The Journal of Heart and Lung Transplantation
Volume 28, Issue 7 , Pages 704-709 , July 2009

The Change in B-Type Natriuretic Peptide Levels Over Time Predicts Significant Rejection in Cardiac Transplant Recipients

  • Michelle M. Kittleson, MD, PhD

      Affiliations

    • Department of Medicine, Division of Cardiology, University of California at Los Angeles, Los Angeles, California
  • ,
  • Diane V. Skojec, CRNP

      Affiliations

    • Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, Baltimore, Maryland
  • ,
  • Ilan S. Wittstein, MD

      Affiliations

    • Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, Baltimore, Maryland
  • ,
  • Hunter C. Champion, MD, PhD

      Affiliations

    • Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, Baltimore, Maryland
  • ,
  • Daniel P. Judge, MD

      Affiliations

    • Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, Baltimore, Maryland
  • ,
  • Lili A. Barouch, MD

      Affiliations

    • Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, Baltimore, Maryland
  • ,
  • Marc Halushka, MD, PhD

      Affiliations

    • Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland
  • ,
  • Joshua M. Hare, MD

      Affiliations

    • Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, Baltimore, Maryland
  • ,
  • Edward K. Kasper, MD

      Affiliations

    • Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, Baltimore, Maryland
  • ,
  • Stuart D. Russell, MD

      Affiliations

    • Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, Baltimore, Maryland
    • Corresponding Author InformationReprint requests: Stuart D. Russell, MD, Johns Hopkins Hospital, Carnegie 568, 600 N Wolfe St, Baltimore, MD 21287. Telephone: 410-955-5708. Fax: 410-955-3478

Received 19 February 2007 ,Revised 23 February 2009 ,Accepted 10 April 2009.

