The Journal of Heart and Lung Transplantation
Volume 29, Issue 5 , Pages 574-577, May 2010

A regenerative strategy for heart failure in hypoplastic left heart syndrome: Intracoronary administration of autologous bone marrow-derived progenitor cells

  • Stefan Rupp, MD

      Affiliations

    • Pediatric Heart Center, Justus-Liebig University Giessen, Giessen, Germany
    • ,
  • Andreas M. Zeiher, MD

      Affiliations

    • Department of Cardiology, Wolfgang Goethe University Frankfurt, Frankfurt, Germany
    • ,
  • Stefanie Dimmeler, PhD

      Affiliations

    • Department of Cardiology, Wolfgang Goethe University Frankfurt, Frankfurt, Germany
    • ,
  • Torsten Tonn, MD

      Affiliations

    • Institute for Transfusion Medicine and Immunohaematology, Red Cross Blood Donor Service Baden–Württemberg–Hessen, Frankfurt am Main, Germany
    • ,
  • Juergen Bauer, MD

      Affiliations

    • Pediatric Heart Center, Justus-Liebig University Giessen, Giessen, Germany
    • ,
  • Christian Jux, MD

      Affiliations

    • Pediatric Heart Center, Justus-Liebig University Giessen, Giessen, Germany
    • ,
  • Hakan Akintuerk, MD

      Affiliations

    • Pediatric Heart Center, Justus-Liebig University Giessen, Giessen, Germany
    • ,
  • Dietmar Schranz, MD

      Affiliations

    • Pediatric Heart Center, Justus-Liebig University Giessen, Giessen, Germany
    • Corresponding Author InformationReprint requests: Dietmar Schranz, MD, Pediatric Heart Center, Justus-Liebig University Feulgenstrasse 12, 35385 Giessen, Germany. Telephone: 049-641-9943461. Fax: 049-641-9943469

published online 04 January 2010.

Novel surgical strategies have dramatically improved the initial outcome of newborns with hypoplastic left heart syndrome. However, the single systemic right ventricle remains a major challenge, with limited effectiveness of pharmacologic therapy. The present case documents that the intracoronary administration of autologous bone marrow-derived progenitor cells is technically feasible in a critically ill infant with hypoplastic left heart syndrome and severe heart failure after a hybrid comprehensive stage II procedure. Cell therapy might represent an option before heart transplantation in children with single ventricle physiology presenting with severe heart failure.

Keywords: HLHS, heart failure, autologous stem cell therapy

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PII: S1053-2498(09)00818-3

doi:10.1016/j.healun.2009.10.006

The Journal of Heart and Lung Transplantation
Volume 29, Issue 5 , Pages 574-577, May 2010

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