The Journal of Heart and Lung Transplantation
Volume 27, Issue 3 , Pages 302-309 , March 2008

Assessment and Characterization of Time-related Differences in Plaque Composition by Intravascular Ultrasound–derived Radiofrequency Analysis in Heart Transplant Recipients

  • Andreas König, MD

      Affiliations

    • Department of Medicine, Division of Cardiology, Medizinische Klinik und Poliklinik–Innenstadt, Munich, Germany
    • Corresponding Author InformationReprint requests: Andreas König, MD, Department of Medicine, Division of Cardiology, Medizinische Klinik und Poliklinik-Innenstadt, Ludwig-Maximilians-Universität, Ziemssenstrasse 1, 80336 Munich, Germany. Telephone: 0049-89-5160-7670. Fax: 0049-89-5160-2152.
    • ,
  • Eckehard Kilian, MD

      Affiliations

    • Department of Cardiac Surgery, Klinikum Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany
    • ,
  • Hae-Young Sohn, MD

      Affiliations

    • Department of Medicine, Division of Cardiology, Medizinische Klinik und Poliklinik–Innenstadt, Munich, Germany
    • ,
  • Johannes Rieber, MD

      Affiliations

    • Department of Medicine, Division of Cardiology, Medizinische Klinik und Poliklinik–Innenstadt, Munich, Germany
    • ,
  • Thomas Michael Schiele, MD

      Affiliations

    • Department of Medicine, Division of Cardiology, Medizinische Klinik und Poliklinik–Innenstadt, Munich, Germany
    • ,
  • Uwe Siebert, MD, MPH

      Affiliations

    • Department of Public Health, Medical Decision Making and Health Technology Assessment, University of Health Sciences, Medical Informatics and Technology, Hall, Austria
    • Institute for Technology Assessment and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
    • ,
  • Raffaella M. Gothe

      Affiliations

    • Department of Public Health, Medical Decision Making and Health Technology Assessment, University of Health Sciences, Medical Informatics and Technology, Hall, Austria
    • ,
  • Bruno Reichart, MD

      Affiliations

    • Department of Cardiac Surgery, Klinikum Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany
    • ,
  • Volker Klauss, MD

      Affiliations

    • Department of Medicine, Division of Cardiology, Medizinische Klinik und Poliklinik–Innenstadt, Munich, Germany

Received 21 September 2007 ,Revised 5 December 2007 ,Accepted 14 December 2007.

References 

  1. Hosenpud JD, Bennett LE, Keck BM, Boucek MM, Novick RJ. The registry of the International Society for Heart and Lung Transplantation: seventeenth official report—2000. J Heart Lung Transplant. 2000;19:909–931
  2. Klauss V, Mudra H, Überfuhr P, Theisen K. Intraindividual variability of cardiac allograft vasculopathy as assessed by intravascular ultrasound. Am J Cardiol. 1995;76:463–466
  3. Tuzcu M, DeFranco AC, Goormastic M, et al. Dichotomous pattern of coronary atherosclerosis 1 to 9 years after transplantation: insights from systematic intravascular ultrasound imaging. J Am Coll Cardiol. 1996;27:839–846
  4. Botas J, Pinto FJ, Chenzbraun A, et al. Influence of pre-existing donor coronary artery disease on the progression of transplant vasculopathy (An intravascular ultrasound study). Circulation. 1995;92:1126–1132
  5. Li H, Tanaka K, Anzai H, et al. Influence of pre-existing donor atherosclerosis on the development of cardiac allograft vasculopathy and outcomes in heart transplant recipients. J Am Coll Cardiol. 2006;47:2470–2476
  6. Kobashigawa JA, Tobis JM, Starling RC, et al. Multicenter intravascular ultrasound validation study among heart transplantation recipients (Outcomes after five years). J Am Coll Cardiol. 2005;45:1532–1537
  7. Tuzcu M, Kapadia SR, Sachar R, et al. Intravascular ultrasound evidence of angiographically silent progression in coronary atherosclerosis predicts long-term morbidity and mortality after cardiac transplantation. J Am Coll Cardiol. 2005;45:1538–1542
  8. Billingham ME. Histopathology of graft coronary disease. J Heart Lung Transplant. 1992;11:38–44
  9. Johnson DE, Gao SZ, Schroeder JS, DeCampli WM, Billingham ME. The spectrum of coronary artery pathologic findings in human cardiac allografts. J Heart Lung Transplant. 1989;8:349–359
  10. Lin H, Wilson JE, Kendall TJ, et al. Comparable proximal and distal severity of intimal thickening and size of epicardial coronary arteries in transplant arteriopathy of human cardiac allografts. J Heart Lung Transplant. 1994;13:824–833
  11. Nair A, Kuban BD, Tuzcu EM, et al. Coronary plaque classification with intravascular ultrasound radiofrequency data analysis. Circulation. 2002;106:2200–2206
  12. Moore MP, Spencer T, Salter DM, et al. Characterisation of coronary atherosclerotic morphology by spectral analysis of radiofrequency signal (In vitro intravascular ultrasound study with histological and radiological validation). Heart. 1998;79:459–467
  13. Nair A, Margolis MP, Kuban BD, Vince DG. Automated coronary plaque characterisation with intravascular ultrasound backscatter: ex vivo validation. EuroInterv. 2007;3:113–120
  14. Kapadia SR, Nissen SE, Ziada KM, et al. Development of transplantation vasculopathy and progression of donor-transmitted atherosclerosis (Comparison by serial intravascular ultrasound imaging). Circulation. 1998;98:2672–2678
  15. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20:1262–1275
  16. Rahmani M, Cruz RP, Granville DJ, McManus BM. Allograft vasculopathy versus atherosclerosis. Circ Res. 2006;99:801–815
  17. Rodriguez GA, Garcia-Garcia HM, McFadden EP, et al. In vivo ultrasound-derived thin cap fibroatheroma detection using ultrasound radiofrequency data analysis. J Am Coll Cardiol. 2005;46:2038–2042
  18. Virmani R, Burke AP, Kolodgie FD, Farb A. Pathology of the thin-cap fibroatheroma: a type of vulnerable plaque. J Interv Cardiol. 2003;16:267–272
  19. Konig A, Sohn HY, Rieber J, et al. Coronary plaque classification using intravascular ultrasound—radiofrequency analysis in a heart transplant patient with severe atherosclerosis. J Heart Lung Transplant. 2007;26:960–961
  20. Kaczmarek I, Ertl B, Schmauss D, et al. Preventing cardiac allograft vasculopathy: Long-term beneficial effects of mycophenolate mofetil. J Heart Lung Transplant. 2006;25:550–556

PII: S1053-2498(07)01521-5

doi: 10.1016/j.healun.2007.12.003

The Journal of Heart and Lung Transplantation
Volume 27, Issue 3 , Pages 302-309 , March 2008

Article Tools

* Image Usage & Resolution