References 

  1. Deckers JW, Hare JM, Baughman KL. Complications of transvenous right ventricular endomyocardial biopsy in adult patients with cardiomyopathy: a seven-year survey of 546 consecutive diagnostic procedures in a tertiary referral center. J Am Coll Cardiol. 1992;19:43–47
  2. Chen HH, Burnett JC. Natriuretic peptides in the pathophysiology of congestive heart failure. Curr Cardiol Rep. 2000;2:198–205
  3. Maeda K, Tsutamoto T, Wada A, Hisanaga T, Kinoshita M. Plasma brain natriuretic peptide as a biochemical marker of high left ventricular end-diastolic pressure in patients with symptomatic left ventricular dysfunction. Am Heart J. 1998;135:825–832
  4. McDonagh TA, Robb SD, Murdoch DR, et al. Biochemical detection of left-ventricular systolic dysfunction. Lancet. 1998;351:9–13
  5. Maisel AS, Krishnaswamy P, Nowak RM, et al. Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med. 2002;347:161–167
  6. Rothenburger M, Wichter T, Schmid C, et al. Aminoterminal pro type B natriuretic peptide as a predictive and prognostic marker in patients with chronic heart failure. J Heart Lung Transplant. 2004;23:1189–1197
  7. Tsutamoto T, Wada A, Maeda K, et al. Attenuation of compensation of endogenous cardiac natriuretic peptide system in chronic heart failure: prognostic role of plasma brain natriuretic peptide concentration in patients with chronic symptomatic left ventricular dysfunction. Circulation. 1997;96:509–516
  8. Berger R, Huelsman M, Strecker K, et al. B-type natriuretic peptide predicts sudden death in patients with chronic heart failure. Circulation. 2002;105:2392–2397
  9. McDonagh TA, Cunningham AD, Morrison CE, et al. Left ventricular dysfunction, natriuretic peptides, and mortality in an urban population. Heart. 2001;86:21–26
  10. Hunt PJ, Richards AM, Nicholls MG, Yandle TG, Doughty RN, Espiner EA. Immunoreactive amino-terminal pro-brain natriuretic peptide (NT-PROBNP): a new marker of cardiac impairment. Clin Endocrinol (Oxf). 1997;47:287–296
  11. Groenning BA, Raymond I, Hildebrandt PR, Nilsson JC, Baumann M, Pedersen F. Diagnostic and prognostic evaluation of left ventricular systolic heart failure by plasma N-terminal pro-brain natriuretic peptide concentrations in a large sample of the general population. Heart. 2004;90:297–303
  12. Bay M, Kirk V, Parner J, et al. NT-proBNP: a new diagnostic screening tool to differentiate between patients with normal and reduced left ventricular systolic function. Heart. 2003;89:150–154
  13. Kirk V, Bay M, Parner J, et al. N-terminal proBNP and mortality in hospitalised patients with heart failure and preserved vs. reduced systolic function: data from the prospective Copenhagen Hospital Heart Failure Study (CHHF). Eur J Heart Fail. 2004;6:335–341
  14. Hartmann F, Packer M, Coats AJ, et al. NT-proBNP in severe chronic heart failure: rationale, design and preliminary results of the COPERNICUS NT-proBNP substudy. Eur J Heart Fail. 2004;6:343–350
  15. Hammerer-Lercher A, Mair J, Antretter H, et al. B-type natriuretic peptide as a marker of allograft rejection after heart transplantation. J Heart Lung Transplant. 2005;24:1444
  16. Wu AH, Johnson ML, Aaronson KD, Gordon D, Dyke DB, Koelling TM. Brain natriuretic peptide predicts serious cardiac allograft rejection independent of hemodynamic measurements. J Heart Lung Transplant. 2005;24:52–57
  17. Ogawa T, Veinot JP, Davies RA, et al. Neuroendocrine profiling of humans receiving cardiac allografts. J Heart Lung Transplant. 2005;24:1046–1054
  18. Shaw SM, Williams SG. Is brain natriuretic peptide clinically useful after cardiac transplantation?. J Heart Lung Transplant. 2006;25:1396–1401
  19. O'Neill JO, McRae AT, Troughton RW, et al. Brain natriuretic peptide levels do not correlate with acute cellular rejection in de novo orthotopic heart transplant recipients. J Heart Lung Transplant. 2005;24:416–420
  20. Lan YT, Chang RK, Alejos JC, Burch C, Wetzel GT. B-type natriuretic peptide in children after cardiac transplantation. J Heart Lung Transplant. 2004;23:558–563
  21. Arnau-Vives MA, Almenar L, Hervas I, et al. Predictive value of brain natriuretic peptide in the diagnosis of heart transplant rejection. J Heart Lung Transplant. 2004;23:850–856
  22. Stewart S, Winters GL, Fishbein MC, et al. Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant. 2005;24:1710–1720
  23. Zeger SL, Liang KY, Albert PS. Models for longitudinal data: a generalized estimating equation approach. Biometrics. 1988;44:1049–1060
  24. Winters GL, McManus BM. Consistencies and controversies in the application of the International Society for Heart and Lung Transplantation working formulation for heart transplant biopsy specimens (Rapamycin Cardiac Rejection Treatment Trial Pathologists). J Heart Lung Transplant. 1996;15:728–735
  25. Winters GL, Marboe CC, Billingham ME. The International Society for Heart and Lung Transplantation grading system for heart transplant biopsy specimens: clarification and commentary. J Heart Lung Transplant. 1998;17:754–760
  26. Nielsen H, Sorensen FB, Nielsen B, Bagger JP, Thayssen P, Baandrup U. Reproducibility of the acute rejection diagnosis in human cardiac allografts (The Stanford Classification and the International Grading System). J Heart Lung Transplant. 1993;12:239–243
  27. Masters RG, Davies RA, Veinot JP, Hendry PJ, Smith SJ, de Bold AJ. Discoordinate modulation of natriuretic peptides during acute cardiac allograft rejection in humans. Circulation. 1999;100:287–291
  28. Martinez-Dolz L, Almenar L, Hervas I, et al. Prognostic relationship between two serial determinations of B-type natriuretic peptide and medium-long-term events in heart transplantation. J Heart Lung Transplant. 2008;27:735–740
  29. Deng MC, Eisen HJ, Mehra MR, et al. Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling. Am J Transplant. 2006;6:150–160

PII: S1053-2498(09)00241-1

doi: 10.1016/j.healun.2009.04.019

The Journal of Heart and Lung Transplantation
Volume 28, Issue 7 , Pages 704-709 , July 2009