The Journal of Heart and Lung Transplantation
Volume 29, Issue 5 , Pages 568-573 , May 2010

Induced pulsation of a continuous-flow total artificial heart in a mock circulatory system

  • Hassan A. Khalil, BS

      Affiliations

    • Cardiovascular Surgical Research Laboratories, Texas Heart Institute at St. Luke's Episcopal Hospital, Houston, Texas
    • The University of Texas Medical School at Houston, Houston, Texas
    • ,
  • Daniel T. Kerr, BS

      Affiliations

    • Cardiovascular Surgical Research Laboratories, Texas Heart Institute at St. Luke's Episcopal Hospital, Houston, Texas
    • ,
  • Mark A. Schusterman II, BS

      Affiliations

    • Cardiovascular Surgical Research Laboratories, Texas Heart Institute at St. Luke's Episcopal Hospital, Houston, Texas
    • ,
  • William E. Cohn, MD

      Affiliations

    • Cardiovascular Surgical Research Laboratories, Texas Heart Institute at St. Luke's Episcopal Hospital, Houston, Texas
    • ,
  • O.H. Frazier, MD

      Affiliations

    • Cardiovascular Surgical Research Laboratories, Texas Heart Institute at St. Luke's Episcopal Hospital, Houston, Texas
    • The University of Texas Medical School at Houston, Houston, Texas
    • Corresponding Author InformationReprint requests: O.H. Frazier, MD, Department of Cardiovascular Surgery, Texas Heart Institute, P.O. Box 20345, MC 3-147, Houston, TX 77225-0345. Telephone: 832-355-3000. Fax: 832-355-6798
    • ,
  • Branislav Radovancevic, MD

      Affiliations

    • Cardiovascular Surgical Research Laboratories, Texas Heart Institute at St. Luke's Episcopal Hospital, Houston, Texas
    • The University of Texas Medical School at Houston, Houston, Texas

References 

  1. Kirklin JK, Holman WL. Mechanical circulatory support therapy as a bridge to transplant or recovery (new advances). Curr Opin Cardiol. 2006;21:120–126
  2. Radovancevic B, Vrtovec B, de Kort E, et al. End-organ function in patients on long-term circulatory support with continuous- or pulsatile-flow assist devices. J Heart Lung Transplant. 2007;26:815–818
  3. Frazier OH, Tuzun E, Cohn W, et al. Total heart replacement with dual centrifugal ventricular assist devices. ASAIO J. 2005;51:224–229
  4. Frazier OH, Tuzun E, Cohn WE, et al. Total heart replacement using dual intracorporeal continuous-flow pumps in a chronic bovine model: a feasibility study. ASAIO J. 2006;52:145–149
  5. Khalil HA, Kerr DT, Franchek MA, et al. Continuous flow total artificial heart: modeling and feedback control in a mock circulatory system. ASAIO J. 2008;54:249–255
  6. Wilmer WN, O'Rourke MF. McDonald's blood flow in arteries, 4th ed. New York: Oxford University Press; 1998;
  7. Undar A, Zapanta CM, Reibson JD, et al. Precise quantification of pressure flow waveforms of a pulsatile ventricular assist device. ASAIO J. 2005;51:56–59
  8. Chapra SC, Canale RP. Numerical methods for engineers: with software and programming applications. 4th ed.. New York: McGraw-Hill; 2002;
  9. Vandenberghe S, Segers P, Antaki JF, et al. Hemodynamic modes of ventricular assist with a rotary blood pump: continuous, pulsatile, and failure. ASAIO J. 2005;51:711–718
  10. Tuzun E, Gregoric ID, Conger JL, et al. The effect of intermittent low speed mode upon aortic valve opening in calves supported with a Jarvik 2000 axial flow device. ASAIO J. 2005;51:139–143
  11. Tuzun E. Induced pulsatility with a continuous flow device. ASAIO J. 2007;53:61A
  12. Bourque K, Dague C, Farrar D, et al. In vivo assessment of a rotary left ventricular assist device-induced artificial pulse in the proximal and distal aorta. Artif Organs. 2006;30:638–642
  13. Bidani A, Flumerfelt RW, Crandall ED. Analysis of the effects of pulsatile capillary blood flow and volume on gas exchange. Respir Physiol. 1978;35:27–42
  14. Bosman AR, Lee GD, Marshall R. The effect of pulsatile capillary blood flow upon gas exchange within the lungs of man. Clin Sci. 1965;28:295–309
  15. Sakaki M, Taenaka Y, Tatsumi E, et al. Influences of nonpulsatile pulmonary flow on pulmonary function (Evaluation in a chronic animal model). J Thorac Cardiovasc Surg. 1994;108:495–502
  16. Lin GS, Spratt RS. Hemodynamic imaging with pulsatility-index and resistive-index color Doppler US. Radiology. 1997;204:870–873

PII: S1053-2498(09)01525-3

doi: 10.1016/j.healun.2009.12.004

The Journal of Heart and Lung Transplantation
Volume 29, Issue 5 , Pages 568-573 , May 2010

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