The Journal of Heart and Lung Transplantation
Volume 27, Issue 3 , Pages 325-328, March 2008

Performance of Limited Sampling Strategies for Predicting Mycophenolic Acid Area Under the Curve in Thoracic Transplant Recipients

  • Lillian S.L. Ting, MSc

      Affiliations

    • Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • Nilufar Partovi, PharmD, FCSHP

      Affiliations

    • Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    • Department of Pharmacy, Vancouver General Hospital, Vancouver, British Columbia, Canada
    • ,
  • Robert D. Levy, MD, FRCPC

      Affiliations

    • Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    • Division of Respiratory Medicine, St. Paul’s Hospital and Vancouver General Hospital, Vancouver, British Columbia, Canada
    • The British Columbia Transplant Society, Vancouver, British Columbia, Canada
    • James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • Andrew P. Ignaszewski, MD, FRCPC

      Affiliations

    • Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    • The British Columbia Transplant Society, Vancouver, British Columbia, Canada
    • Heart Function Clinic, St Paul’s Hospital, Providence HealthCare, Vancouver, British Columbia, Canada
    • ,
  • Mary H.H. Ensom, PharmD, FASHP, FCCP, FCSHP, FCAHS

      Affiliations

    • Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    • Department of Pharmacy, Children’s and Women’s Health Centre of British Columbia, Vancouver, British Columbia, Canada.
    • Corresponding Author InformationReprint requests: Mary H. H. Ensom, PharmD, Faculty of Pharmaceutical Sciences, University of British Columbia, c/o Pharmacy Department (OB7), Children’s and Women’s Health Center, Vancouver, BC V6H 6N1, Canada. Telephone: 604-875-3735. Fax: 604-875-3735.

Background and Methods

Eight limited sampling strategies (LSSs) for estimating mycophenolic acid area under the concentration–time curve (4 developed from lung transplant recipients at our center, 4 developed for heart transplant recipients from other research groups) were evaluated in 27 heart or heart–kidney transplant patients.

Results

The LSSs from our lung transplant patients performed well when applied to the heart transplant population, with percent bias and percent precision within the acceptable limit of ±15%.

Conclusions

The LSSs developed at our center are robust enough to be applied to both lung and heart transplant populations. Application of LSSs from other research groups yielded less optimal results, reinforcing the need to re-establish or re-validate LSSs for each specific center.

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 Supported by the Canadian Institutes of Health Research (MOP #133946) and the Bong Pang Yee Endowment Fund, and a BC Medical Services Foundation Pre-Doctoral Fellowship (to L.S.L.T.), CIHR Canada Graduate Scholarships Doctoral Award (to L.S.L.T.) and the Michael Smith Foundation for Health Research Incentive Award (to L.S.L.T.). Analytical-grade mycophenolic acid was provided as a gift from Roche Palo Alto LLC.

PII: S1053-2498(07)01527-6

doi:10.1016/j.healun.2007.12.009

The Journal of Heart and Lung Transplantation
Volume 27, Issue 3 , Pages 325-328, March 2008

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