The Journal of Heart and Lung Transplantation
Volume 29, Issue 6 , Pages 610-615 , June 2010

Pulmonary arterial size and response to sildenafil in chronic thromboembolic pulmonary hypertension

  • Mark R. Toshner, MB ChB

      Affiliations

    • Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK
    • Department of Respiratory, Pulmonary Vascular Diseases Unit, Papworth Hospital NHS Trust, Papworth Everard, Cambridgeshire, UK
    • ,
  • Deepa Gopalan, MB ChB

      Affiliations

    • Department of Respiratory, Pulmonary Vascular Diseases Unit, Papworth Hospital NHS Trust, Papworth Everard, Cambridgeshire, UK
    • ,
  • Jay Suntharalingam, MB ChB

      Affiliations

    • Royal United Hospital, Bath, UK
    • ,
  • Carmen Treacy

      Affiliations

    • Department of Respiratory, Pulmonary Vascular Diseases Unit, Papworth Hospital NHS Trust, Papworth Everard, Cambridgeshire, UK
    • ,
  • Elaine Soon, MB ChB

      Affiliations

    • Department of Respiratory, Pulmonary Vascular Diseases Unit, Papworth Hospital NHS Trust, Papworth Everard, Cambridgeshire, UK
    • ,
  • Karen K. Sheares, MB ChB

      Affiliations

    • Department of Respiratory, Pulmonary Vascular Diseases Unit, Papworth Hospital NHS Trust, Papworth Everard, Cambridgeshire, UK
    • ,
  • Nicholas W. Morrell, MB ChB

      Affiliations

    • Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK
    • ,
  • Nicholas Screaton, MB ChB

      Affiliations

    • Department of Respiratory, Pulmonary Vascular Diseases Unit, Papworth Hospital NHS Trust, Papworth Everard, Cambridgeshire, UK
    • ,
  • Joanna Pepke-Zaba, MD

      Affiliations

    • Department of Respiratory, Pulmonary Vascular Diseases Unit, Papworth Hospital NHS Trust, Papworth Everard, Cambridgeshire, UK
    • Corresponding Author InformationReprint requests: Joanna Pepke-Zaba, MD, Pulmonary Vascular Diseases Unit, Papworth Hospital, Papworth Everard, Cambridgeshire CB23 8RE, UK. Telephone: +44-14-80-830541. Fax: +44-14-80-364998

  • Image Result

    Time-line of trial protocol. ADR, adverse drug reaction.

    Time-line of trial protocol. ADR, adverse drug reaction.

  • Image Result

    Correlations of baseline PA distensibility, as measured by relative area change (RAC) of right main pulmonary artery, with 6MWT improvement and NT pro-BNP at 1 year. PAD correlated with improvement in

    Correlations of baseline PA distensibility, as measured by relative area change (RAC) of right main pulmonary artery, with 6MWT improvement and NT pro-BNP at 1 year. PAD correlated with improvement in 6MWT for (A) all subjects and (B) post-PEA only. PAD correlated with change in NT pro-BNP for (C) all subjects and (D) post-PEA only. **p < 0.05.

  • Image Result
    Comparison of RAC in patients who improved NHYA class at 1 year vs those who did did not improve NYHA class. RAC, relative area change (%).

    Comparison of RAC in patients who improved NHYA class at 1 year vs those who did did not improve NYHA class. RAC, relative area change (%).

PII: S1053-2498(09)01535-6

doi: 10.1016/j.healun.2009.12.014

The Journal of Heart and Lung Transplantation
Volume 29, Issue 6 , Pages 610-615 , June 2010

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