The Journal of Heart and Lung Transplantation
Volume 27, Issue 7 , Pages 710-717 , July 2008

Location and Density of α- and β-Adrenoreceptor Sub-types in Myocardium After Mechanical Left Ventricular Unloading

  • Pippa M. Schnee, BA

      Affiliations

    • Department of Cardiovascular Surgical Research and Texas Heart Institute, St Luke's Episcopal Hospital, Houston, Texas
    • Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, Texas
    • ,
  • Naeema Shah, MS

      Affiliations

    • Department of Cardiovascular Surgical Research and Texas Heart Institute, St Luke's Episcopal Hospital, Houston, Texas
    • ,
  • Marianne Bergheim, BA

      Affiliations

    • Department of Cardiovascular Surgical Research and Texas Heart Institute, St Luke's Episcopal Hospital, Houston, Texas
    • ,
  • Brian J. Poindexter, MS

      Affiliations

    • Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, Texas
    • ,
  • L. Maximilian Buja, MD

      Affiliations

    • Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, Texas
    • Department of Cardiovascular Pathology, Texas Heart Institute, St Luke's Episcopal Hospital, Houston, Texas
    • ,
  • Courtney Gemmato, MS

      Affiliations

    • Department of Cardiovascular Surgical Research and Texas Heart Institute, St Luke's Episcopal Hospital, Houston, Texas
    • ,
  • Branislav Radovancevic, MD

      Affiliations

    • Department of Cardiovascular Surgical Research and Texas Heart Institute, St Luke's Episcopal Hospital, Houston, Texas
    • ,
  • George V. Letsou, MD

      Affiliations

    • Department of Surgery, University of Texas Medical School at Houston, Houston, Texas.
    • ,
  • O. Howard Frazier, MD

      Affiliations

    • Department of Cardiovascular Surgical Research and Texas Heart Institute, St Luke's Episcopal Hospital, Houston, Texas
    • ,
  • Roger J. Bick, FAHA, MIBiol

      Affiliations

    • Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, Texas
    • Corresponding Author InformationReprint requests: Roger J. Bick, FAHA, Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, MSB 2.288, 6431 Fannin Street, Houston, TX 77030. Telephone: 713-500-5406. Fax: 713-500-0730.

Received 10 April 2007 ,Revised 13 February 2008 ,Accepted 27 March 2008.

