The Journal of Heart and Lung Transplantation
Volume 28, Issue 7 , Pages 725-732 , July 2009

Alteration of Neuropeptides in the Lung Tissue Correlates Brain Death-Induced Neurogenic Edema

  • Anne Barklin, MD, PhD

      Affiliations

    • Department of Anesthesiology, Aarhus University Hospital, Aarhus, Denmark
    • Corresponding Author InformationReprint requests: Anne Barklin, Department of Anesthesiology, Aarhus Universital Hospital, Noerrebrogade 44, Building 1C, 1st, 8000 Aarhus C, Denmark. Telephone: +45-8949-2852
    • ,
  • Elvar Theodorsson, DMSc

      Affiliations

    • IKE/Clinical Chemistry, University Hospital, Linköping, Sweden
    • ,
  • Stig S. Tyvold, MD

      Affiliations

    • Department of Circulation and Medical Imaging, The Norwegian University of Science and Technology (NTNU), Trondheim, Norway
    • ,
  • Anders Larsson, DMSc

      Affiliations

    • Department of Anesthesiology, Aarhus University Hospital, Aarhus, Denmark
    • ,
  • Asger Granfeldt, MD

      Affiliations

    • Department of Anesthesiology, Aarhus University Hospital, Aarhus, Denmark
    • ,
  • Erik Sloth, MDSc

      Affiliations

    • Department of Anesthesiology, Aarhus University Hospital, Aarhus, Denmark
    • ,
  • Else Tonnesen, DMSc

      Affiliations

    • IKE/Clinical Chemistry, University Hospital, Linköping, Sweden

Received 1 December 2008 ,Revised 23 February 2009 ,Accepted 7 April 2009.

References 

  1. Snell GI, Griffiths A, Levvey BJ, Oto T. Availability of lungs for transplantation: exploring the real potential of the donor pool. J Heart Lung Transplant. 2008;27:662–667
  2. Trulock EP. Lung transplantation. Am J Respir Crit Care Med. 1997;155:789–818
  3. Baumann A, Audibert G, McDonnell J, Mertes PM. Neurogenic pulmonary edema. Acta Anaesthesiol Scand. 2007;51:447–455
  4. Fontes RB, Aguiar PH, Zanetti MV, Andrade F, Mandel M, Teixeira MJ. Acute neurogenic pulmonary edema: case reports and literature review. J Neurosurg Anesthesiol. 2003;15:144–150
  5. Avlonitis VS, Fisher AJ, Kirby JA, Dark JH. Pulmonary transplantation: the role of brain death in donor lung injury. Transplantation. 2003;75:1928–1933
  6. Sakakibara H, Hashiba Y, Taki K, Kawanishi M, Shimada Y, Ishikawa N. Effect of sympathetic nerve stimulation on lung vascular permeability in the rat. Am Rev Respir Dis. 1992;145:685–692
  7. Groneberg DA, Folkerts G, Peiser C, Chung KF, Fischer A. Neuropeptide Y (NPY). Pulm Pharmacol Ther. 2004;17:173–180
  8. Hamdy O, Nishiwaki K, Yajima M, et al. Presence and quantification of neuropeptide Y in pulmonary edema fluids in rats. Exp Lung Res. 2000;26:137–147
  9. Hirabayashi A, Nishiwaki K, Shimada Y, Ishikawa N. Role of neuropeptide Y and its receptor subtypes in neurogenic pulmonary edema. Eur J Pharmacol. 1996;296:297–305
  10. McDonald DM, Bowden JJ, Baluk P, Bunnett NW. Neurogenic inflammation (A model for studying efferent actions of sensory nerves). Adv Exp Med Biol. 1996;410:453–462
  11. Barnes PJ. Neurogenic inflammation in the airways. Respir Physiol. 2001;125:145–154
  12. Coleridge JC, Coleridge HM. Afferent vagal C fibre innervation of the lungs and airways and its functional significance. Rev Physiol Biochem Pharmacol. 1984;99:1–110
  13. Dakhama A, Larsen GL, Gelfand EW. Calcitonin gene-related peptide: role in airway homeostasis. Curr Opin Pharmacol. 2004;4:215–220
  14. Wimalawansa SJ. Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, pathophysiology, and therapeutic potentials. Endocr Rev. 1996;17:533–585
  15. Barklin A, Larsson A, Vestergaard C, et al. Does brain death induce a pro-inflammatory response at the organ level in a porcine model?. Acta Anaesthesiol Scand. 2008;52:621–627
  16. Barklin A, Larsson A, Vestergaard C, et al. Insulin alters cytokine content in two pivotal organs after brain death: a porcine model. Acta Anaesthesiol Scand. 2008;52:628–634
  17. Wijdicks EF. The diagnosis of brain death. N Engl J Med. 2001;344:1215–1221
  18. Wittwer T, Franke UF, Fehrenbach A, et al. Donor pretreatment using the aerosolized prostacyclin analogue iloprost optimizes post-ischemic function of non-heart beating donor lungs. J Heart Lung Transplant. 2005;24:371–378
  19. Steinberg J, Halter J, Schiller H, et al. Chemically modified tetracycline prevents the development of septic shock and acute respiratory distress syndrome in a clinically applicable porcine model. Shock. 2005;24:348–356
  20. Peterson BT, Griffith DE, Tate RW, Clancy SJ. Single-cycle bronchoalveolar lavage to determine solute concentrations in epithelial lining fluid. Am Rev Respir Dis. 1993;147:1216–1222
  21. Theodorsson-Norheim E, Hemsen A, Lundberg JM. Radioimmunoassay for neuropeptide Y (NPY): chromatographic characterization of immunoreactivity in plasma and tissue extracts. Scand J Clin Lab Invest. 1985;45:355–365
  22. Brodin E, Lindefors N, Dalsgaard CJ, Theodorsson-Norheim E, Rosell S. Tachykinin multiplicity in rat central nervous system as studied using antisera raised against substance P and neurokinin A. Regul Pept. 1986;13:253–272
  23. Theodorsson-Norheim E, Hemsen A, Brodin E, Lundberg JM. Sample handling techniques when analyzing regulatory peptides. Life Sci. 1987;41:845–848
  24. Ryan T, Petrovic O, Dillon JC, Feigenbaum H, Conley MJ, Armstrong WF. An echocardiographic index for separation of right ventricular volume and pressure overload. J Am Coll Cardiol. 1985;5:918–927
  25. Lyons JM, Pearl JM, McLean KM, et al. Glucocorticoid administration reduces cardiac dysfunction after brain death in pigs. J Heart Lung Transplant. 2005;24:2249–2254
  26. Szabo G. Physiologic changes after brain death. J Heart Lung Transplant. 2004;23(9 suppl):S223–S226
  27. Roos J, Kelly RB. Preassembly and transport of nerve terminals: a new concept of axonal transport. Nat Neurosci. 2000;3:415–417
  28. Hokfelt T, Bartfai T, Bloom F. Neuropeptides: opportunities for drug discovery. Lancet Neurol. 2003;2:463–472
  29. Nan YS, Feng GG, Hotta Y, et al. Neuropeptide Y enhances permeability across a rat aortic endothelial cell monolayer. Am J Physiol Heart Circ Physiol. 2004;286:H1027–H1033

 Funding: Aarhus University Research Foundation, The Danish Research Council, Holger og Ruth Hesses Mindefond.

PII: S1053-2498(09)00230-7

doi: 10.1016/j.healun.2009.04.008

The Journal of Heart and Lung Transplantation
Volume 28, Issue 7 , Pages 725-732 , July 2009

Article Tools

* Image Usage & Resolution