The Journal of Heart and Lung Transplantation
Volume 29, Issue 4 , Pages 417-423 , April 2010

Deposition of C4d and C3d in cardiac transplants: A factor in the development of coronary artery vasculopathy

  • Ellen L. Moseley, BSc

      Affiliations

    • Department of Pathology, Papworth Hospital NHS Trust, Cambridge, UK
    • Corresponding Author InformationReprint requests: Ellen Moseley, BSc, Department of Pathology, Papworth Hospital NHS Trust, Papworth Everard, Cambridge CB23 3RE, UK. Telephone: 44-1480-364304. Fax: 44-1480-364777
    • ,
  • Carl Atkinson, PhD

      Affiliations

    • Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina
    • ,
  • Linda D. Sharples, PhD

      Affiliations

    • MRC Biostatistics Unit, Cambridge, UK
    • ,
  • John Wallwork, FRCS

      Affiliations

    • Department of Surgery, Papworth Hospital NHS Trust, Cambridge, UK
    • ,
  • Martin J. Goddard, FRCPath

      Affiliations

    • Department of Pathology, Papworth Hospital NHS Trust, Cambridge, UK

References 

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  2. Segovia J. Update on cardiac allograft vasculopathy. Curr Opin Organ Transplant. 2002;7:240–251
  3. Valantine H. Guest Editor's introduction. J Heart Lung Transplant. 2005;24(suppl):S183–S184
  4. Baldwin WM, Flavahan NA, Fairchild RL. Integration of complement and leukocytes in response to allotransplantation. Curr Opin Organ Transplant. 2002;7:92–99
  5. Zweers N, Petersen AH, van der Hoeven J, et al. Donor brain death aggravates chronic rejection after lung transplantation in rats. Transplantation. 2004;78:1251–1258
  6. Chen W, Thorburn C, Miura S, et al. Autoimmune-mediated vasculopathy. Clin Immunol. 2001;100:57–70
  7. Stoica SC, Cafferty F, Pauriah M, et al. The cumulative effect of acute rejection on development of cardiac allograft vasculopathy. J Heart Lung Transplant. 2006;25:420–425
  8. Keogh A. Calcineurin inhibitors in heart transplantation. J Heart Lung Transplant. 2004;23(suppl):S202–S206
  9. Taylor DO, Edwards LB, Boucek MM, et al. Registry of the International Society for Heart and Lung Transplantation: twenty-fourth official adult heart transplant report—2007. J Heart Lung Transplant. 2007;26:769–781
  10. Stewart S, Winters GL, Fishbein MC, et al. Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant. 2005;24:1710–1720
  11. Rodriguez ER, Skojec DV, Tan CD, et al. Antibody-mediated rejection in human cardiac allografts: evaluation of immunoglobulins and complement activation products C4d and C3d as markers. Am J Transplant. 2005;5:2778–2785
  12. Mauiyyedi S, Colvin RB. Humoral rejection in kidney transplantation: new concepts in diagnosis and treatment. Curr Opin Nephrol Hypertens. 2002;11:609–618
  13. Eggertsen G, Nyberg G, Nilsson B, et al. Complement deposition in renal allografts with early malfunction. APMIS. 2001;109:825–834
  14. Crespo M, Pascual M, Tolkoff-Rubin N, et al. Acute humoral rejection in renal allograft recipients: i. Incidence, serology and clinical characteristics. Transplantation. 2001;71:652–658
  15. Baldwin WM, Samaniego-Picota M, Kasper EK, et al. Complement deposition in early cardiac transplant biopsies is associated with ischemic injury and subsequent rejection episodes. Transplantation. 1999;68:894–900
  16. Baldwin WM, Qian Z, Ota H, et al. Complement as a mediator of vascular inflammation and activation in allografts. J Heart Lung Transplant. 2000;19:723–730
  17. Michaels PJ, Espejo ML, Kobashigawa J, et al. Humoral rejection in cardiac transplantation: risk factors, hemodynamic consequences and relationship to transplant coronary artery disease. J Heart Lung Transplant. 2003;22:58–69
  18. Poelzl G, Ullrich R, Huber A, et al. Capillary deposition of the complement fragment C4d in cardiac allograft biopsies is associated with allograft vasculopathy. Transplant Int. 2005;18:313–317
  19. Billingham ME, Cary NR, Hammond ME, et al. A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: heart rejection study group. J Heart Lung Transplant. 1990;9:587–593
  20. Chantrauwat C, Qiao JH, Kobashigawa J, et al. Immunoperoxidase staining for C4d on paraffin-embedded tissue in cardiac allograft endomyocardial biopsies: comparison to frozen tissue immunofluorescence. Appl Immunohistochem Mol Morphol. 2004;12:166–171
  21. Fedson SE, Daniel SS, Husain AN. Imunohistochemistry staining of C4d to diagnose antibody mediated rejection in cardiac transplant. J Heart Lung. 2008;27:372–379
  22. Arumugam TV, Shiels IA, Woodruff TM. The role of the complement system in ischemia-reperfusion injury. Shock. 2004;21:401–409
  23. Regele H, Böhmig GA, Habicht A, et al. Capillary deposition of complement split product C4d in renal allografts is associated with basement membrane injury in peritubular and glomerular capillaries: a contribution of humoral immunity to chronic allograft rejection. J Am Soc Nephrol. 2002;13:2371–2380Haas M, Montgomery RA, Segev DL, et al. Subclinical acute antibody-mediated rejection in positive crossmatch renal allografts. Am Transplant. 2007;7:576–585
  24. Williams JM, Holzknecht ZE, Plummer B, et al. Acute vascular rejection and accommodation: divergent outcomes of the humoral response to organ transplantation. Transplantation. 2004;78:1471–1478
  25. Keren A, Hayes HM, O'Driscoll G. Late humoral rejection in a cardiac transplant recipient treated with the anti-CD20 monoclonal antibody rituximab. Transplant Proc. 2006;38:1520–1522
  26. Hosenpud JD, Kimberly A, Hogan KB. Cardiac allograft vasculopathy: IgM antibody responses to donor-specific vascular endothelium. Transplantation. 1997;63:1602–1606

PII: S1053-2498(09)01580-0

doi: 10.1016/j.healun.2009.12.018

The Journal of Heart and Lung Transplantation
Volume 29, Issue 4 , Pages 417-423 , April 2010

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