References 

  1. Brodde OE, Michel MC, Wang XL, Zerkowski HR. Chronic beta-adrenoceptor antagonist treatment modulates human cardiac and vascular beta-adrenoceptor density in a subtype-selective fashion. J Hypertens. 1988;6(suppl):S497–S500
  2. Summers RJ, Molnaar P, Russell F, et al. Coexistence and localization of beta 1- and beta 2-adrenoceptors in the human heart. Eur Heart J. 1989;10(suppl B):11–21
  3. Bohm M, Flesch M, Schnabel P. Beta-adrenergic signal transduction in the failing and hypertrophied myocardium. J Mol Med. 1997;75:842–848
  4. Brodde OE, Zerkowski HR, Doetsch N, et al. Myocardial beta-adrenoceptor changes in heart failure: concomitant reduction in beta 1- and beta 2-adrenoceptor function related to the degree of heart failure in patients with mitral valve disease. J Am Coll Cardiol. 1989;14:323–331
  5. Chavey WE. The importance of beta blockers in the treatment of heart failure. Am Fam Phys. 2000;62:2453–2462
  6. Dobre D, van Jaarsveld CH, deJongste MJ, Haaijer Ruskamp FM, Ranchor AV. The effect of beta-blocker therapy on quality of life in heart failure patients: a systematic review and meta-analysis. Pharmacoepidemiol Drug Saf. 2007;16:152–159
  7. Goldstein S. Beta blocker therapy in African American patients with heart failure. Heart Fail Rev. 2004;9:161–167
  8. Young R, Worthley LI. Current concepts in the management of heart failure. Crit Care Resusc. 2004;6:31–53
  9. Frigerio M, Roubina E. Drugs for left ventricular remodeling in heart failure. Am J Cardiol. 2005;96:10L-8
  10. Radovancevic B, Vrtovec B, Frazier OH. Left ventricular assist devices: an alternative to medical therapy for end-stage heart failure. Curr Opin Cardiol. 2003;18:210–214
  11. Bick RJ, Grigore AM, Poindexter BJ, et al. Left ventricular unloading with an assist device results in receptor relocalization as well as increased beta-adrenergic receptor numbers: are these changes indications for outcome?. J Card Surg. 2005;20:332–336
  12. Grigore A, Poindexter B, Vaughn WK, et al. Alterations in alpha adrenoreceptor density and localization after mechanical left ventricular unloading with the Jarvik flowmaker left ventricular assist device. J Heart Lung Transplant. 2005;24:609–613
  13. Ferrari M, Kadipasaoglu KA, Croitoru M, et al. Evaluation of myocardial function in patients with end-stage heart failure during support with the Jarvik 2000 left ventricular assist device. J Heart Lung Transplant. 2005;24:226–228
  14. Hon JK, Yacoub MH. Bridge to recovery with the use of left ventricular assist device and clenbuterol. Ann Thorac Surg. 2003;75(suppl):S36–S41
  15. Siegenthaler MP, Frazier OH, Beyersdorf F, et al. Mechanical reliability of the Jarvik 2000 Heart. Ann Thorac Surg. 2006;81:1752–1758
  16. Birks EJ, Yacoub MH, Banner NR, Khaghani A. The role of bridge to transplantation: should LVAD patients be transplanted?. Curr Opin Cardiol. 2004;19:148–153
  17. Dandel M, Weng Y, Siniawski H, Potapov E, Lehmkuhl HB, Hetzer R. Long-term results in patients with idiopathic dilated cardiomyopathy after weaning from left ventricular assist devices. Circulation. 2005;112:I-37–I-45
  18. Frazier OH, Myers TJ, Westaby S, Gregoric ID. Use of the Jarvik 2000 left ventricular assist system as a bridge to heart transplantation or as destination therapy for patients with chronic heart failure. Ann Surg. 2003;237:631–636
  19. Ogletree-Hughes ML, Stull LB, Sweet WE, et al. Mechanical unloading restores beta-adrenergic responsiveness and reverses receptor downregulation in the failing human heart. Circulation. 2001;104:881–886
  20. DiPaola NR, Sweet WE, Stull LB, Francis GS, Schomisch Moravec C. Beta-adrenergic receptors and calcium cycling proteins in non-failing, hypertrophied and failing human hearts: transition from hypertrophy to failure. J Mol Cell Cardiol. 2001;33:1283–1295
  21. Shan K, Bick RJ, Poindexter BJ, et al. Altered adrenergic receptor density in myocardial hibernation in humans: a possible mechanism of depressed myocardial function. Circulation. 2000;102:2599–2606
  22. Feldman AM. From clinical trials to clinical practice: what we know and do not know about beta-blockers and the heart. J Card Fail. 2000;6:34–39
  23. Huang Y, Wright CD, Merkwan CL, et al. An alpha1A-adrenergic-extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes. Circulation. 2007;115:763–772
