The Journal of Heart and Lung Transplantation
Volume 28, Issue 7 , Pages 697-703 , July 2009

Tacrolimus and Azathioprine Versus Cyclosporine and Mycophenolate Mofetil After Lung Transplantation: A Retrospective Cohort Study

  • Muhammet R. Celik, MD

      Affiliations

    • Department of Surgery, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York
    • ,
  • David J. Lederer, MD, MS

      Affiliations

    • Department of Medicine, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York
    • ,
  • Jessie Wilt, MD

      Affiliations

    • Department of Medicine, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York
    • ,
  • Dilek Eser, MD

      Affiliations

    • Hacettepe University School of Medicine, Ankara, Turkey
    • ,
  • Matthew Bacchetta, MD

      Affiliations

    • Department of Surgery, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York
    • ,
  • Frank D'Ovidio, MD, PhD

      Affiliations

    • Department of Surgery, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York
    • ,
  • Joshua R. Sonett, MD

      Affiliations

    • Department of Surgery, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York
    • ,
  • Selim M. Arcasoy, MD

      Affiliations

    • Department of Medicine, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York
    • Corresponding Author InformationReprint requests: Selim M. Arcasoy, MD, New York Presbyterian Hospital of Columbia and Cornell University, PH 14E, Rm 104, 622 W 168th St, New York, NY, 10032. Telephone: 212-305-6589. Fax: 212-342-5382

Received 10 December 2008 ,Revised 11 March 2009 ,Accepted 7 April 2009.

References 

  1. Trulock EP, Christie JD, Edwards LB, et al. Registry of the International Society for Heart and Lung Transplantation: twenty-fourth official adult lung and heart-lung transplantation report-2007. J Heart Lung Transplant. 2007;26:782–795
  2. Boehler A, Estenne M. Obliterative bronchiolitis after lung transplantation. Curr Opin Pulm Med. 2000;6:133–139
  3. Briffa N, Morris RE. New immunosuppressive regimens in lung transplantation. Eur Respir J. 1997;10:2630–2637
  4. Husain AN, Siddiqui MT, Holmes EW, et al. Analysis of risk factors for the development of bronchiolitis obliterans syndrome. Am J Respir Crit Care Med. 1999;159:829–833
  5. Estenne M, Maurer JR, Boehler A, et al. Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria. J Heart Lung Transplant. 2002;21:297–310
  6. Glanville AR, Aboyoun CL, Havryk A, Plit M, Rainer S, Malouf MA. Severity of lymphocytic bronchiolitis predicts long-term outcome after lung transplantation. Am J Respir Crit Care Med. 2008;177:1033–1040
  7. International guidelines for the selection of lung transplant candidates (The American Society for Transplant Physicians (ASTP)/American Thoracic Society (ATS)/European Respiratory Society (ERS)/International Society for Heart and Lung Transplantation(ISHLT)). Am J Respir Crit Care Med. 1998;158:335–339
  8. Yousem SA, Berry GJ, Cagle PT, et al. Revision of the 1990 working formulation for the classification of pulmonary allograft rejection: Lung Rejection Study Group. J Heart Lung Transplant. 1996;15:1–15
  9. Hachem RR, Yusen RD, Chakinala MM, et al. A randomized controlled trial of tacrolimus versus cyclosporine after lung transplantation. J Heart Lung Transplant. 2007;26:1012–1018
  10. Keenan RJ, Konishi H, Kawai A, et al. Clinical trial of tacrolimus versus cyclosporine in lung transplantation. Ann Thorac Surg. 1995;60:580–584discussion 584–5
  11. Treede H, Klepetko W, Reichenspurner H, et al. Tacrolimus versus cyclosporine after lung transplantation: a prospective, open, randomized two-center trial comparing two different immunosuppressive protocols. J Heart Lung Transplant. 2001;20:511–517
  12. Zuckermann A, Reichenspurner H, Birsan T, et al. Cyclosporine A versus tacrolimus in combination with mycophenolate mofetil and steroids as primary immunosuppression after lung transplantation: one-year results of a 2-center prospective randomized trial. J Thorac Cardiovasc Surg. 2003;125:891–900
  13. Reichenspurner H. Overview of tacrolimus-based immunosuppression after heart or lung transplantation. J Heart Lung Transplant. 2005;24:119–130
  14. McCurry KR, Iacono AT, Dauber JH, et al. Lung and heart-lung transplantation at the University of Pittsburgh. Clin Transpl. 1997;209–218
  15. Reichenspurner H, Kur F, Treede H, et al. Optimization of the immunosuppressive protocol after lung transplantation. Transplantation. 1999;68:67–71
  16. Ross DJ, Waters PF, Levine M, Kramer M, Ruzevich S, Kass RM. Mycophenolate mofetil versus azathioprine immunosuppressive regimens after lung transplantation: preliminary experience. J Heart Lung Transplant. 1998;17:768–774
  17. Zuckermann A, Klepetko W, Birsan T, et al. Comparison between mycophenolate mofetil- and azathioprine-based immunosuppressions in clinical lung transplantation. J Heart Lung Transplant. 1999;18:432–440
  18. Palmer SM, Baz MA, Sanders L, et al. Results of a randomized, prospective, multicenter trial of mycophenolate mofetil versus azathioprine in the prevention of acute lung allograft rejection. Transplantation. 2001;71:1772–1776
  19. McNeil K, Glanville AR, Wahlers T, et al. Comparison of mycophenolate mofetil and azathioprine for prevention of bronchiolitis obliterans syndrome in de novo lung transplant recipients. Transplantation. 2006;81:998–1003
  20. Lama VN, Murray S, Lonigro RJ, et al. Course of FEV(1) after onset of bronchiolitis obliterans syndrome in lung transplant recipients. Am J Respir Crit Care Med. 2007;175:1192–1198
  21. Miettinen OS. The need for randomization in the study of intended effects. Stat Med. 1983;2:267–271

 Funding was provided by Astellas Inc.

PII: S1053-2498(09)00232-0

doi: 10.1016/j.healun.2009.04.010

The Journal of Heart and Lung Transplantation
Volume 28, Issue 7 , Pages 697-703 , July 2009

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