The Journal of Heart and Lung Transplantation
Volume 29, Issue 6 , Pages 672-679 , June 2010

Cardiac fibrosis and cellular hypertrophy decrease the degree of reverse remodeling and improvement in cardiac function during left ventricular assist

References 

  1. Deng MC, Edwards LB, Hertz MI, et al. Mechanical circulatory support device database of the International Society for Heart and Lung Transplantation: third annual report—2005. J Heart Lung Transplant. 2005;24:1182–1187
  2. Mancini DM, Beniaminovitz A, Levin H, et al. Low incidence of myocardial recovery after left ventricular assist device implantation in patients with chronic heart failure. Circulation. 1998;98:2383–2389
  3. Yacoub MH. A novel strategy to maximize the efficacy of left ventricular assist devices as a bridge to recovery. Eur Heart J. 2001;22:534–540
  4. Matsumiya G, Monta O, Fukushima N, et al. Who would be a candidate for bridge to recovery during prolonged mechanical left ventricular support in idiopathic dilated cardiomyopathy?. J Thorac Cardiovasc Surg. 2005;130:699–705
  5. Dipla K, Mattiello JA, Jeevanandum V, Houser SR, Margulies KB. Myocyte recovery after mechanical circulatory support in humans with end-stage heart failure. Circulation. 1998;97:2316–2322
  6. Levin HR, Oz MC, Chen JM, Packer M, Rose EA, Burkhoff D. Reversal of chronic ventricular dilation in patients with end-stage cardiomyopathy by prolonged mechanical unloading. Circulation. 1995;91:2717–2720
  7. Barbone A, Holmes JW, Heerdt PM, et al. Comparison of right and left ventricular responses to left ventricular assist device support in patients with severe heart failure: a primary role of mechanical unloading underlying reverse remodeling. Circulation. 2001;104:670–675
  8. Klotz S, Foronjy RF, Dickstein ML, et al. Mechanical unloading during left ventricular assist device support increases left ventricular collagen cross-linking and myocardial stiffness. Circulation. 2005;112:364–374
  9. Li YY, Feng Y, McTierman CF, et al. Downregulation of matrix metalloproteinases and reduction in collagen damage in the failing human heart after support with left ventricular assist devices. Circulation. 2001;104:1147–1152
  10. Heerdt PM, Holmes JW, Cai B, et al. Chronic unloading by left ventricular assist device reverses contractile dysfunction and alters gene expression in end-stage heart failure. Circulation. 2000;102:2713–2719
  11. Müller J, Wallukat G, Weng Y-G, et al. Weaning from mechanical cardiac support in patients with idiopathic dilated cardiomyopathy. Circulation. 1997;96:542–549
  12. Hetzer R, Müller J, Weng Y-G, Loebe M, Wallukat G. Midterm follow-up of patients who underwent removal of left ventricular assist device after cardiac recovery from end-stage dilated cardiomyopathy. J Thorac Cardiovasc Surg. 2000;120:843–855
  13. Dandel M, Weng Y, Siniawski H, Potapov E, Lehmkuhl HB, Hetzer R. Long-term results in patients with idiopathic dilated cardiomyopathy after weaning from left ventricular assist devices. Circulation. 2005;112(suppl I):37–45
  14. Brisk EJ, Tansley PD, Hardy J, et al. Left ventricular assist device and drug therapy for the reversal of heart failure. N Engl J Med. 2006;355:1873–1884
  15. Khan T, Okerberg K, Hernandez A, et al. Assessment of myocardial recovery using dobutamine stress echocardiography in LVAD patients. J Heart Lung Transplant. 2001;20:202–203
  16. Marian AJ. Pathogenesis of diverse clinical and pathological phenotypes in hypertrophic cardiomyopathy. Lancet. 2000;355:58–60
  17. Zile MR, Koide M, Sato H, et al. Role of microtubules in the contractile dysfunction of hypertrophied myocardium. J Am Coll Cardiol. 1999;33:250–260
  18. Bruckner BA, Razeghi P, Stetson SJ, et al. Degree of cardiac fibrosis and hypertrophy at time of implantation predicts myocardial improvement during left ventricular assist device support. J Heart Lung Transplant. 2004;23:36–42
  19. Anderson KR, Sutton MG, Lie JT. Histopathological types of cardiac fibrosis in myocardial disease. J Pathol. 1979;128:79–85
  20. Sen S, Bumpus FM. Collagen synthesis in development and reversal of cardiac hypertrophy in spontaneously hypertensive rats. Am J Cardiol. 1979;44:954–963
  21. Moore GW, Hutchins GM, Bulkley BH, Tseng JS, Ki PF. Constituents of the human ventricular myocardium (Connective tissue hyperplasia accompanying muscular hypertrophy). Am Heart J. 1980;100:610–616
  22. Wikman-Coffelt J, Parmley WW, Mason DT. The cardiac hypertrophy process (Analyses of factors determining pathological vs. physiological development). Circ Res. 1979;45:697–706
  23. Kalsi KK, Smolenski RT, Pritchard RD, Khaghani A, Seymour AM, Yacoub MH. Energetics and function of the failing human heart with dilated or hypertrophic cardiomyopathy. Eur J Clin Invest. 1999;29:469–477
  24. Maybaum S, Mancini D, Xydas S, et al. Cardiac improvement during mechanical circulatory support (A prospective multicenter study of the LVAD working group). Circulation. 2007;115:2497–2505

PII: S1053-2498(10)00039-2

doi: 10.1016/j.healun.2010.01.007

The Journal of Heart and Lung Transplantation
Volume 29, Issue 6 , Pages 672-679 , June 2010

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