The Journal of Heart and Lung Transplantation
Volume 27, Issue 5 , Pages 528-535 , May 2008

Infections in Lung Allograft Recipients: Ganciclovir Era

  • Vincent G. Valentine, MD, FCCP, FACP

      Affiliations

    • Multi-Organ Transplant Center, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas
    • Corresponding Author InformationReprint requests: Vincent Valentine, MD, FCCP, FACP, Multi-Organ Transplant Center, Department of Internal Medicine, University of Texas Medical Branch, 4.140 John McCullough Building, 301 University Boulevard, Galveston, TX 77555-0772. Telephone: 409-772-3115. Fax: 409-747-1901.
    • ,
  • Ryan W. Bonvillain, BS

      Affiliations

    • Departments of Medicine and Genetics, Louisiana State University Health Sciences Center, New Orleans, Louisiana
    • ,
  • Meera R. Gupta, MD

      Affiliations

    • Multi-Organ Transplant Center, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas
    • ,
  • Gisele A. Lombard, RN, CCTC

      Affiliations

    • Multi-Organ Transplant Center, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas
    • ,
  • Stephanie G. LaPlace, RNC, CCTC

      Affiliations

    • Lung Transplantation Program, Ochsner Medical Center, New Orleans, Louisiana
    • ,
  • Gundeep S. Dhillon, MD

      Affiliations

    • Lung Transplantation Program, Stanford University School of Medicine, Stanford, California.
    • ,
  • Guoshun Wang, DVM, PhD

      Affiliations

    • Departments of Medicine and Genetics, Louisiana State University Health Sciences Center, New Orleans, Louisiana

Received 4 May 2007 ,Revised 17 December 2007 ,Accepted 17 December 2007.

