients. J Heart Lung Transplant. 1999;18:346–350
  14. Livingston ER, Fisher CA, Bibidakis EJ, et al. Increased activation of the coagulation and fibrinolytic systems leads to hemorrhagic complications during left ventricular assist implantation. Circulation. 1996;94:II-227–II-234
  15. Slaughter MS, Sobieski MA, Gallagher C, et al. Fibrinolytic activation during long-term support with the HeartMate II left ventricular assist device. ASAIO J. 2008;54:115–119
  16. Geisen U, Heilmann C, Beyersdorf F, et al. Non-surgical bleeding in patients with ventricular assist devices could be explained by acquired von Willebrand disease. Eur J Cardiothorac Surg. 2008;33:679–684
  17. Klovaite J, Gustafsson F, Mortensen SA, et al. Severely impaired von Willebrand factor-dependent platelet aggregation in patients with a continuous-flow left ventricular assist device (HeartMate II). J Am Coll Cardiol. 2009;53:2162–2167

PII: S1053-2498(10)00074-4

doi: 10.1016/j.healun.2010.02.003

The Journal of Heart and Lung Transplantation
Volume 29, Issue 6 , Pages 616-624 , June 2010

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