The Journal of Heart and Lung Transplantation
Volume 29, Issue 5 , Pages 574-577 , May 2010

A regenerative strategy for heart failure in hypoplastic left heart syndrome: Intracoronary administration of autologous bone marrow-derived progenitor cells

  • Stefan Rupp, MD

      Affiliations

    • Pediatric Heart Center, Justus-Liebig University Giessen, Giessen, Germany
    • ,
  • Andreas M. Zeiher, MD

      Affiliations

    • Department of Cardiology, Wolfgang Goethe University Frankfurt, Frankfurt, Germany
    • ,
  • Stefanie Dimmeler, PhD

      Affiliations

    • Department of Cardiology, Wolfgang Goethe University Frankfurt, Frankfurt, Germany
    • ,
  • Torsten Tonn, MD

      Affiliations

    • Institute for Transfusion Medicine and Immunohaematology, Red Cross Blood Donor Service Baden–Württemberg–Hessen, Frankfurt am Main, Germany
    • ,
  • Juergen Bauer, MD

      Affiliations

    • Pediatric Heart Center, Justus-Liebig University Giessen, Giessen, Germany
    • ,
  • Christian Jux, MD

      Affiliations

    • Pediatric Heart Center, Justus-Liebig University Giessen, Giessen, Germany
    • ,
  • Hakan Akintuerk, MD

      Affiliations

    • Pediatric Heart Center, Justus-Liebig University Giessen, Giessen, Germany
    • ,
  • Dietmar Schranz, MD

      Affiliations

    • Pediatric Heart Center, Justus-Liebig University Giessen, Giessen, Germany
    • Corresponding Author InformationReprint requests: Dietmar Schranz, MD, Pediatric Heart Center, Justus-Liebig University Feulgenstrasse 12, 35385 Giessen, Germany. Telephone: 049-641-9943461. Fax: 049-641-9943469

References 

  1. Jessup M, Abraham WT, Casey DE, et al. 2009 focused update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation. 2009;119:1977–2016
  2. Rosenthal D, Chrisant MR, Edens E, et al. International Society for Heart and Lung Transplantation: practice guidelines for management of heart failure in children. J Heart Lung Transplant. 2004;23:1313–1333
  3. Canter CE, Shaddy RE, Bernstein D, et al. Indications for heart transplantation in pediatric heart disease: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young; the Councils on Clinical Cardiology, Cardiovascular Nursing, and Cardiovascular Surgery and Anesthesia; and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation. 2007;115:658–676
  4. Almond CS, Thiagarajan RR, Piercey GE, et al. Waiting list mortality among children listed for heart transplantation in the United States. Circulation. 2009;119:717–727
  5. Rupp S, Bauer J, Tonn T, et al. Intracoronary administration of autologous bone marrow-derived progenitor cells in a critically ill two-yr-old child with dilated cardiomyopathy. Pediatr Transplant. 2009;13:620–623
  6. Akintuerk H, Michel-Behnke I, Valeske K, et al. Stenting of the arterial duct and banding of the pulmonary arteries: basis for combined Norwood stage I and II repair in hypoplastic left heart. Circulation. 2002;105:1099–1103
  7. Assmus B, Schachinger V, Teupe C, et al. Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI). Circulation. 2002;106:3009–3017
  8. Schachinger V, Erbs S, Elsasser A, et al. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med. 2006;355:1210–1221
  9. Lange R, Vogt M, Horer J, et al. Long-term results of repair of anomalous origin of the left coronary artery from the pulmonary artery. Ann Thorac Surg. 2007;83:1463–1471
  10. Abdel-Latif A, Bolli R, Tleyjeh IM, et al. Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis. Arch Intern Med. 2007;167:989–997
  11. Dimmeler S, Burchfield J, Zeiher AM. Cell-based therapy of myocardial infarction. Arterioscler Thromb Vasc Biol. 2008;28:208–216
  12. Dimmeler S, Zeiher AM, Schneider MD. Unchain my heart: the scientific foundations of cardiac repair. J Clin Invest. 2005;115:572–583
  13. Rupp S, Koyanagi M, Iwasaki M, et al. Genetic proof-of-concept for cardiac gene expression in human circulating blood-derived progenitor cells. J Am Coll Cardiol. 2008;51:2289–2290
  14. Gnecchi M, He H, Liang OD, et al. Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med. 2005;11:367–368
  15. Beltrami AP, Barlucchi L, Torella D, et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell. 2003;114:763–776
  16. Diller GP, van Eijl S, Okonko DO, et al. Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension. Circulation. 2008;117:3020–3030
  17. Bahlmann FH, De Groot K, Spandau JM. Erythropoietin regulates endothelial progenitor cells. Blood. 2004;103:921–926
  18. Aicher A, Zeiher AM, Dimmeler S. Mobilizing endothelial progenitor cells. Hypertension. 2005;45:321–325

PII: S1053-2498(09)00818-3

doi: 10.1016/j.healun.2009.10.006

The Journal of Heart and Lung Transplantation
Volume 29, Issue 5 , Pages 574-577 , May 2010

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