The Journal of Heart and Lung Transplantation
Volume 28, Issue 7 , Pages 743-745 , July 2009

Immune Tolerance After Total Lymphoid Irradiation for Heart Transplantation: Immunosuppressant-free Survival for 8 Years

  • George D. Comerci Jr, MD

      Affiliations

    • Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico
    • Corresponding Author InformationReprint requests: George D. Comerci, Jr, MD, University of New Mexico, Department of Internal Medicine, 5 ACC, 211 Lomas Blvd., Albuquerque, NM 87106. Telephone: 505-272-6476
    • ,
  • Thomas M. Williams, MD

      Affiliations

    • Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico
    • ,
  • Susan Kellie, MD

      Affiliations

    • Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico

Received 9 December 2008 ,Revised 16 March 2009 ,Accepted 7 April 2009.

References 

  1. Hamburger J, Vaysse J, Crosnier J, et al. Renal homotransplantation in man after radiation of the recipient. Am J Med. 1962;32:854–871
  2. Frist WH, Winterland AW, Gerhardt EB, et al. Total lymphoid irradiation in heart transplantation: adjunctive treatment for recurrent rejection. Ann Thorac Surg. 1989;48:863–864
  3. Hunt S, Strober S, Hoppe R, et al. Total Lymphoid Irradiation for treatment of intractable cardiac allograft rejection. J Heart Lung Transplant. 1991;10:211–216
  4. Salter MM, Kirklin JK, Bourge RC, et al. Total lymphoid irradiation in the treatment of early or recurrent heart rejection. J Heart Lung Transplant. 1992;11:902–911
  5. Evans M, Schomberg P, Rodeheffer R, et al. Total lymphoid irradiation: a novel and successful therapy for resistant cardiac allograft rejection. Mayo Clin Proc. 1992;67:785–790
  6. Chin C, Hunt S, Robbins R, et al. Long-term follow-up after total lymphoid irradiation in pediatric heart transplant recipients. J Heart Lung Transplant. 2002;21:667–673
  7. Wolden SL, Tate DJ, Hunt SA, Strober S, Hoppe RT. Long-term results of total lymphoid irradiation in the treatment of cardiac allograft rejection. Int J Radiat Oncol Biol Phys. 1997;39:953–960
  8. Salter SP, Salter MM, Kirklin JK, et al. Total lymphoid irradiation in the treatment of early or recurrent heart transplant rejection. Int J Radiat Oncol Biol Phys. 1995;30:83–88
  9. Lim TS, O'Driscoll G, Freund J, et al. Short-course total lymphoid irradiation for refractory cardiac transplantation rejection. J Heart Lung Transplant. 2007;12:1249–1254
  10. Weiss L, Slavin S. Effect of total lymphoid irradiation on natural killer cells. Isr J Med Sci. 1994;30:253–259
  11. Rohowsky-Kochan C, Molinaro D, Devereux C, et al. The effect of total lymphoid irradiation and low-dose steroids on lymphocyte populations in multiple sclerosis: correlation with clinical and MRI status. J Neuro Sci. 1997;152:182–192
  12. Strober S, Benike C, Krishnaswamy S, et al. Clinical tolerance 12 years after prospective withdrawal of immunosuppressant drugs. Transplantation. 2000;69:1549–1554
  13. Kawai T, Cosimi AB, Spitzer TR, et al. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med. 2008;358:353–361
  14. Scandling J, Busque S, Dejbakhsh-Jones S, et al. Tolerance and immune chimerism after renal and hematopoietic cell transplantation. N Engl J Med. 2008;358:362–368
  15. Corrales-Medinea V, Symes S, Valdivia-Arenas M, Baoulanger C. Localized Mycobacterium avium complex infection of vertebral and paravertebral structures in an HIV patient on highly active antiretroviral therapy. South Med J. 2006;99:174–177
  16. Aberg JA, Chin-Hong PV, McCutchan A, Koletar SL, Currier JS. Localized osteomyelitis due to Mycobacterium avium complex in patients with human immunodeficiency virus receiving highly active antiviral therapy. Clin Infect Dis. 2002;35:E8–E13

PII: S1053-2498(09)00233-2

doi: 10.1016/j.healun.2009.04.011

The Journal of Heart and Lung Transplantation
Volume 28, Issue 7 , Pages 743-745 , July 2009

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