Non-acidic Supraesophageal Reflux Associated With Diffuse Alveolar Damage and Allograft Dysfunction After Lung Transplantation: A Case Report

Received 29 May 2007; received in revised form 8 November 2007; accepted 13 January 2008.

Advances in lung transplantation have improved 1-year survival rates, but allograft dysfunction continues to be a significant cause of post-transplant death. Diffuse alveolar damage is an early indication of allograft dysfunction and has been linked to gastroesophageal reflux. We report a case of diffuse alveolar damage–associated allograft dysfunction in a patient found to have significant non-acid gastroesophageal reflux.

a Department of Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin

b Section of Gastroenterology and Hepatology, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin

c Section of Pulmonology, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin

d Department of Pathology, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin.

Reprint requests: Eric A. Gaumnitz, University of Wisconsin, School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53705. Telephone: 608-217-4193. Fax: -608-265-8143.

PII: S1053-2498(08)00048-X

doi:10.1016/j.healun.2008.01.020

18 of 22