The Journal of Heart and Lung Transplantation
Volume 29, Issue 4 , Pages 401-409 , April 2010

The role of recipient mast cells in acute and chronic cardiac allograft rejection in C57BL/6-KitW-sh/W-sh mice

  • Satoshi Itoh, MD

      Affiliations

    • Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California
    • ,
  • Susumu Nakae, PhD

      Affiliations

    • Frontier Research Initiative, The Institute of Medical Science, The University of Tokyo, Tokyo
    • ,
  • Jeffrey B. Velotta, MD

      Affiliations

    • Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California
    • ,
  • Hisanori Kosuge, MD

      Affiliations

    • Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California
    • ,
  • Andrew Connolly, MD

      Affiliations

    • Department of Pathology and Microbiology, and Immunology, Stanford University School of Medicine, Stanford, California
    • ,
  • Mindy Tsai, DMSc

      Affiliations

    • Department of Pathology and Microbiology, and Immunology, Stanford University School of Medicine, Stanford, California
    • ,
  • Hideo Adachi, MD

      Affiliations

    • Department of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    • ,
  • Stephen J. Galli, MD

      Affiliations

    • Department of Pathology and Microbiology, and Immunology, Stanford University School of Medicine, Stanford, California
    • ,
  • Robert C. Robbins, MD

      Affiliations

    • Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California
    • ,
  • Michael P. Fischbein, MD, PhD

      Affiliations

    • Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California
    • Corresponding Author InformationReprint requests: Michael P. Fischbein, MD, PhD, Department of Cardiothoracic Surgery, Stanford University School of Medicine, 300 Pasteur Dr, CVRB MC 5407, Stanford, CA 94305. Telephone: 650-725-3828. Fax: 650-725-3846

References 

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  12. Nagle DL, Kozak CA, Mano H, Chapman VM, Bucan M. Physical mapping of the Tec and Gabrb1 loci reveals that the Wsh mutation on mouse chromosome 5 is associated with an inversion. Hum Mol Genet. 1995;4:2073–2079
  13. Berrozpe G, Agosti V, Tucker C, Blanpain C, Manova K, Besmer P. A distant upstream locus control region is critical for expression of the Kit receptor gene in mast cells. Mol Cell Biol. 2006;26:5850–5860
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  17. Armstrong AT, Strauch AR, Starling RC, Sedmak DD, Orosz CG. Morphometric analysis of neointimal formation in murine cardiac allografts. Transplantation. 1997;63:941–947
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  22. Tsujimura T, Hirota S, Nomura S, et al. Characterization of Ws mutant allele of rats: a 12-base deletion in tyrosine kinase domain of c-kit gene. Blood. 1991;78:1942–1946
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  24. Mekori YA, Metcalfe DD. Mast cell-T cell interactions. J Allergy Clin Immunol. 1999;104:517–523
  25. Fischbein MP, Yun J, Laks H, et al. CD8+ lymphocytes augment chronic rejection in a MHC class II mismatched model. Transplantation. 2001;71:1146–1153
  26. Fischbein MP, Yun J, Laks H, et al. Regulated interleukin-10 expression prevents chronic rejection of transplanted hearts. J Thorac Cardiovasc Surg. 2003;126:216–223
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  29. Zweifel M, Hirsiger H, Matozan K, Welle M, Schaffner T, Mohacsi P. Mast cells in ongoing acute rejection: increase in number and expression of a different phenotype in rat heart transplants. Transplantation. 2002;73:1707–1716

PII: S1053-2498(09)00681-0

doi: 10.1016/j.healun.2009.08.019

The Journal of Heart and Lung Transplantation
Volume 29, Issue 4 , Pages 401-409 , April 2010

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