  24. Baker JG, Hall IP, Hill SJ. Agonist actions of “beta-blockers” provide evidence for two agonist activation sites or conformations of the human beta1-adrenoceptor. Mol Pharmacol. 2003;63:1312–1321
  25. Bundkirchen A, Brixius K, Bolck B, Nguyen Q, Schwinger RH. Beta 1-adrenoceptor selectivity of nebivolol and bisoprolol (A comparison of [3H]CGP 12.177 and [125I]iodocyanopindolol binding studies). Eur J Pharmacol. 2003;460:19–26
  26. Bavendiek U, Brixius K, Frank K, et al. Altered inotropism in the failing human myocardium. Basic Res Cardiol. 1996;91(suppl 2):9–16
  27. Kohi M, Yang HT, Endoh M. Myocardial alpha 1A-adrenoceptor subtypes in rabbit: differentiation by a selective antagonist, HV723. Eur J Pharmacol. 1993;250:95–101
  28. Kurokawa H, Murray PA, Damron DS. Propofol attenuates beta-adrenoreceptor-mediated signal transduction via a protein kinase C-dependent pathway in cardiomyocytes. Anesthesiology. 2002;96:688–698
  29. Gregorini L. Adrenergic receptors: the key therapeutic target. J Clin Basic Cardiol. 2004;7:30–32
  30. Zhou YY, Song LS, Lakatta EG, Xiao RP, Cheng H. Constitutive beta2-adrenergic signalling enhances sarcoplasmic reticulum Ca2+ cycling to augment contraction in mouse heart. J Physiol. 1999;521:351–361
  31. Tseng YT, Kopel R, Stabila JP, et al. Beta-adrenergic receptors (betaAR) regulate cardiomyocyte proliferation during early postnatal life. FASEB J. 2001;15:1921–1926
  32. Varma DR, Deng XF. Cardiovascular alpha1-adrenoceptor subtypes: functions and signaling. Can J Physiol Pharmacol. 2000;78:267–292
  33. Knowlton KU, Michel MC, Itani M, et al. The alpha 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy. J Biol Chem. 1993;268:15374–15380
  34. Yun J, Zuscik MJ, Gonzalez-Cabrera P, et al. Gene expression profiling of alpha(1b)-adrenergic receptor-induced cardiac hypertrophy by oligonucleotide arrays. Cardiovasc Res. 2003;57:443–455
  35. Hopkins SR, Bogaard HJ, Niizeki K, Yamaya Y, Ziegler MG, Wagner PD. Beta-adrenergic or parasympathetic inhibition, heart rate and cardiac output during normoxic and acute hypoxic exercise in humans. J Physiol. 2003;550:605–616
  36. Poindexter BJ, Smith JR, Buja LM, Bick RJ. Calcium signaling mechanisms in dedifferentiated cardiac myocytes: comparison with neonatal and adult cardiomyocytes. Cell Calcium. 2001;30:373–382
  37. Koshimizu TA, Tanoue A, Hirasawa A, Yamauchi J, Tsujimoto G. Recent advances in alpha1-adrenoceptor pharmacology. Pharmacol Ther. 2003;98:235–244
  38. Rorabaugh BR, Gaivin RJ, Papay RS, et al. Both alpha(1A)- and alpha(1B)-adrenergic receptors crosstalk to down regulate beta(1)-ARs in mouse heart: coupling to differential PTX-sensitive pathways. J Mol Cell Cardiol. 2005;39:777–784
  39. Badino P, Odore R, Re G. Are so many adrenergic receptor subtypes really present in domestic animal tissues? (A pharmacological perspective). Vet J. 2005;170:163–174
  40. Rashidi A, Rahman M, Wright JT. Which drug should be used to treat patients with uncomplicated essential hypertension?. Curr Opin Nephrol Hypertens. 2006;15:303–308
  41. Schnee PM, Shah N, Bergheim M, et al. Reversal of myocyte hypertrophy by ventricular unloading: cardiac improvement without adrenergic receptor up-regulation and relocalization. Med Gen Med. 2006;8:45
  42. Wei JW, Sulakhe PV. Identity of [3H]dihydroalprenolol binding sites and beta-2 adrenergic receptors coupled with adenylate cyclase in guinea-pig skeletal muscle sarcolemma: general properties and structure–activity relationships. J Pharmacol Exp Ther. 1980;214:186–196
  43. Brixius K, Bloch W, Ziskoven C, et al. Beta3-adrenergic eNOS stimulation in left ventricular murine myocardium. Can J Physiol Pharmacol. 2006;84:1051–1060
  44. Bick RJ, Poindexter BJ, Buja LM, et al. Improved sarcoplasmic reticulum function after mechanical left ventricular unloading. Cardiovasc Pathobiol. 1997;2:159–166
  45. Bruckner BA, Stetson SJ, Perez-Verdia A, et al. Regression of fibrosis and hypertrophy in failing myocardium following mechanical circulatory support. J Heart Lung Transplant. 2001;20:457–464
  46. Xydas S, Rosen RS, Ng C, et al. Mechanical unloading leads to echocardiographic, electrocardiographic, neurohormonal, and histologic recovery. J Heart Lung Transplant. 2006;25:7–15

PII: S1053-2498(08)00277-5

doi: 10.1016/j.healun.2008.03.015

The Journal of Heart and Lung Transplantation
Volume 27, Issue 7 , Pages 710-717 , July 2008

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