The Journal of Heart and Lung Transplantation
Volume 27, Issue 5 , Pages 564-567 , May 2008

Non-acidic Supraesophageal Reflux Associated With Diffuse Alveolar Damage and Allograft Dysfunction After Lung Transplantation: A Case Report

  • Kevin D. Halsey, MD

      Affiliations

    • Department of Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin
    • ,
  • Arnold Wald, MD

      Affiliations

    • Section of Gastroenterology and Hepatology, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin
    • ,
  • Keith C. Meyer, MD

      Affiliations

    • Section of Pulmonology, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin
    • ,
  • Jose R. Torrealba, MD

      Affiliations

    • Department of Pathology, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin.
    • ,
  • Eric A. Gaumnitz, MD

      Affiliations

    • Section of Gastroenterology and Hepatology, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin
    • Corresponding Author InformationReprint requests: Eric A. Gaumnitz, University of Wisconsin, School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53705. Telephone: 608-217-4193. Fax: -608-265-8143.

Received 29 May 2007 ,Revised 8 November 2007 ,Accepted 13 January 2008.

References 

  1. Whelan TPM, Hertz IH. Allograft rejection after lung transplantation. Clin Chest Med. 2005;26:599–612
  2. Ovidio FD, Singer LG, Hadjiliadis D, et al. Prevalence of gastroesophageal reflux in end-stage lung disease candidates for lung transplant. Ann Thorac Surg. 2005;80:1254–1261
  3. Davis RD, Lau CL, Eubank S, et al. Improved lung allograft function after fundoplication in patients with gastroesophageal reflux disease undergoing lung transplantation. J Thorac Cardiovasc Surg. 2003;125:533–542
  4. Young LR, Hadjiliadis D, Davis RD, Palmer SM. Lung transplantation exacerbates gastroesophageal reflux disease. Chest. 2003;124:1689–1693
  5. Hadjiliadis D, Davis RD, Messier RH, Lau CL, Eubanks SS, Palmer SM. Gasroesophageal reflux disease in lung transplant recipients. Clin Transplant. 2003;17:363–368
  6. Raghu G, Freudenberger TD, Yang S, et al. High prevalence of abnormal acid gastro-oesophageal reflux in idiopathic pulmonary fibrosis. Eur Respir J. 2006;27:136–142
  7. Vela MF, Camacho-Lobato L, Srinivasan R, Tutuian R, Katz PO, Castell DO. Simultaneous intraesophageal impedance and ph measurement of acid and nonacid gastroesophageal reflux: effect of omeprazole. Gastroenterology. 2001;120:1599–1606
  8. Hosenpud JD, Bennet LE, Keck BM, Boucek MM, Novick RJ. The Registry of the International Society of Heart and Lung Transplantation: eighteenth official report -2001. J Heart Lung Transplant. 2001;20:805–815
  9. Trulock EP, Edwards LB, Taylor DO, et al. The registry of the International Society for Heart and Lung Transplantation: twentieth official adult lung and heart-lung transplant report-2003. J Heart Lung Transplant. 2003;22:625–635
  10. Fisher AJ, Wardle J, Dark JH, Corris PA. Non-immune acute graft injury after lung transplantation and the risk of subsequent bronchiolitis obliterans syndrome (BOS). J Heart Lung Transplant. 2002;21:1206–1212
  11. Bittmann I, Muller C, Behr J, Groetzner J, Frey L, Lohrs U. Fas/FasL and perforin/granzyme pathway in acute rejection and diffuse alveolar damage after allogeneic lung transplantation-a human biopsy study. Virchows Arch. 2004;445:375–381
  12. Burton CM, Iversen M, Milman N, et al. Outcome of lung transplanted patients with primary graft dysfunction. Eur J Cardiothorac Surg. 2007;31:75–82
  13. Savici D, Katzenstein AL. Diffuse alveolar damage and recurrent respiratory failure: report of 6 cases. Hum Pathol. 2001;32:1398–1402
  14. Reid KR, McKenzie FN, Menkis AH, et al. Importance of chronic aspiration in recipients of heart-lung transplants. Lancet. 1990;336:206–208
  15. Palmer SM, Miralles AP, Howell DN, Brazer SR, Tapson VF, Davis RD. Gastroesophageal reflux as a reversible cause of allograft dysfunction after lung transplantation. Chest. 2000;118:1214–1217
  16. Cantu E, Appel JZ, Hartwig MG, et al. Early fundoplication prevents chronic allograft dysfunction in patients with gastroesophageal reflux disease. Ann Thorac Surg. 2004;78:1142–1151
  17. Mainie I, Tutuian R, Shay S, et al. Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy (A multicentre study using combined ambulatory impedance-pH monitoring). Gut. 2006;55:1398–1402
  18. Mainie I, Tutuian R, Agrawal A, et al. Fundoplication eliminates chronic cough due to non-acid reflux identified by impedance pH monitoring. Thorax. 2005;60:521–523
  19. D'Ovidio F, Mura M, Tsang M, et al. Bile acid aspiration and the development of bronchiolitis obliterans after lung transplantation. J Thorac Cardiovasc Surg; 129:1144–51.

PII: S1053-2498(08)00048-X

doi: 10.1016/j.healun.2008.01.020

The Journal of Heart and Lung Transplantation
Volume 27, Issue 5 , Pages 564-567 , May 2008

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