The Journal of Heart and Lung Transplantation
Volume 28, Issue 7 , Pages 746-748 , July 2009

Regression of Cardiac Amyloid After Autologous Stem-cell Transplantation

  • John E.A. Blair, MD

      Affiliations

    • Feinberg School of Medicine, Northwestern University, Chicago, Illinois
    • ,
  • Sanford M. Zeigler, BA

      Affiliations

    • Medical University of South Carolina, Charleston, South Carolina
    • ,
  • Jayesh Mehta, MD

      Affiliations

    • Feinberg School of Medicine, Northwestern University, Chicago, Illinois
    • ,
  • Seema Singhal, MD

      Affiliations

    • Feinberg School of Medicine, Northwestern University, Chicago, Illinois
    • ,
  • William Cotts, MD

      Affiliations

    • Feinberg School of Medicine, Northwestern University, Chicago, Illinois
    • Corresponding Author InformationReprint requests: William Cotts, MD, Bluhm Cardiovascular Institute, Feinberg School of Medicine, Northwestern University, 201 East Huron Street, Galter 11-120, Chicago, IL 60611. Telephone: 312-695-0008. Fax: 312-695-0005

Received 21 August 2008 ,Revised 1 November 2008 ,Accepted 14 November 2008.

References 

  1. Falk RH. Diagnosis and management of the cardiac amyloidoses. Circulation. 2005;112:2047–2060
  2. Kristen AV, Perz JB, Schonland SO, et al. Rapid progression of left ventricular wall thickness predicts mortality in cardiac light-chain amyloidosis. J Heart Lung Transplant. 2007;26:1313–1319
  3. Vesole DH, Perez WS, Akasheh M, et al. High-dose therapy and autologous hematopoietic stem cell transplantation for patients with primary systemic amyloidosis: a Center for International Blood and Marrow Transplant Research Study. Mayo Clin Proc. 2006;81:880–888
  4. Murtagh B, Hammill SC, Gertz MA, et al. Electrocardiographic findings in primary systemic amyloidosis and biopsy-proven cardiac involvement. Am J Cardiol. 2005;95:535–537
  5. Comenzo RL. Managing systemic light-chain amyloidosis. J Nat Compr Cancer Netw. 2007;5:179–187
  6. Selvanayagam JB, Hawkins PN, Paul B, et al. Evaluation and management of the cardiac amyloidosis. J Am Coll Cardiol. 2007;50:2101–2110
  7. Rahman JE, Helou EF, Gelzer-Bell R, et al. Noninvasive diagnosis of biopsy-proven cardiac amyloidosis. J Am Coll Cardiol. 2004;43:410–415
  8. Dispenzieri A, Kyle RA, Lacy MQ, et al. Superior survival in primary systemic amyloidosis patients undergoing peripheral blood stem cell transplantation: a case–control study. Blood. 2004;103:3960–3963
  9. Comenzo RL, Vosburgh E, Falk RH, et al. Dose-intensive melphalan with blood stem-cell support for the treatment of AL (amyloid light-chain) amyloidosis: survival and responses in 25 patients. Blood. 1998;91:3662–3670
  10. Saba N, Sutton D, Ross H, et al. High treatment-related mortality in cardiac amyloid patients undergoing autologous stem cell transplant. Bone Marrow Transplant. 1999;24:853–855
  11. Sanchorawala V, Wright DG, Seldin DC, et al. An overview of the use of high-dose melphalan with autologous stem cell transplantation for the treatment of AL amyloidosis. Bone Marrow Transplant. 2001;28:637–642
  12. Perz JB, Kristen AV, Rahemtulla A, et al. Long-term survival in a patient with AL amyloidosis after cardiac transplantation followed by autologous stem cell transplantation. Clin Res Cardiol. 2006;95:671–674
  13. Lacy MQ, Dispenzieri A, Hayman SR, et al. Autologous stem cell transplant after heart transplant for light chain (Al) amyloid cardiomyopathy. J Heart Lung Transplant. 2008;27:823–829
  14. Saito M, Hayashi T, Nojima M, et al. Long-term survival after autologous peripheral blood stem cell transplantation in a patient with primary AL amyloidosis complicating congestive heart failure [in Japanese]. Rinsho Ketsueki. 2007;48:1478–1483
  15. Moreau P, Milpied N, de Faucal P, et al. High-dose melphalan and autologous bone marrow transplantation for systemic AL amyloidosis with cardiac involvement. Blood. 1996;87:3063–3064
  16. Yagi S, Akaike M, Ozaki S, et al. Improvement of cardiac diastolic function and prognosis after autologous peripheral blood stem cell transplantation in AL cardiac amyloidosis. Intern Med. 2007;46:1705–1710
  17. Oh IY, Kim HK, Kim YJ, et al. An intriguing case of primary amyloidosis with cardiac involvement: symptomatic and echocardiographic improvement with thalidomide treatment. Int J Cardiol. 2006;113:141–143
  18. Mehta J. Amyloidosis: Graviores morbos, Asperis remedii. Blood. 2007;110:3490–3491

PII: S1053-2498(09)00161-2

doi: 10.1016/j.healun.2008.11.918

The Journal of Heart and Lung Transplantation
Volume 28, Issue 7 , Pages 746-748 , July 2009

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