The Journal of Heart and Lung Transplantation
Volume 29, Issue 6 , Pages 633-640 , June 2010

Natural course and risk factors for impaired renal function during the first year after heart transplantation

  • Janne J. Jokinen, MD, PhD

      Affiliations

    • Department of Cardiothoracic Surgery, Helsinki University Hospital, Helsinki, Finland
    • Cardiopulmonary Research Group, Transplantation Laboratory, University of Helsinki, Helsinki, Finland
    • Corresponding Author InformationReprint requests: Janne J. Jokinen, MD, PhD, Department of Cardiothoracic Surgery, Helsinki University Hospital, P.O. Box 340, Helsinki FI-00029, Finland. Telephone: +358-50-554-8103. Fax: +358-9-471-74475
    • ,
  • Jussi Tikkanen, MD, PhD

      Affiliations

    • Cardiopulmonary Research Group, Transplantation Laboratory, University of Helsinki, Helsinki, Finland
    • Division of Respiratory Diseases, Department of Medicine, Helsinki University Hospital, Helsinki, Finland
    • ,
  • Sinikka Kukkonen, MD, PhD

      Affiliations

    • Department of Anesthesiology, Helsinki University Hospital, Helsinki, Finland
    • ,
  • Pekka Hämmäinen, MD, PhD

      Affiliations

    • Department of Cardiothoracic Surgery, Helsinki University Hospital, Helsinki, Finland
    • ,
  • Jyri Lommi, MD, PhD

      Affiliations

    • Division of Cardiology, Department of Medicine, Helsinki University Hospital, Helsinki, Finland
    • ,
  • Jorma Sipponen, MD, PhD

      Affiliations

    • Department of Cardiothoracic Surgery, Helsinki University Hospital, Helsinki, Finland
    • ,
  • Karl B. Lemström, MD, PhD

      Affiliations

    • Department of Cardiothoracic Surgery, Helsinki University Hospital, Helsinki, Finland
    • Cardiopulmonary Research Group, Transplantation Laboratory, University of Helsinki, Helsinki, Finland

References 

  1. Ozduran V, Yamani MH, Chuang HH, et al. Survival beyond 10 years following heart transplantation: the Cleveland Clinic Foundation experience. Transplant Proc. 2005;37:4509–4512
  2. Trulock EP, Christie JD, Edwards LB, et al. Registry of the International Society for Heart and Lung Transplantation: twenty-fourth official adult lung and heart–lung transplantation report—2007. J Heart Lung Transplant. 2007;26:782–795
  3. Odim J, Wheat J, Laks H, et al. Peri-operative renal function and outcome after orthotopic heart transplantation. J Heart Lung Transplant. 2006;25:162–166
  4. Greenberg A, Thompson ME, Griffith BJ, et al. Cyclosporine nephrotoxicity in cardiac allograft patients—a seven-year follow-up. Transplantation. 1990;50:589–593
  5. Greenberg A, Egel JW, Thompson ME, et al. Early and late forms of cyclosporine nephrotoxicity: studies in cardiac transplant recipients. Am J Kidney Dis. 1987;9:12–22
  6. Ojo AO, Held PJ, Port FK, et al. Chronic renal failure after transplantation of a nonrenal organ. N Engl J Med. 2003;349:931–940
  7. Boyle JM, Moualla S, Arrigain S, et al. Risks and outcomes of acute kidney injury requiring dialysis after cardiac transplantation. Am J Kidney Dis. 2006;48:787–796
  8. Garrido IP, Crespo-Leiro MG, Paniagua MJ, et al. Independent predictors of renal dysfunction after heart transplantation in patients with normal pretransplant renal function. J Heart Lung Transplant. 2005;24:1226–1230
  9. Lindelöw B, Bergh CH, Herlitz H, et al. Predictors and evolution of renal function during 9 years following heart transplantation. J Am Soc Nephrol. 2000;11:951–957
  10. Scandiatransplant database website. http://www.scandiatransplant.org(accessed January 31, 2010)
  11. National Kidney Foundation website. http://www.kidney.org(accessed January 31, 2010)
  12. Traynor J, Mactier R, Geddes CC, et al. How to measure renal function in clinical practice. BMJ. 2006;333:733–737
  13. Levey AS, Coresh J, Balk E, et al. National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med. 2003;139:137–147
  14. Levey AS, Eckardt KU, Tsukamoto Y, et al. Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 2005;67:2089–2100
  15. Levey AS, Bosch JP, Lewis JB, et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Ann Intern Med. 1999;130:461–470
  16. Levey AS, Coresh J, Greene T, et al. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med. 2006;145:247–254
  17. Vossler MR, Ni H, Toy W, et al. Pre-operative renal function predicts development of chronic renal insufficiency after orthotopic heart transplantation. J Heart Lung Transplant. 2002;21:874–881
  18. Satchithananda DK, Parameshwar J, Sharples L, et al. The incidence of end-stage renal failure in 17 years of heart transplantation: a single center experience. J Heart Lung Transplant. 2002;21:651–657
  19. Mann JF, Schmieder RE, McQueen M, et al. Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial. Lancet. 2008;372:547–553
  20. Cantarovich M. Renal protective strategies in heart transplant patients. Curr Opin Cardiol. 2007;22:133–138
  21. Sanchez V, Delgado JF, Morales JM, et al. Chronic cyclosporine-induced nephrotoxiciy in heart transplant patients: long-term benefits of treatment with mycophenolate mofetil and low-dose cyclosporine. Transplant Proc. 2004;36:2823–2825
  22. Sachdeva R, Blaszak RT, Ainley KA, et al. Determinants of renal function in pediatric heart transplant recipients: long-term follow-up study. J Heart Lung Transplant. 2007;26:108–113
  23. Lubitz SA, Pinney S, Wisnivesky JP, et al. Statin therapy associated with a reduced risk of chronic renal failure after cardiac transplantation. J Heart Lung Transplant. 2007;26:264–272
  24. Al Aly Z, Abbas S, Moore E, et al. The natural history of renal function following orthotopic heart transplant. Clin Transplant. 2005;19:683–689

PII: S1053-2498(10)00036-7

doi: 10.1016/j.healun.2010.01.004

The Journal of Heart and Lung Transplantation
Volume 29, Issue 6 , Pages 633-640 , June 2010

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