The Journal of Heart and Lung Transplantation
Volume 29, Issue 6 , Pages 695-697, June 2010

Increase in circadian variation after continuous-flow ventricular assist device implantation

  • Mark S. Slaughter, MD

      Affiliations

    • Department of Surgery, University of Louisville, Louisville, KY
    • Corresponding Author InformationReprint requests: Mark S. Slaughter, MD, Division of Thoracic and Cardiovascular Surgery, 201 Abraham Flexner Way, Ste 1200, University of Louisville, Louisville, KY 40202. Telephone: 502-561-2180. Fax: 502-561-2190
    • ,
  • Michael S. Ising

      Affiliations

    • Department of Bioengineering, University of Louisville, Louisville, KY
    • ,
  • Daniel Tamez, BS

      Affiliations

    • Department of HeartWare Inc, Miami Lakes, Florida
    • ,
  • Gerry O'Driscoll, MD

      Affiliations

    • Department of Royal Perth Hospital, Perth, Western Australia, Australia
    • ,
  • Neil Voskoboynikov, BS

      Affiliations

    • Department of HeartWare Inc, Miami Lakes, Florida
    • ,
  • Carlo R. Bartoli, MLA

      Affiliations

    • Department of Surgery, University of Louisville, Louisville, KY
    • ,
  • Steven C. Koenig, PhD

      Affiliations

    • Department of Surgery, University of Louisville, Louisville, KY
    • Department of Bioengineering, University of Louisville, Louisville, KY
    • ,
  • Guruprasad A. Giridharan, PhD

      Affiliations

    • Department of Bioengineering, University of Louisville, Louisville, KY

published online 08 March 2010.

The circadian rhythm of varying blood pressure and heart rate is attenuated or absent in patients with severe heart failure. In 28 patients supported by a left ventricular assist device (LVAD) for at least 30 days, a restoration of the circadian rhythm was demonstrated by a consistent nocturnal decrease, and then increase, of the LVAD flow while at a constant LVAD speed. The return of the circadian rhythm has implications for cardiac recovery, and the observation indicates that the continuous-flow LVAD has an intrinsic automatic response to physiologic demands.

Key words: heart failure, circadian rhythm, ventricular assist devices, diurnal variation

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PII: S1053-2498(09)01527-7

doi:10.1016/j.healun.2009.12.006

The Journal of Heart and Lung Transplantation
Volume 29, Issue 6 , Pages 695-697, June 2010

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