The Journal of Heart and Lung Transplantation
Volume 29, Issue 4 , Pages 432-438 , April 2010

Clinical outcomes after cardiac transplantation in muscular dystrophy patients

  • Roland S. Wu, MD

      Affiliations

    • Department of Internal Medicine, University of Texas Southwestern Medical Center
    • Contributed equally to the manuscript.
    • ,
  • Sachin Gupta, MD

      Affiliations

    • Department of Internal Medicine, University of Texas Southwestern Medical Center
    • Contributed equally to the manuscript.
    • ,
  • Robert N. Brown, MS

      Affiliations

    • Cardiac Transplant Research Database, University of Alabama at Birmingham
    • ,
  • Clyde W. Yancy, MD

      Affiliations

    • Department of Internal Medicine, University of Texas Southwestern Medical Center
    • Current address is Department of Internal Medicine, Baylor University Medical Center
    • ,
  • Joyce W. Wald, MD

      Affiliations

    • Department of Internal Medicine, Temple University
    • Current address is Department of Internal Medicine, University of Pennsylvania
    • ,
  • Patricia Kaiser, RN

      Affiliations

    • Department of Internal Medicine, University of Texas Southwestern Medical Center
    • ,
  • Nicole M. Kirklin, BA

      Affiliations

    • Cardiac Transplant Research Database, University of Alabama at Birmingham
    • ,
  • Parag C. Patel, MD

      Affiliations

    • Department of Internal Medicine, University of Texas Southwestern Medical Center
    • Donald W. Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center
    • ,
  • David W. Markham, MD

      Affiliations

    • Department of Internal Medicine, University of Texas Southwestern Medical Center
    • Donald W. Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center
    • ,
  • Mark H. Drazner, MD, MSc

      Affiliations

    • Department of Internal Medicine, University of Texas Southwestern Medical Center
    • Donald W. Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center
    • ,
  • Daniel J. Garry, MD, PhD

      Affiliations

    • Department of Internal Medicine, University of Texas Southwestern Medical Center
    • Donald W. Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center
    • Current address is Lillehei Heart Institute, University of Minnesota Medical School
    • ,
  • Pradeep P.A. Mammen, MD

      Affiliations

    • Department of Internal Medicine, University of Texas Southwestern Medical Center
    • Donald W. Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center
    • Corresponding Author InformationReprint requests: Pradeep P. A. Mammen, MD, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, NB10.228, Dallas, TX 75390-8573. Telephone: 214-648-4994. Fax: 214-648-1450

References 

  1. Blake DJ, Weir A, Newey SE, Davies KE. Function and genetics of dystrophin and dystrophin-related proteins in muscle. Physiol Rev. 2002;82:291–329
  2. Emery AE. The muscular dystrophies. Lancet. 2002;359:687–695
  3. Cohn RD, Campbell KP. Molecular basis of muscular dystrophies. Muscle Nerve. 2000;23:1456–1471
  4. Finsterer J, Stollberger C. The heart in human dystrophinopathies. Cardiology. 2003;99:1–19
  5. Gnecchi-Ruscone T, Taylor J, Mercuri E, et al. Cardiomyopathy in Duchenne, Becker, and sarcoglycanopathies: a role for coronary dysfunction?. Muscle Nerve. 1999;22:1549–1556
  6. Michele DE, Campbell KP. Cardiomyopathy in muscular dystrophies. In:  Walsh RA editors. Molecular mechanisms of cardiac hypertrophy and failure. London: Taylor & Francis; 2005;p. 541–567
  7. Cohn RD, Campbell KP. Molecular pathways for dilated cardiomyopathy. In:  Chien K editors. Molecular basis of cardiovascular disease: a companion to Braunwald's heart disease. 2nd ed.. Philadelphia: Saunders; 2004;p. 306–310
  8. Casazza F, Brambilla G, Salvato A, Morandi L, Gronda E, Bonacina E. Cardiac transplantation in Becker muscular dystrophy. J Neurol. 1988;235:496–498
  9. D'Amico A, Petrini S, Parisi F, et al. Heart transplantation in a child with LGMD2I presenting as isolated dilated cardiomyopathy. Neuromuscul Disord. 2008;18:153–155
  10. Dell'Amore A, Botta L, Martin Suarez S, et al. Heart transplantation in patients with Emery-Dreifuss muscular dystrophy: case reports. Transplant Proc. 2007;39:3538–3540
  11. Donofrio PD, Challa VR, Hackshaw BT, Mills SA, Cordell AR. Cardiac transplantation in a patient with muscular dystrophy and cardiomyopathy. Arch Neurol. 1989;46:705–707
  12. Finsterer J, Bittner RE, Grimm M. Cardiac involvement in Becker's muscular dystrophy, necessitating heart transplantation, 6 years before apparent skeletal muscle involvement. Neuromuscul Disord. 1999;9:598–600
  13. Kichuk Chrisant MR, Drummond-Webb J, Hallowell S, Friedman NR. Cardiac transplantation in twins with autosomal dominant Emery-Dreifuss muscular dystrophy. J Heart Lung Transplant. 2004;23:496–498
  14. Leprince P, Heloire F, Eymard B, Leger P, Duboc D, Pavie A. Successful bridge to transplantation in a patient with Becker muscular dystrophy-associated cardiomyopathy. J Heart Lung Transplant. 2002;21:822–824
  15. Merchut MP, Zdonczyk D, Gujrati M. Cardiac transplantation in female Emery-Dreifuss muscular dystrophy. J Neurol. 1990;237:316–319
  16. Duboc D, Meune C, Lerebours G, Devaux JY, Vaksmann G, Becane HM. Effect of perindopril on the onset and progression of left ventricular dysfunction in Duchenne muscular dystrophy. J Am Coll Cardiol. 2005;45:855–857
  17. Kajimoto H, Ishigaki K, Okumura K, et al. Beta-blocker therapy for cardiac dysfunction in patients with muscular dystrophy. Circ J. 2006;70:991–994
  18. Bushby K, Muntoni F, Bourke JP. 107th ENMC international workshop: The management of cardiac involvement in muscular dystrophy and myotonic dystrophy (7th-9th June 2002, Naarden, The Netherlands). Neuromuscul Disord. 2003;13:166–172
  19. Melacini P, Gambino A, Caforio A, et al. Heart transplantation in patients with inherited myopathies associated with end-stage cardiomyopathy: molecular and biochemical defects on cardiac and skeletal muscle. Transplant Proc. 2001;33:1596–1599
  20. Rees W, Schuler S, Hummel M, Hetzer R. Heart transplantation in patients with muscular dystrophy associated with end-stage cardiomyopathy. J Heart Lung Transplant. 1993;12:804–807
  21. Anthuber M, Kemkes BM, Schuetz A, et al. Heart transplantation in patients with “so-called” contraindications. Transplant Proc. 1990;22:1451–1453
  22. Patane F, Zingarelli E, Attisani M, Sansone F. Successful heart transplantation in Becker's muscular dystrophy. Eur J Cardiothorac Surg. 2006;29:250
  23. Ruiz-Cano MJ, Delgado JF, Jimenez C, et al. Successful heart transplantation in patients with inherited myopathies associated with end-stage cardiomyopathy. Transplant Proc. 2003;35:1513–1515

PII: S1053-2498(09)00718-9

doi: 10.1016/j.healun.2009.08.030

The Journal of Heart and Lung Transplantation
Volume 29, Issue 4 , Pages 432-438 , April 2010

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