References 

  1. Brooks RG, Hofflin JM, Jamieson SW, Stinson EB, Remington JS. Infectious complications in heart-lung transplant recipients. Am J Med. 1985;79:412–422
  2. Penketh AR, Higenbottam TW, Hutter J, Coutts C, Stewart S, Wallwork J. Clinical experience in the management of pulmonary opportunist infection and rejection in recipients of heart-lung transplants. Thorax. 1988;43:762–769
  3. Horvath J, Dummer S, Loyd J, et al. Infection in the transplanted and native lung after single lung transplantation. Chest. 1993;104:681–685
  4. Nicod LP. Mechanisms of airway obliteration after lung transplantation. Proc Am Thorac Soc. 2006;3:444–449
  5. Hertz MI, Henki CA, Nakhleh RE, et al. Obliterative bronchiolitis after lung transplantation: a fibroproliferative disorder associated with platelet-derived growth factor. Proc Natl Acad Sci. 1992;89:10385–10389
  6. Boehler A, Estenne M. Post-transplant bronchiolitis obliterans. Eur Respir J. 2003;22:1007–1018
  7. Heyman L, Goddard M, McNiel K, Atkinson C, Sharples LD, Wallwork J. Is obliterative bronchiolitis in lung transplantation associated with microvascular damage to small airways?. Ann Thorac Surg. 2006;82:1212–1218
  8. Paradis IL, Williams P. Infection after lung transplantation. Semin Resp Infect. 1993;8:207–215
  9. Sole A, Morant P, Salavert M, et al. Aspergillus infections in lung transplant recipients: risk factors and outcome. Clin Microbiol Infect. 2005;11:359–365
  10. Mattner F, Chaberny IF, Weissbrodt H, et al. Surveillance of invasive mold infections in lung transplant recipients: effect of antimycotic prophylaxis with itraconazole and voriconazole. Mycoses. 2005;48(suppl 1):51–55
  11. Singhal P, Usuda K, Mehta AC. Post-lung transplantation Aspergillus niger infection. J Heart Lung Transplant. 2005;24:1446–1447
  12. Raviv Y, Kramer MR, Amital A, Rubinovitch B, Bishara J, Shitrit D. Outbreak of aspergillosis infections among lung transplant recipients. Eur Soc Organ Transpl. 2007;20:135–140
  13. Westney GE, Steven K, de Hoyos A, Chapparro C, Winton T, Maurer JR. Aspergillus infection in single and double lung transplant recipients. Transplantation. 1996;61:915–919
  14. Dummer JS, Lazariashvilli N, Barnes J, Ninan M, Milstone AP. A survey of anti-fungal management in lung transplantation. J Heart Lung Transplant. 2004;23:1376–1381
  15. Monforte V, Roman A, Gavalda J, Bravo C, Gispert P, Pahissa A, et al. Preemptive therapy with intravenous ganciclovir for the prevention of cytomegalovirus disease in lung transplant recipients. Transplant Proc. 2005;37:4039–4042
  16. Shlobin OA, West EE, Lechtzin N, et al. Persistent cytomegalovirus-specific memory responses in the lung allograft and blood following primary infection in lung transplant recipients. J Immunol. 2006;176:2625–2634
  17. Burton CM, Kristensen P, Lutzhoft R, et al. Cytomegalovirus infection in lung transplant recipients: the role of prophylaxis and recipient donor serotype matching. Scand J Infect Dis. 2006;38:281–289
  18. Ruttmann E, Geltner C, Bucher B, et al. Combined CMV prophylaxis improves outcome and reduces the risk for bronchiolitis obliterans syndrome (BOS) after lung transplantation. Transplantation. 2006;81:1415–1420
  19. Perreas KG, McNeil K, Charman S, Sharples LD, Wreghitt T, Wallwork J. Extended ganciclovir prophylaxis in lung transplantation. J Heart Lung Transplant. 2005;24:583–587
  20. Orens JB, Estenne M, Arcasoy S, et al. International guidelines for the selection of lung transplant candidates: 2006 update–a consensus report from the Pulmonary Scientific Council of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2006;25:745–755
  21. Frost AE. Donor criteria and evaluation. Clin Chest Med. 1997;18:231–237
  22. Struber M, Ehlers KA, Nilsson FN, Miller VM, McGregor CG, Haverich A. Effects of lung preservation with Euro-Collins and University of Wisconsin solutions on endothelium-dependent relaxation. Ann Thorac Surg. 1997;63:1428–1435
  23. Knower MT, Labella-Walker K, McFadden PM, Kantrow SP, Valentine VG. Clarithromycin for safe and cost-effective reduction of cyclosporine doses in lung allograft recipients. South Med J. 2000;93:1087–1092
  24. Valentine VG, McFadden PM, Ochsner JL. Advances in lung transplantation. Ochsner J. 1999;1:12–18
  25. Valentine VG, Taylor DE, Dhillon GS, et al. Success of lung transplantation without surveillance bronchoscopy. J Heart Lung Transplant. 2002;21:319–326
  26. Yousem SA, Berry GJ, Cagle PT, et al. Revision of the 1990 working formulation for the classification of pulmonary allograft rejection: Lung Rejection Study Group. J Heart Lung Transplant. 1996;15:1–15
  27. Cooper JD, Billingham ME, Egan T, et al. A working formulation for the standardization of nomenclature and for clinical staging of chronic dysfunction in lung allografts (International Society for Heart and Lung Transplantation). J Heart Lung Transplant. 1993;12:713–716
  28. Chen F, Bando T, Hanaoka N, Fukuse T, Hasegawa S, Wada H. Early onset of ganciclovir-resistent cytomegalovirus infection in a lung transplant recipient. Jpn J Thorac Cardiovasc Surg. 2005;53:562–564
  29. Kramer MR, Marshall SE, Starnes VA, Gamberg P, Amitai Z, Theodore J. Infectious complications in heart-lung transplantation. Arch Intern Med. 1993;153:2010–2016
  30. Speich R, van der Bij W. Epidemiology and management of infections after lung transplantation. Clin Infect Dis. 2001;33:S58–S65

PII: S1053-2498(08)00068-5

doi: 10.1016/j.healun.2007.12.013

The Journal of Heart and Lung Transplantation
Volume 27, Issue 5 , Pages 528-535 , May 2008

Article Tools

* Image Usage & Resolution